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Biomedical subjects

S Sabin

Publications and source records attributed to S Sabin.

18 recordsLinked to original sources
PubMed1979

[Passive protection tests in the mouse with pertussis immunoglobulin (author's transl)].

A reproducible method for potency-testing of pertussis-sera and - immunoglobulines in a neutralisation test in the mouse is described. The tests were done on two human immunoglobulines, one crude immune serum from the rabbit, and two purified resp. concentrated rabbit immune sera, one of which - the US-Standard for Pertussis Sera - was used as the standard preparation for the potency evaluation. There is no correlation between the results of the neutralisation test and the agglutination titer among the different preparations. That means, the agglutination titer is not suitable for comparing the potency of pertussis sera resp. - immunoglobulines. It seems necessary to establish a uniforme method as well as a standard preparation for potency testing of pertussis sera and - immunoglobulines on the basis of the neutralisation test in the mouse - at least on the European level.

Agglutination Tests↗
PubMed1979

Potency testing of pertussis immunoglobulins, relationship between neutralisation test and agglutination test.

Neutralisation tests were done with pertussis immunoglobulins and immunosera in which mice were immunised by intraperitoneal injection and challenged 4 hours later by intracerebral injection. The results of the neutralisation tests were compared with those of the agglutination tests done with the same preparations. For 2 pertussis immunoglobulins a correlation was found between the results of both tests, but generally no correlation exists between the agglutinating activity and the protective value of the preparations. There is a more than 100-fold difference in their relationship. Therefore a neutralisation test should be used for potency testing of pertussis immunoglobulins.

Agglutination Tests↗
PubMed1978

Drug-induced lupus erythematosus with in vivo lupus erythematosus cells in pleural fluid.

Pleural involvement in drug-induced lupus erythematosus is not uncommon. Lupus erythematosus cells were found in vivo in the pleural of an elderly patient who had received procainamide (Pronestyl) hydrochloride (2 gm daily) for nine months. Patients who initially have pleural effusions while receiving drugs capable of inducing lupus erythematosus should have the fluid analyzed for lupus erythematosus cells to help clarify the cause of the effusion.

Aged↗
PubMed1976

Clinical experience using a small-gauge needle for arterial puncture.

The present study was undertaken to ascertain the feasibility of using a 25-gauge needle for arterial punctures. A total of 11,500 arterial punctures were performed over the past four years by this technique without any major complication. Repeated arterial punctures were well tolerated by all patients, and the necessity for indwelling arterial catheters was almost totally eliminated during this period of study.

Arteries↗
PubMed1975

Dextran 40: another cause of drug-induced noncardiogenic pulmonary edema.

Drug-induced noncardiogenic pulmonary edema occurred in a previously patient receiving dextran 40. Dextran 40 should be considered another etiologic factor of drug-induced noncardiogenic pulmonary edema when this syndrome occurs in the absence of known precipitating causes such as shock, aspiration, and overwhelming pneumonia.

Adult↗