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Biomedical subjects

S S Krylov

Publications and source records attributed to S S Krylov.

32 records · Page 2Linked to original sources
PubMedDate not supplied

[Effect of M-and N-cholinolytics on the content of Ca2+ in synaptosomes and metabolism of phosphoinositols in the rat brain].

M-cholinolytics benactyzine and glypine increased a permeability of neurone membranes for Ca2+, producing the ion accumulation in synaptosomes. N-cholinolytic thropacin did not exhibit this effect and diphacyl caused similar to the M-cholinolytics but only slight effect on the Ca2+ content. The M-cholinolytics increased phosphoinositol turnover in rat brain, while the N-cholinolytics decreased its metabolism. These data obtained suggest that the M-cholinolytics interact selectively with phosphoinositols of neurone membranes affecting the affinity of phosphoinositols to two-valent cations and elevating the ability of Ca2+ to penetrate across neuronal membranes.

Animals↗
PubMedDate not supplied

[Pharmacology of prooxen].

Prooxen--9-(3-dimethylaminopropyliden) xanthene--administered in small doses (0.05-0.1 mg/kg) produces a central and peripheral adrenosensibilizing effect, diminishes the duration of hexenal sleep, disturbs the differentiation, and causes appearance of intersignal reactions in experiments with conditioned reflexes. The drug exerts an antireserpine action. In large doses (5 mg/kg and over) it displays a tranquilizing action, prolongs the narcotic action of hexenal and chloral hydrate. LD50 and LD100 of prooxen in mice are 280 and 350 mg/kg, respectively. As compared to damilen, prooxen exerts a more pronounced tranquilizing action, possesses less toxicity and less central M-cholinolytic activity.

Amitriptyline↗