Biomedical subjects
Publications and source records attributed to S S Gambarov.
Altogether 63 neonates whose mothers had experienced acute respiratory diseases during pregnancy were examined. The data obtained made it possible to include the children born to mothers with a history of acute respiratory diseases in the III trimester of pregnancy into the risk group of infectious process development.
Using a modified model, 16 patients with systemic lupus erythematosus were examined for the activity of nonspecific Con A-induced suppressors with the aid of different test systems. The suppressors of both patients and donors were employed. The proliferation of the test culture lymphocytes appeared to be activated. The immunogenetic abnormalities indicated seem likely to be related to extreme activity of the countersuppressor cells blocking the function of the suppressors, correlating with the clinical picture of the disease.
B-activin blocks the effect of concanavalin A-induced human T-suppressors, without influencing the process of their induction.
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It has been shown that partial hepatectomy inhibits the induction of cells exerting a suppressant effect on the development of humoral immune response.
The suppressive effect of the bone marrow T-cells activated by histocompatibility antigens on antibody formation was studied. The bone marrow of CBA mice was found to contain the thymus-dependent lymphocytes which underwent hyperactivation after the repeated transfers to F1 recipients and acquired the capacity ot inhibit the development of cooperative immune response to sheep erythrocytes. Pretreatment of the bone marrow cells with antithymocyte globulin and complement prevented the suppression.
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Functional activity of B- and T-cells was studied in mice during the growth of the inoculated tumours; it appeared that in the course of the tumour growth the capacity of B- and T-cells to the interaction in the immunization with sheep erythrocytes was disturbed. B-cells were affected earlier than T-cells.
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Bone marrow cells (0,5-10(6)) of female mice of CBA or C57BL strains were injected intravenously to lethally irradiated CBA, C57BL/6, (femaleCBA X maleC57BL/6)F1 and (femaleC57BL/6 X maleCBA)F1 mice. Spleen of recipients as assayed for colony count on the 9th day after bone marrow transplantation by the method of Till and McCullouch. Stem cells of CBA mice demonstrated failure of allogenic inhibition in (CBA X C57BL/6)F1 hybrid mice and formed the same number of colonies as in the spleen of syngenic recipients. The level of allogenic inhibition of CBA stem cells transplanted to (C57BL/6 X X CBA)F1 hybrid mice was 50%. Bone marrow cells of C57BL/6 mice formed colonies in spleen of (CBA X C57BL/6)F1 mice at least in 20 times less than in syngenic combination. In the transplantation of bone marrow from C57BL/6 mice to (C57BL/6 X CBA)F1 hybrid mice the allogenic inhibition was less pronounced (77-85%) as compared with the transfer of cells to (CBA X C57BL/6)F1 hybrid mice (95%). The sex of a recipient did not influence the number of formed colonies. The different level of allogenic inhibition of parental stem cells can not be explained by the effect of linkage with sex as the female of reciprocal hybrid mice have identical structure of sex chromosomes (X(CBA)XC57BL/6). The data obtained indicate that the maternal effect affects allogenic inhibition of stem cells in parent--F1 system. It is possible that the maternal influence may be determined by cytoplasmic factors of inheritance which affect the expressivity of recessive genes Hh, controlling the inheritance of specific haematopoietic cell antigens.
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The transfer of lymphocytes together with sheep erythrocytes from partially hepatectomized mice to syngenous lethally irradiated mice (CAB and C57BL) increased the number of antibody forming cells in the recipient's spleen. The lymphocytes of CBA mice acquired this ability much earlier after the operation (in 4 hours) than those of the C57BL mice (in 17 hours). After the transfer of lymphocytes in the semisyngenous system there was a decrease of antibody forming cells during subsequent recipient's immunization with sheep erythrocytes; this was the result of the graft versus host reaction. The latter reaction was less marked in the operated than in control mice. These changes also occurred earlier after the operation in the CBA than in C57BL mice.
The effect of the interaction between lymphocytes from tumor-bearing mice and stem cells was studied. It was found that in the process of tumor growth the property of lymphocytes to inactivate nonsyngeneic stem cells was not impaired. At the same time, during the process of tumor growth the property of lymphocytes to induce redifferentiation of syngeneic hemopoietic stem cells and to render a stimulating effect on the colony-forming activity of stem cells of the bone marrow is impaired under conditions of a manifested allogenic inhibition.
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