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Biomedical subjects

S Sander

Publications and source records attributed to S Sander.

At least 91 records · Page 5Linked to original sources
PubMed1985

Neodymium:YAG laser irradiation of urinary bladder tumors. Follow-up study of 100 consecutively treated patients.

Advanced laser beam technology has made endoscopic destruction of urinary bladder tumors possible. The neodymium: YAG laser is more suited for this purpose than the other available laser systems because of the higher penetration power into biological tissue. Small superficial tumors are particularly suitable for this treatment, but it is also possible to deal with muscle invasive tumors. The treatment procedure is simple and well tolerated by the patients. Recurrence of tumor in the irradiated area can be avoided by precise irradiation. In spite of being a no-touch technique, however, laser does not appear to prevent the occurrence of new tumors in nonirradiated areas.

Adult↗
PubMed1985

[Not Available].

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Germany↗
PubMed1984

Laser in the treatment of localized prostatic carcinoma.

Laser treatment associated with transurethral resection of the prostate is a new and promising approach for curative treatment of stages T1 and T2 prostatic cancer. The neodymium-YAG laser beam can be conducted down a flexible quartz fiber cable, which permits its use through a cystoscope. The laser provides an area of tissue destruction to a depth of 4 to 6 mm. Followup in 16 patients revealed no serious complications and the functional results have been good. Currently, 15 patients have no sign of disease, while treatment failed in 1 with stage T3 cancer. The value of laser treatment is confined to the control of local disease.

Adenocarcinoma↗
PubMed1984

Urethral sphincteric insufficiency in postmenopausal females: treatment with phenylpropanolamine and estriol separately and in combination. A urodynamic and clinical evaluation.

A randomized open comparative cross-over trial was carried out in 20 postmenopausal women, mean age 69 years, suffering from urinary incontinence due to urethral sphincteric insufficiency. They were treated with phenylpropanolamine (PPA) 50 mg p.o. twice daily or estriol vaginal suppositories 1 mg daily separately and in combination for periods of 4 weeks. Urodynamic investigations were carried out before and after each period of treatment. Both PPA and estriol increased the maximal urethral closure pressure and the continence area significantly compared to the initial values, but combined treatment was substantially more effective. The functional urethral length increased significantly while on estriol. No significant change was registered in the bladder pressure or in the pressure transmission ratio. PPA was clinically more effective than estriol, but not sufficient to obtain complete continence. With combined treatment 8 patients became completely continent, 9 were considerably improved and only 1 patient remained unchanged. 2 patients dropped out of the study because of side effects. Combined treatment with PPA and estriol represents a recommendable treatment to postmenopausal women with urinary incontinence due to urethral sphincteric insufficiency.

Aged↗
PubMed1982

[Acute scrotum].

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Acute Disease↗
PubMed1982

Influence of in vivo diethylstilbosterol phosphate on some human blood lymphocyte sub-populations.

The effects of in vivo diethylstilbosterol phosphate (DES-P) on lymphoid cells were studied in six patients with adenocarcinoma of the prostate. The administration of 500 mg DES-P intravenously caused increased numbers of circulating granulocytes, monocytes, and non-T lymphocytes lasting for 24-48 hours. The natural killer activity, as measured in a three-hours 51Cr-release assay with K562 cells as targets, was transiently depressed four hours after drug injection. Parallel variations were found in the fraction of lymphocytes bearing receptors for the Fc part of IgG. In mixed lymphocyte culture (MLC) the responding capacity of the T cells and the stimulatory capacity of the non-T cells were unaffected. In vitro preincubation with DES-P overnight was not toxic to the lymphocytes. To be suppressive in MLC DES-P had to be added in concentrations one thousand times higher than those of hydrocortisone. It is concluded that a single dose of DES-P in vivo modulates the kinetics of recirculating lymphoid cells.

Aged↗
PubMed1982

Treatment of early localized breast cancer in elderly patients by Tamoxifen.

Twenty-seven early localized breast cancer cases in elderly patients, 21 stage I and six stage II, were treated with Tamoxifen only. In 15 cases there was complete radiological remission and in seven cases partial remission or growth arrest. Five cases did not respond to treatment. Tamoxifen seemed to be a useful alternative treatment for this group of patients. Possibly tumour mass and growth rate may affect the response to antioestrogen treatment.

Aged↗
PubMed1982

Orchiectomy combined with cyproterone acetate or prednisone in the treatment of advanced prostatic carcinoma. A randomized clinical and endocrine study.

Thirty-four previously untreated patients with advanced prostatic carcinoma, histologically graded as being of intermediate differentiation, were randomized in three groups. All patients were treated with primary orchiectomy, group I was observed without additional therapy, group II treated with oral administration of prednisone and group III treated with cyproterone acetate per os. The clinical results with the combination orchiectomy and prednisone was encouraging both when initial and secondary remissions were considered. Cyproterone acetate treatment induced a highly significant raise in plasma prolactin, a fact which may explain the less favourable clinical results in this group.

Adenocarcinoma↗
PubMed1982

Urinary incontinence in old age.

Urinary incontinence is a common problem in old age, particularly among geriatric patients. Previous studies have shown an incidence of about 10% among old people in the community and about 30% among patients in nursing homes. The treatment so far has mainly been by catheter a demeure or napkins. In 1979 a study among 100 incontinent nursing home patients in Oslo was undertaken with the special intention to obtain correct classification and optimal treatment of the incontinence. The history in these cases was often misleading. Urodynamic investigations were therefore performed to obtain objective assessment. It appeared that most of the patients suffered from several conditions in their lower urinary tract which could be responsible for the incontinence. The results of treatment were acceptable as 38% of the patients became continent, 30% were improved whereas only 30% remained unchanged. It is concluded that urodynamic investigations are necessary to obtain a correct and differentiated diagnosis. If this is done appropriate treatment can be given. A plea is therefore made for using simultaneous urethrocystometry as a routine investigation in elderly patients with urinary incontinence.

Aged↗
PubMed1982

Urodynamic studies before and after retropubic urethropexy for stress incontinence in females.

Twenty-nine women, with a mean age of 47 years, having stress incontinence were investigated urodynamically before and after retropubic urethropexy. No major changes of the urethral pressure profile could be demonstrated. However, good correlations were noted between the clinical results and the changes in transmission of increased abdominal pressure to the urethra. It is concluded that both the maximal urethral closure pressure and the pressure transmission ratio are important parameters in selecting patients with stress incontinence who will benefit from surgical treatment and those who will not.

Adult↗
PubMed1981

Sensory urgency in females: treatment with phenylpropanolamine.

34 females with sensory urge incontinence have been treated with phenylpropanolamine, 50 mg twice daily, and in some cases alternatively with placebo. Subjective effect of the treatment was reported in 22 of the 34 patients, in only three cases out of 15 was a similar good response achieved with placebo. Objectively we found no significant difference either in maximum urethral pressure or in functional urethral length after treatment. Maximal bladder volume was markedly increased in four cases. There were no cases with uninhibited bladder contractions, compliance before and after treatment was normal. The most conspicuous objective finding urodynamically was a stabilization of the condition described as "unstable urethra", where the urethral pressure variation repeatedly exceeded 15 cm H2O. This stabilization was observed in 11 out of 14 cases with this condition in whom the clinical effect was also reported as good.

Adolescent↗