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Biomedical subjects

S Saxena

Publications and source records attributed to S Saxena.

At least 361 records · Page 20Linked to original sources
PubMedDate not supplied

Changing trends in heroin abuse in India: an assessment based on treatment records.

The study of drug addicts who were treated in the drug-abuse facilities of the All India Institute of Medical Sciences during the period from 1981 to May 1984 indicates a steady increase in the number of heroin addicts who sought treatment in those facilities. The majority of heroin addicts were under 30 years of age (87.6 per cent), unmarried (67.6 per cent), had reached either high school or college (80.0 per cent) and reported having taken up to one gram per day (56.6 per cent) of the drug for one year or less (63.8 per cent). Heroin was mainly smoked (74.3 per cent) and in some cases inhaled, sniffed or injected. Up to 1981 there were no heroin addicts recorded in the treatment facilities. Other studies in India support this evidence. On the basis of the recency of heroin addiction in India, and its trend and development in other countries of the region, the authors predict a rapid increase in heroin addiction and in the manufacture of heroin in the country.

Adolescent↗
PubMedDate not supplied

Autoimmune hemolytic anemia with both cold and warm autoantibodies.

Of 144 patients with a positive direct antiglobulin test and having autoimmune hemolytic anemia (AIHA), 12 (8.3%) satisfied diagnostic criteria for both warm antibody AIHA and cold agglutinin syndrome. All 12 patients had IgG and C3d sensitizing their erythrocytes, and samples of their serum contained IgM cold autohemagglutinins optimally reactive at 4 degrees C, but with a high thermal amplitude to 37 degrees C, and IgG warm autoantibodies. All red blood cell eluates contained IgG warm autoantibodies. The 12 patients had severe hemolytic anemia that responded dramatically to corticosteroid therapy, with the mean hemoglobin level increasing from 6.3 to 12.9 g/dL. Five patients (42%) had systemic lupus erythematosus, one patient (8%) had a non-Hodgkin's lymphoma, and six patients (50%) had idiopathic AIHA; four patients (33%) had concomitant thrombocytopenia (Evans' syndrome). Nine patients (75%) were female. Four patients had unexpected alloantibodies potentially capable of in vivo hemolysis of transfused blood. Because of the severe hemolysis, the serologic findings, and the dramatic initial clinical response to corticosteroid therapy, these patients represent a distinct catagory of AIHA and should be given corticosteroid therapy quickly.

Adolescent↗
PubMedDate not supplied

The quality of life in successful live-related renal allograft recipients in India.

BACKGROUND: The high cost of maintenance of haemodialysis makes most patients in India and elsewhere opt for a renal transplant. The degree of rehabilitation can best be assessed by evaluating the quality of life in successful recipients. METHODS: We studied vocational rehabilitation, social relations, sexual and married life, psychological status and life satisfaction in 51 successful live-related renal allograft recipients using Schwab's depressive scale, Bigot's life satisfaction index and the Kamofsky physical scale. RESULTS: Eight-four per cent of our patients had returned to their original jobs. Ninety-eight per cent of patients had a Kamofsky scale of 90-100 and 81% were leading a normal married life. Ninety-four per cent of them led an active social life. CONCLUSION: Successful live-related renal transplantation is associated with a good quality of life and should be the treatment of choice for patients with end-stage renal disease.

Adolescent↗