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Biomedical subjects

S S Coleman

Publications and source records attributed to S S Coleman.

At least 19 recordsLinked to original sources
PubMed2001

Triple innominate osteotomy in young adults for the treatment of acetabular dysplasia: a 9-year follow-up study.

Fifty patients who underwent 60 triple innominate osteotomies were reviewed radiographically and clinically using a modified Harris hip score (HHS). Average patient age was 26 years (range: 13-48 years). At average 9-year follow-up (range: 5-14 years), 12 (20%) hips had been converted to total hip arthroplasty (THA) and 4 (7%) hips had incapacitating pain. Sixteen (27%) hips were considered failures. Average modified HHS at final follow-up was 67 (range: 28-91). Forty-nine (98%) of 50 patients reported they would recommend the procedure to others in the same situation. Radiographically, there was significant improvement in the center-to-edge angle of Wiberg and the acetabular angle of Sharp. There also was a statistically significant relationship between failure of the osteotomy and severity of preexisting hip arthrosis as measured by the Tonnis criteria. The results demonstrate triple innominate osteotomy was effective in eliminating pain, but the fact that 27% of hips required or will require THA indicates results may deteriorate with time.

Acetabulum↗
PubMed1999

Detection of apoptotic cells in vitro: a practical standardized experimental protocol using human fibroblasts for initial laboratory studies.

This technical report presents a practical experimental protocol using human fibroblasts that is useful for initiating in situ methods for detection of apoptotic cells in vitro. The protocol details the growth of cells in multichamber wells, and includes a negative control, two positive controls, and untreated fibroblasts to be evaluated for apoptosis localization. Technical tips on handling of solutions, cell culture designs, and separation of slides by treatment are valuable steps for the laboratory beginning such studies. The methods proposed are both time and cost effective.

Apoptosis↗
PubMed1999

Long-term follow-up of persistent humeral shaft non-unions treated with tricortical bone grafting and compression plating.

Three percent of all fractures occur in the humeral shaft. A very high union rate is achieved with nonoperative treatment. When non-unions occur, however, they are often very difficult to treat, and often require multiple procedures to achieve union. Even with multiple procedures, true pseudoarthroses have only a 59% union rate10. We conducted a retrospective study of ten patients having persistent non-union of the humeral shaft, three of whom had a true pseudoarthrosis. An patients were treated with a compression plate and a tricortical iliac crest bone graft anchored rigidly across the fracture site with two screws applied at 90 degrees to the plate. A solid union was achieved in all ten (100%) patients.

Adult↗
PubMed1997

Colonna arthroplasty with concomitant femoral shortening and rotational osteotomy. Long-term results.

The results of Colonna capsular arthroplasty in twenty-two hips in twenty patients were reviewed. All twenty patients were at least five years old at the time of the operation, which was performed for either complete dislocation or marked subluxation of the hip. None were candidates for reconstructive procedures designed to preserve articular cartilage. The mean age at the time of the Colonna arthroplasty was nine years and three months (range, five years to fifteen years and two months), and the mean duration of follow-up was sixteen years (range, six to thirty-two years). At the most recent follow-up examination, the mean Harris hip score, for the twenty-one hips for which it was available, was 82 points (range, 52 to 98 points), the patients had improved gait, and there was marked improvement in the radiographic appearance of the hip according to the classification system of Severin. Thirteen hips in twelve patients had concomitant femoral shortening and rotational osteotomy at the time of the Colonna arthroplasty, and none of these patients who did not have evidence of avascular necrosis of the capital femoral epiphysis preoperatively had it postoperatively. Three hips that did not have concomitant femoral shortening had evidence of new-onset avascular necrosis after the Colonna arthroplasty. Concomitant femoral shortening and rotational osteotomy allowed the operation to be performed without preoperative traction, dramatically reduced the need for a subsequent rotational femoral osteotomy, and reduced the prevalence of postoperative avascular necrosis of the capital femoral epiphysis.

Adolescent↗
PubMed1997

Pemberton pericapsular osteotomy to treat a dysplastic hip in cerebral palsy.

We reviewed the results of Pemberton pericapsular osteotomy in nineteen hips (fifteen patients) that were subluxated (fifteen hips) or dislocated (two hips) or had severe acetabular dysplasia (two hips) secondary to spastic cerebral palsy. At least one concomitant procedure was performed in fifteen hips. These procedures included an intertrochanteric osteotomy to correct excessive femoral anteversion or valgus deformity of the neck-shaft angle (thirteen hips), a soft-tissue release (nine hips), and an open reduction (three hips). Four hips had no concomitant procedure. Five of the nineteen hips were painful preoperatively. The average age of the patients at the time of the index operation was seven years and nine months (range, three years and five months to twelve years and three months). The average duration of follow-up was ten years and nine months (range, three years and one month to nineteen years and nine months). All osteotomy sites healed without complications. At the latest follow-up examination, all of the hips were pain-free and satisfactorily reduced and none of the patients had deterioration in function. The average center-edge angle was -5 degrees (range, -45 to 18 degrees) preoperatively and 38 degrees (range, 17 to 53 degrees) at the latest follow-up examination. The average migration index of Reimers was 55 per cent (range, 30 to 100 per cent) preoperatively compared with 12 per cent (range, 0 to 46 per cent) at the latest follow-up examination. Sixteen of the nineteen hips were followed until closure of the triradiate cartilage. There were no instances of posterior uncovering or osteonecrosis of the femoral head or premature closure of the triradiate physeal cartilage leading to deficient acetabular coverage. Our results suggest that good clinical and radiographic results can be achieved with the Pemberton pericapsular osteotomy, with simultaneous intertrochanteric osteotomy and soft-tissue release when indicated, as treatment for subluxation or dislocation of the hip or acetabular dysplasia in cerebral palsy.

