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Biomedical subjects

S Sawada

Publications and source records attributed to S Sawada.

656 records · Page 37Linked to original sources
PubMedDate not supplied

Transcatheter oily chemoembolization with high doses of adriamycin in the treatment of large hepatocellular carcinoma (10 cm or more in diameter).

Five patients with large hepatoma (10 cm or more in diameter) underwent transcatheter oily chemoembolization with an emulsion of 100 mg of adriamycin with Lipiodol plus Gelfoam. Myelosuppression related to adriamycin was milder than that associated with bolus injection of the drug, because the drug was released from the emulsion slowly. Partial response was found in one patient, with no change in the others. The duration of survival ranged from four to 16 months (mean, 11.2 months). Response was satisfactory for large hepatoma.

Adult↗
PubMedDate not supplied

Local hyperthermia combined with radiotherapy, chemotherapy, or arterial chemoembolization.

Local hyperthermia combined with radiotherapy, chemotherapy, or arterial chemoembolization was performed in 31 patients with malignant tumors using an HTM 3000 heater. The response rate was 41.9%. Fifteen patients with superficial tumors had a high rate of response (60%). Response was particularly good (75%) when radiotherapy was also used. In contrast, the response rate was low (25%) in 16 patients with deep seated tumors. However, the criteria for assessment might not be appropriate. If improvement in symptoms and intratumorous changes were also considered, the therapy was judged to be valuable in 56.3% of the patients. No adverse reactions of concern developed except in some special cases. Hyperthermia with the HTM 3000 heater was safe.

Adult↗
PubMedDate not supplied

Biliary reconstruction by using a long stent.

The possibility of biliary reconstruction in a patient with advanced cholangiocarcinoma is discussed. The technique involves internal-internal drainage from both sides of the hepatic lobes using a stiff guidewire under ultrasound guidance.

Adenoma, Bile Duct↗
PubMedDate not supplied

Radiation and thermal characteristics of mouse lymphoma cells and their radiation-sensitive mutant.

Radiation and thermal characteristics of L5178Y cells and their radiation-sensitive mutant M10 cells were studied by the colony-forming method and the dye-exclusion method using eosin-Y. Although M10 cells were remarkably radiation-sensitive compared with L5178Y cells, it was difficult to cause interphase death of M10 after a large dose of irradiation. After heat treatments, L5178Y cells revealed more cell destruction and were stained well by eosin-Y, but it was relatively difficult to produce cell destruction of M10 cells, which showed poor staining by eosin-Y. When assayed by the colony-forming method, M10 cells were also heat-resistant compared to L5178Y. The dye-exclusion rate was closely correlated with cell survival after hyperthermia of L5178Y cells, suggesting that this is a simple method of detecting the thermosensitivity and thermotolerance of cancer cells. The difference in survival of L5178Y cells and M10 cells after combined treatment with gamma irradiation and hyperthermia was smaller than with gamma irradiation alone. It was also found that there was a relationship between radiation-induced interphase death and hyperthermia-induced interphase death, and that interphase death accounted for a major part of cell death caused by hyperthermia in mouse leukemia cells.

Animals↗
PubMedDate not supplied

Ectopic calcinosis possibly due to 1 alpha (OH) vitamin D3 in a patient with systemic lupus erythematosus.

A 30-year-old woman with systemic lupus erythematosus (SLE) developed ectopic calcinosis. She had been receiving prednisolone since 1980 with the addition of vitamin D3 in 1986. Despite this therapy, her renal function had gradually deteriorated. Right gonalgia was noted in September 1991. X-ray findings revealed calcinosis of the arteries of the femur, poplitea, cubitus, hands, and feet. Her finger pads and joint sacs were also involved. Calcinosis seen in SLE has only rarely been reported, and that observed in association with vitamin D intoxication or arteriosclerosis has a different distribution of calcium deposits. The use of vitamin D3 in our patient with renal disability may have induced calcinosis with a unique distribution.

Adult↗
PubMedDate not supplied

Restriction fragment length polymorphism (RFLP) analysis in the TNF genes of patients with systemic lupus erythematosus (SLE).

Although systemic lupus erythematosus (SLE) is known to be positively associated with certain major histocompatibility complex (MHC) class I and/or class II antigens, it is not clear whether the MHC genes are the predisposing genes of the disease rather than markers for other closely linked gene(s). Because of the involvement of tumor necrosis factor (TNF) in the inflammation process and localization of the TNF genes in the proximity of the HLA-B locus, we studied the restriction fragment length polymorphism (RFLP) of the TNF-alpha and -beta genes in 20 SLE patients and 23 normal individuals using restriction endonuclease NcoI. The frequency of a 5.5 kb NcoI fragment from SLE patients was significantly higher than that from normal controls. This result suggests that the polymorphic TNF genes may be involved in the pathogenesis of SLE.

Alleles↗
PubMedDate not supplied

Increased soluble CD23 molecules in serum/saliva and correlation with the stage of sialoectasis in patients with primary Sjögren's syndrome.

OBJECTIVE: We examined the soluble CD23 (sCD23) molecules in sera and saliva from patients with Sjögren's syndrome. METHODS: The determination of sCD23 and other soluble molecules were made by the enzyme-linked immunosorbent assay. RESULTS: The amounts of sCD23 in the sera/saliva were significantly increased in the patients compared to the controls and the levels were significantly correlated with sialoectasis. CONCLUSION: The findings suggest that increased sCD23 molecules in saliva from patients with Sjögren's syndrome may reflect active sialoectasis.

Adult↗