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Biomedical subjects

S S Socransky

Publications and source records attributed to S S Socransky.

At least 217 records · Page 12Linked to original sources
PubMed1976

Importance of Actinomyces and certain gram-negative anaerobic organisms in the transformation of lymphocytes from patients with periodontal disease.

Dental plaque deposits are known to be potent stimulants of lymphocyte transformation in patients with periodontal disease but not in normal subjects. Since plaque deposits consist mainly of whole bacteria, the cell walls of the most commonly found organisms in plaque were tested for their capacity to induce lymphocyte transformation. There was a direct correlation between the severity of peridontal disease and the amount of transformation induced by the cell walls of oral bacteria and by solubilized dental plaque. Cord blood leukocytes and lymphocytes from clinically normal people did not respond, which indicates that these stimulants are antigens rather than mitogens. Of the eleven bacteria tested, four members of the family Actinomycetaceae (Actinomyces viscosus, A. israelii, A. naeslundii, and Arachnia propionica), the related Propionibacterium acnes, and an anaerobic gram-negative anaerobic rod (27N). The high prevalence of the former organisms in the mature dental plaque that forms around the gingival crevice area and the potent efficacy with which they stimulate lymphocytes indicates that Actinomyces and certain gram-negative anaerobes may be important etiological agents in chronic periodontal inflammation in man.

Actinomyces↗
PubMed1976

Effect of sonic treatment on pure cultures and aggregates of bacteria.

Pure cultures of a variety of bacteria were treated with ultrasonic energy using a sonic probe. Fractions of organisms killed at different sonic energies were calculated, and Streptococcus mutans was 600 times more resistant than Fusobacterium nucleatum, the most sensitive organism tested. The effects of sonic treatment on aggregates of bacteria were examined, and the results were interpreted as a model of the events that probably occur during the sonic dispersion of dental plaque.

Actinomyces↗
PubMed1969

Morphological and biochemical differentiation of three types of small oral spirochetes.

THIRTY STRAINS OF HUMAN ORAL ANAEROBIC SPIROCHETES WERE ISOLATED IN THREE DIFFERENT MEDIA: veal heart infusion-ascitic fluid, Spirolate-Brain Heart Infusion-rabbit serum, and supplemented PPLO broth. The morphological and biochemical characteristics of the isolates permitted their differentiation into three distinct species: Treponema denticola, T. macrodentium, and T. oralis (proposed new species). These species could be differentiated as follows. Organisms of the T. denticola type had a "2-4-2" axial fibril relationship as determined by electron microscopy, required serum for growth, did not utilize glucose or lactate, and produced indole, ammonia, acetate, and lactate as end products. T. macrodentium had a "1-2-1" axial fibril relationship, did not require serum, utilized glucose but not lactate, did not produce indole or ammonia, and produced formate, acetate, lactate, and succinate as acid end products. T. oralis had a "1-2-1" axial fibril relationship, required serum for growth, utilized lactate but not glucose, produced indole but not ammonia, and produced propionate and acetate as acid end products.

Culture Media↗