Cerebral Palsy↗
PubMed1996

Detection of Vibrio vulnificus biotypes 1 and 2 in eels and oysters by PCR amplification.

DNA extraction procedures and PCR conditions to detect Vibrio vulnificus cells naturally occurring in oysters were developed. In addition, PCR amplification of V. vulnificus from oysters seeded with biotype 1 cells was demonstrated. By the methods described, V. vulnificus cells on a medium (colistin-polymyxin B-cellobiose agar) selective for this pathogen were detectable in oysters harvested in January and March, containing no culturable cells (< 67 CFU/g), as well as in oysters harvested in May and June, containing culturable cells. It was possible to complete DNA extraction, PCR, and gel electrophoresis within 10 h by using the protocol described for oysters. V. vulnificus biotype 2 cells were also detected in eel tissues that had been infected with this strain and subsequently preserved in formalin. The protocol used for detection of V. vulnificus cells in eels required less than 5 h to complete. Optimum MgCl2 concentrations for the PCR of V. vulnificus from oysters and eels were different, although the same primer pair was used for both. This is the first report on the detection of cells of V. vulnificus naturally present in shellfish and represents a potentially powerful method for monitoring this important human and eel pathogen.

Animals↗
PubMed1993

Pemberton osteotomy for residual acetabular dysplasia in children who have congenital dislocation of the hip.

We reviewed the results for fifty-two hips in forty-two patients who had had a Pemberton pericapsular osteotomy between 1968 and 1984 as treatment for residual acetabular dysplasia of the hip. The average age of the patients at the time of the osteotomy was four years. The average duration of follow-up was ten years. At the time of the most recent follow-up, forty-two of the fifty-two hips had a rating of Severin class IA, an essentially normally developed hip. The results of the Pemberton osteotomy were unpredictable if there had been necrosis of the femoral head (without infection) preoperatively. We believe that the Pemberton osteotomy is a safe, effective procedure for the treatment of acetabular dysplasia in patients who have congenital dislocation of the hip.

Acetabulum↗
PubMed1991

The present attitude toward the biology and technology of limb lengthening.

Over the past ten years, many technical innovations and biologic concepts have appeared as they relate to the lengthening of long bones. Each of these has had a substantial influence upon the approach to the treatment of major discrepancies in limb length and angular deformities. It is the purpose of this paper to present these issues as objectively as possible so that the reader can put them into proper perspective, recognizing that there will be some degree of bias in the implementation of some of the technical devices. To appreciate the utility of these techniques, it is necessary to understand the biologic foundation of each method as well as its advantages and disadvantages.

Bone Lengthening↗
PubMed1990

The value of preliminary traction in the treatment of congenital dislocation of the hip.

In forty-one children who had forty-seven congenitally dislocated hips, the results of attempted closed reduction with general anesthesia, but without preliminary traction, were studied. Twenty (43 per cent) of the hips could not be reduced closed, and an open reduction was needed. After the reduction, all of the involved hips were immobilized in the so-called human position (marked flexion and slight abduction). At a minimum follow-up of two years, osteonecrosis of the femoral head had developed in only two hips (4 per cent). Patients who were more than one year old when the hip was reduced had a higher incidence of osteonecrosis of the femoral head and were more likely to need reconstructive procedures later. Patients who were more than eighteen months old at the time of the attempted closed reduction were more likely to need an open reduction of the hip. Treatment of congenital dislocation of the hip in young children remains an extremely complex problem. It has not been clearly established that the use of preliminary traction decreases the incidence of osteonecrosis of the femoral head or improves the outcome of treatment. In our experience, uncomplicated (non-teratological, postnatal) congenital dislocation of the hip has been safely treated with either open or closed reduction without preliminary traction in patients who were younger than two years old, provided that the reduction could be obtained without excessive force.

Female↗
PubMed1987

Subluxation of the femoral head in coxa plana.

Twenty-two patients who had severe coxa plana had closed reduction for lateral subluxation of the femoral head, as determined radiographically. All had painful limitation of motion of the hip that prevented proper positioning of the femoral head using a brace. The average age when the patients were first seen was eight years and six months. General anesthesia was required in order to obtain the reduction, and percutaneous tenotomy of the adductor longus was done whenever necessary. After the reduction, a Petrie cast was worn for several months. The length of follow-up averaged three years and eight months (range, two years to six years and eight months). Radiographic evaluation at the time of the last follow-up showed nine hips to be spherically congruent, twelve to be spherically congruent, and one to be incongruent. Thus, in 95 per cent of the hips, a congruent joint was obtained using this method of treatment. These results strongly support the concept that all treatment should be directed at containing the femoral head within the acetabulum during the clinically active phase of coxa plana.

Casts, Surgical↗