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Biomedical subjects

S S Moorthy

Publications and source records attributed to S S Moorthy.

At least 37 records · Page 2Linked to original sources

Resistance to vecuronium in patients with cerebral palsy.

To determine the electromyographic response of patients with cerebral palsy to vecuronium, 10 children (mean age, 6 yr 10 mo) without cerebral palsy and 11 children with cerebral palsy (mean age, 10 yr 3 mo) were studied. All patients were undergoing abdominal or orthopedic surgery and were anesthetized with isoflurane and nitrous oxide. The time from intravenous administration of 0.1 mg/kg of vecuronium to 25% recovery of control twitch height was 43.9 +/- 5.3 and 18.9 +/- 1.7 min (mean +/- SEM) in children without and with cerebral palsy, respectively (P less than 0.01). The authors conclude that patients with cerebral palsy are either resistant to vecuronium or have a rapid clearance as evidenced by the rapid recovery from neuromuscular blockade.

Anesthesia, Intravenous↗

Hypoglycemia following bilateral adrenalectomy for pheochromocytoma.

Severe hypoglycemia with delayed emergence occurred in a 12-yr-old boy following bilateral adrenalectomy for pheochromocytoma. Hypoglycemia after resection of pheochromocytoma may be due to release of insulin from the beta cells of the pancreas due to sudden withdrawal of catecholamines. Beta blockade with the use of propranolol impairs both hepatic glucose production and glucagon secretion mechanism. For early detection and treatment of hypoglycemia, perioperative blood glucose monitoring is important in patients undergoing adrenalectomy for pheochromocytoma.

Adrenal Gland Neoplasms↗