Search PubMed⌕ Search

Biomedical subjects

S S Kantha

Publications and source records attributed to S S Kantha.

32 records · Page 2Linked to original sources

Albert Einstein's dyslexia and the significance of Brodmann Area 39 of his left cerebral cortex.

By his own admission, Albert Einstein, 'started to talk comparatively late ... certainly not younger than three', and also had 'poor memory of words', during his childhood years. If lesions in Brodmann Area 39 of the cerebral hemisphere results in dyslexia, the 1985 report on the study of Einstein's brain that the neuron:glial ratio of Area 39 in the left cerebral hemisphere of the physicist was significantly smaller than that of the control values, provides a neuroanatomical clue to Einstein's childhood dyslexia. Though not discrediting this finding, some questions are raised in this paper regarding the controls employed in this 1985 report (1).

Cerebral Cortex↗

Clues to prolific productivity among prominent scientists.

In a survey based on the biographical sketches, obituary notes and eulogies of notable scientists, eight were identified as belonging to an elite group, having authored more than 1000 research publications, which include books, monographs and patents. They were, in chronological order, Thomas Alva Edison, Paul Karrer, Margaret Mead, Giulio Natta, Hans Selye, Herbert C Brown, Tetsuji Kametani and Carl Djerassi. Among these, Karrer, Natta and Brown were Nobelists in chemistry. Four criteria which can be identified as clues to their prolific productivity are, 1) enthusiasm for compulsive work and eccentric life style, 2) physical and/or environmental handicap, 3) pioneering efforts in a new research field, and 4) selection of research area, predominantly organic chemistry.

Efficiency↗

Charles Darwin's anthropological observations on Ceylonese.

In his 1871 work, The Descent of Man and Selection in Relation to Sex. Darwin has made three anthropological observations pertaining to the nose, beard and polygamy in Ceylonese. He never visited Ceylon, and his observations were based on the works of Sir J. Emerson Tennent (1859) and Sir J. Lubbock (1865).

Anthropology↗

A centennial review; the 1890 tetanus antitoxin paper of von Behring and Kitasato and the related developments.

The significance of the 1890 tetanus antitoxin paper by von Behring and Kitasato in the development of a new discipline, immunology, is reviewed. The possible reasons why Kitasato lost the first Nobel Prize for medicine to von Behring are presented. These are as follows: (1) The Nobel selection committee literally interpreted Alfred Nobel's will to award the prize to "the person who has made the most important discovery." (2) In the late 19th century, diphtheria was a serious contagious disease which claimed many thousands of lives in the Europe and America; and von Behring's solely authored paper on diphtheria antitoxin clinched the award for him. (3) The merit of tetanus antitoxin to humans, which was the focal point of the 1890 paper on tetanus antitoxin jointly authored by von Behring and Kitasato, was not recognized at the time of the award in 1901; it became apparent only during the First World War.

Allergy and Immunology↗

Nutrition and health in China, 1949 to 1989.

Since the establishment of a new social order in 1949, China's attempts to feed and nurture its large population has been a topic of serious study in many disciplines. This review focuses on dietary sources of Chinese population and incidence, increase and decline of important diet related health disorders in China during the last four decades. Literature published since 1949 on goiter, rickets, riboflavin deficiency, beri beri, vision impairment, favism, cancer, atherosclerosis and coronary heart disease, hypertension, dental and smoking related diseases, diabetes mellitus, pancreatitis, lactose intolerance, mineral deficiency, Kashin-Beck disease, parasitic diseases and genetic disorders are reviewed. Also presented selectively are reports related to ethnodietetics, health care, maternal health and pediatric care as well as longevity. In the 1980s, total caloric intake of Chinese population showed a 19% increase on a daily basis from that of late 1940s. In overall terms, plant derived foods supplied 93% of energy, 87% of protein and 55% of fat to the Chinese. Among the animal foods, pork remains the most common and least expensive form of meat, contributing more than 90% of China's total meat production excluding poultry and fish. In 1949, the life expectancy in China was only 36 years. In early 1980s, it has increased to 68 years. This increase in life expectancy is attributed mostly to improved nutrition and lowering of mortality due to decrease in infectious diseases. Though population, disease and mortality statistics of modern China are spotty and sometimes questionable, common consensus among the researchers is that since 1949 the public health situation in China has improved tremendously.

China↗

A review of Nobel prizes in medicine or physiology, 1901-87.

This review examines the awards of Nobel Prizes for Medicine or Physiology discipline between 1901 and 1987, in order to evaluate the advances made in biomedical sciences in the twentieth century. A total of 78 awards had been made amounting to 144 laureates. Countrywise, scientists from the USA lead the tally of Nobelists with 62 laureates, followed by those from Britain and Germany. In the first quarter (1901-25), majority of the awards were given to pioneering studies in microbiology and physiology. Following three decades (1926-55) show the emergence of biochemists as preferred winners with many of the nutrition-related discoveries receiving the recognition. During and immediately after the Second World War (between 1939 and 1957), pharmacology related studies were also awarded Nobel merit. Molecular biology, genetics and immunology had become the prime areas for recipients during the last three decades beginning with 1958. Apart from these four distinct speciality areas, classic discoveries in the fields of neurosciences and behavior, clinical medicine, experimental biology endocrinology had also been recognized at regular intervals.

History, 20th Century↗

Hideyo Noguchi's research on yellow fever (1918-1928) in the pre-electron microscopic era.

One of the low points in Hideyo Noguchi's career as a pioneer medical microbiologist was his investigations on yellow fever between 1918 and 1924 in Central and South America. His discovery that spirochete Leptospira icteroides was the causative pathogen of yellow fever was discredited in 1927. This paper evaluates the situation under which Noguchi conducted his experiments and assesses the causes which might have resulted in his erroneous interpretation in the pre-electron microscopic era. Even 60 years after Noguchi's untimely death, much remains to be known about the virulence of pathogenic strains of yellow fever.

Africa, Western↗

Is somnambulism a distinct disorder of humans and not seen in non-human primates?

Though somnambulism (sleepwalking) is a well-recognized sleep disorder in humans, a biomedical literature search in Medline and Primate Literature bibliographic databases showed no publications on sleepwalking in non-human primates. From this finding, two inferences can be made. First is that somnambulism may be present in non-human primates; but due to limitations in expertise and methodological resources as well as narrow focus of research interest, until now researchers have not detected it in wild and/or captive conditions. Second, somnambulism does not exist in non-human primates including apes (chimpanzee, gorilla, orang-utan and gibbon); and thus, it is a unique behavioral disorder present only in humans. It is premature to conclude which of these two inferences is correct. In Jane Goodall's view, sleepwalking behavior is absent in chimpanzees. If further field observations can confirm Goodall's assertion that somnambulism is indeed absent in chimpanzees, it will be of evolutionary and medical interest to know why this parasomnic behavior became established in humans during the past 5.5 million years or so.

Animals↗

Dietary effects of fish oils on human health: a review of recent studies.

The beneficial effects in humans of ingesting fish oils have attracted much attention among medical scientists and nutritionists recently. Human studies conducted in populations of Eskimos, Japanese, and Caucasians since 1970 are reviewed in this paper. The evidence shows that a diet rich in omega-3 fatty acids significantly reduces plasma cholesterol and triglyceride levels, improves fat tolerance, prolongs bleeding times, reduces platelet counts, and decreases platelet adhesiveness.

Blood Coagulation↗

Fish-eating Eskimos?

Explore the source record for details and available documents.

Animals↗