HALOTHANE AND THE LIVER.
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Biomedical subjects
Publications and source records attributed to S SHERLOCK.
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Features of biliary obstruction were seen in 57 of 300 cases of post-necrotic cirrhosis but gave rise to real diagnostic difficulty in only 11 cases. The paper deals with the recognition and possible pathogenesis of this syndrome.
This is a clinical study of 81 patients (32 male and 49 female), who are not alcoholics, with jaundice of hepato-cellular type lasting longer than three months. Forty-nine of these patients were under 21 years of age. The natural history of the condition and the response to corticosteroid therapy is described; good symptomatic relief can be achieved with corticosteroids but they do not seem to prolong life. The aetiology is discussed with special reference to the relationship to viral hepatitis, to systemic lupus erythematosus, and to other disturbances of immunity.
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