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S Sassi

Publications and source records attributed to S Sassi.

52 records · Page 3Linked to original sources
PubMed1987

Liver cytosolic protein-bound folates in phenobarbitone-treated rats.

The effect of acute phenobarbitone treatment on the distribution of endogenous bound folates in three specific cytosolic folate-binding proteins (FBP-C), has been studied in rat liver. The bound folate amount shows no difference between treated and control rats. As it is well known that FBP's preferentially bind longer-chain polyglutamates, the content of which is markedly lower in phenobarbitone-treated rat liver, it might be suggested that shorter chain folates also bind to FBP's in these animals.

Animals↗
PubMed1987

Protein bound folates in liver of castrated rats.

The effect of castration and testosterone treatment on the distribution of [3H] radioactive and endogenous bound folates in hepatic cytosolic folate binding proteins (FBP-C) has been studied in rats. The distribution of [3H] radioactive bound folates in these FBP's shows no significant difference in the three experimental group animals. On the contrary a significant decrease in the amount of endogenous bound folates is observed in castrated if compared with control rats, particularly marked for FBP-CI and FBP-CII bound folates. The testosterone treatment of castrated rats partially restores bound folate levels. The decrease of bound folates in castrated rats might be ascribable to a lower availability of longer-chain forms, almost the ones that bind to FBP's; however lower binding protein content and/or lower affinity for ligands cannot be excluded.

Animals↗
PubMedDate not supplied

Pteroylpolyglutamate pool modifications in rat liver after chronic administration of phenobarbitone and valproate.

Chronic intraperitoneal administration of low doses of phenobarbitone and valproate caused different alterations in hepatic percentage distribution of pteroylpolyglutamate derivatives without modification of total folate content. Phenobarbitone treatment caused a significant decrease of the percentage content of reduced unsubstituted and methylene-substituted derivatives, while valproate produced an increase of the percentage content of methenyl-, formyl- and formimino-substituted derivatives and a concomitant percent increase of hexaglutamates. The modified ratios of various pteroylpolyglutamates, both in phenobarbitone- and in valproate-treated animals, probably contribute to influencing the partitioning of the one-carbon pool through the various areas of one-carbon metabolism.

Animals↗
PubMedDate not supplied

Homocysteinemia, serum folate and vitamin B12 in very young patients with diabetes mellitus type 1.

BACKGROUND: Recently a link between hyperhomocysteinemia [HH(e)] and diabetic micro- and macrovascular complications has been reported. However, it is far from clear whether HH(e) is an epiphenomenon or a cause of angiopathic complications. OBJECTIVE: To try to clarify this question we studied adolescents and young diabetic patients without or with only initial complications. SUBJECTS: Plasma levels of basal homocysteinemia [H(e)], folate and vitamin B12 were measured in 76 young diabetic patients (age range 13.6-32.2 yr) and 70 normal volunteers matched for sex and age. In 68 diabetic patients and 53 controls we evaluated the levels of homocysteinemia 2 h after a methionine-loading test. METHODS: Total (free + protein bound) plasma H(e) level was measured by HPLC. RESULTS: Basal or post-load HH(e) occurred in 4.1% of diabetic patients and 12.4% of controls (frequencies not statistically different). In diabetic patients plasma homocysteine values were statistically lower than in controls, but this difference was present only in females. The females showed lower homocysteine values and higher folate levels than males only in the diabetic group. We did not find significant differences in H(e) levels between patients with early complications, late complications or without complications of any type. CONCLUSIONS: Considering very young diabetic patients, the risk of hyperhomocysteinemia does not appear to be greater than in normal controls. Furthermore, our data seem to demonstrate that HH(e) is not a preexisting condition in diabetic patients, even in those predisposed to early complications.

Adolescent↗
PubMedDate not supplied

[Benign tumors and pseudotumors of temporo-mandibular joint: radiologic aspects].

Benign tumors and tumor-like lesions that involve temporo mandibular joint are very rare. Those more frequent are osteochondroma, chondroma, osteoma, pigmented villonodular synovitis and synovial chondromatosis. The Authors report six cases of patients affected by these pathologies in which imaging, such as TC, MRI and/or ortopantomography have been useful to have a diagnosis.

Adult↗
PubMedDate not supplied

[Nifedipine and kidney tubular function].

Aim of the study was to evaluate the influence of nifedipine on the proximal tubular handling of sodium, as judged by variations in the fractional excretion of lithium, which is a simple and reliable indicator of sodium and water reabsorption at this site. Lithium clearance was determined in 17 in-hospital essential hypertensives who took 16 mmol of lithium per os at 10 p.m. The following morning, urine was collected from 7 to 11 a.m. to determine sodium, potassium, lithium and creatinine concentration. The same analyses were performed in a sample of venous blood drawn at midpoint of the urine collection (9 a.m.). The test took place in basal conditions and was repeated 48 hours later when the patients assumed nifedipine, 10 mg per os, at the beginning of the urine collection (7 a.m.). Compared to basal values, nifedipine increased urinary sodium excretion (mean basal: 33.65 +/- 19.44 mEq/4 h; after nifedipine: 46.99 +/- 19.22) with no change in the fractional excretion of lithium. We conclude that the acute natriuretic effect of this calcium antagonist does not depend on variations in proximal tubular handling of sodium.

Female↗
PubMedDate not supplied

[Uremic cholangitis].

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Cholangitis↗