Biomedical subjects
Publications and source records attributed to S S Thatcher.
Hysteroscopic methods of tubal occlusion have not satisfied the criteria of an ideal contraceptive, although this technology still appears to be evolving. The aforementioned studies report the success and complication rates of very experienced hysteroscopists. A good potential exists for these techniques, but their widespread use will not come before greater experience and familiarity with the basics of hysteroscopy.
Human male pre-embryos were identified by means of DNA-DNA in-situ hybridisation with a commercially available DNA probe for Y-chromosome DNA. This method could lead to prenatal diagnosis of genetic disorders based on small numbers of cells that are not necessarily in division, such as cells obtained from a pre-embryo during the course of in-vitro fertilisation therapy.
The development of in-vitro fertilization (IVF) and embryo transfer (ET) as a treatment for certain forms of infertility has emphasized the need for more information on why so many preimplantation embryos fail to develop beyond the very early cleavage stages. Analysis of nuclei from embryos that had ceased to grow or that were morphologically abnormal was carried out using one of two techniques: measurement of the DNA content of their nuclei, or observation of the number of Y chromosomes per nucleus. It was found that there was a correlation between the length of time in culture and abnormal development of polyploidy in a number of the cells. On the other hand, a small proportion of polyploid cells observed in a morphologically normal expanded blastocyst probably represents the normal precursors of polyploid trophoblast cells as observed in other mammalian species.
Standard indexes and classification systems are frequently overly complicated and inappropriate for organizing copies of articles and reprints in a personal literature file. Based on an analysis of the tables of contents from 11 publications in the field of obstetrics and gynecology, a classification system has been developed. The system allows for individual needs in categorizing subspecialty interests and for new developments in the field.
Uterine stromatosis is an uncommon intramyometrial lesion. The present study reviews the clinicopathologic aspects of 33 cases, 9 of which were treated at The Johns Hopkins Hospital, whereas 24 were referred to the gynecologic pathology laboratory. In the series it was noted that progesterone therapy was able to control the spread of the condition and to cause regression of extrauterine disease for periods up to 9 years. Criteria for the diagnosis of malignancy in stromatosis are discussed.