Transport of amino acids by slices of rat-kidney cortex.
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Biomedical subjects
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During incubation with galactose, galactosemic leukocytes accumulated more galactose-l-phosphate than did normal leukocytes. Concomitant determination of glucose oxidation, with C(14) glucose, revealed no inhibition of the hexosemonophosphate pathway. These results are at variance with recent studies in rat lens tissue, which suggests that intracellular galactose-1-phosphate depressed glucose-6-phosphate dehydrogenase activity and the oxidative pathway.
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Menthol or menthone, or both, like progesterone, have been shown to have the following biological activities: (i) an inhibitory action on liver and kidney aldehyde dehydrogenase activity which, under certain circumstances, is reflected in an increased rate of oxidation of D-galactose, and (ii) a stimulatory effect on the oxidation of D-galactose by two prepubertal congenitally galactosemic subjects.
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