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Biomedical subjects

S Rumelt

Publications and source records attributed to S Rumelt.

47 records · Page 3Linked to original sources
PubMed1997

Silicone punctal plug migration resulting in dacryocystitis and canaliculitis.

PURPOSE: One of the modalities of treating dry eyes is punctal plugs. They are usually used for temporary occlusion of the lacrimal drainage system. Among the complications associated with silicone punctal plugs are extrusion, downward migration, irritation, and epiphora. To our knowledge, this is the first report of dacryocystitis and canaliculitis as a result of spontaneous migration of punctal plugs into the lacrimal drainage system. METHODS: We describe the sequelae of spontaneous migration of silicone punctal plugs into the lacrimal drainage system in two patients with dry eyes. RESULTS: In two patients, spontaneous migration of silicone punctal plugs into the canaliculus or the lacrimal sac, respectively, resulted in canaliculitis or dacryocystitis. CONCLUSION: Smaller sized newer generation punctal plugs were designed to facilitate insertion; however, this design also increases the likelihood of proximal migration within the lacrimal drainage system. The importance of monitoring patients after punctal-plug placement cannot be over-emphasized.

Adult↗
PubMed1996

Lenticular astigmatism after penetrating eye injury.

Lenticular astigmatism of 5.00 diopters developed after penetrating injury in the eye of a 16-year-old boy. Full visual acuity, refraction, and crystalline lens clarity remained stable for more than 2 years. The high astigmatism, in conjunction with a spherical cornea and posterior lens capsule striae, indicates the lenticular origin of the astigmatism.

Adolescent↗
PubMed1996

A donor corneal patch graft for an incompetent scleral flap following trabeculectomy.

Prolonged postoperative hypotony may complicate filtration surgery, especially in conjunction with mitomycin-C. Incompetence of the scleral flap is one of the etiologic factors of hypotony. A persistent leak from an incompetent or traumatized scleral flap may necessitate surgical intervention, including patching techniques. To the best of the authors' knowledge, the following is the first report on using a partial-thickness corneal allograft as a patch for an incompetent and leaking scleral flap.

Aged↗
PubMed1995

Corneal hydrops associated with vernal conjunctivitis as a presenting sign of keratoconus in children.

BACKGROUND: The onset of keratoconus usually coincides with adolescence, and may be associated with vernal conjunctivitis or other atopic conditions. In patients with vernal conjunctivitis, acute hydrops may be the presenting sign of keratoconus in preadolescence. METHODS: Review of ophthalmic clinical manifestations of three children with presenting symptoms and signs of acute corneal hydrops associated with vernal conjunctivitis. RESULTS: Three children, 5 to 11 years of age, presented with corneal hydrops associated with mild vernal conjunctivitis. In two of these children, vernal conjunctivitis was asymptomatic, and in one child the signs of vernal conjunctivitis appeared after the occurrence of hydrops. No other factors, including mechanical factors such as eye rubbing, were found to be related. CONCLUSIONS: The association of vernal conjunctivitis with keratoconus may contribute to the early occurrence of hydrops. Corneal hydrops in children may, therefore, indicate coexisting vernal conjunctivitis.

Child↗
PubMed1990

Growth of injured rabbit optic axons within their degenerating optic nerve.

Spontaneous growth of axons after injury is extremely limited in the mammalian central nervous system (CNS). It is now clear, however, that injured CNS axons can be induced to elongate when provided with a suitable environment. Thus injured CNS axons can elongate, but they do not do so unless their environment is altered. We now show apparent regenerative growth of injured optic axons. This growth is achieved in the adult rabbit optic nerve by the use of a combined treatment consisting of: (1) supplying soluble substances originating from growing axons to be injured rabbit optic nerves (Schwartz et al., Science, 228:600-603, 1985), and (2) application of low energy He-Ne laser irradiation, which appears to delay degenerative changes in the injured axons (Schwartz et al., Lasers Surg. Med., 7:51-55, 1985; Assia et al., Brain Res., 476:205-212, 1988). Two to 8 weeks after this treatment, unmyelinated and thinly myelinated axons are found at the lesion site and distal to it. Morphological and immunocytochemical evidence indicate that these thinly myelinated and unmyelinated axons are growing in close association with glial cells. Only these axons are identified as being growing axons. These newly growing axons transverse the site of injury and extend into the distal stump of the nerve, which contains degenerating axons. Axons of this type could be detected distal to the lesion only in nerves subjected to the combined treatment. No unmyelinated or thinly myelinated axons in association with glial cells were seen at 6 or 8 weeks postoperatively in nerves that were not treated, or in nerves in which the two stumps were completely disconnected. Two millimeters distal to the site of injury, the growing axons are confined to a compartment comprising 5%-30% of the cross section of the nerve. A temporal analysis indicates that axons have grown as far as 6 mm distal to the site of injury, by 8 weeks postoperatively. Anterograde labeling with horseradish peroxidase, injected intraocularly, indicates that some of these newly growing axons arise from retinal ganglion cells.

Animals↗
PubMed1988

Clearance of Serratia marcescens from blood in mice: role of hydrophobic versus mannose-sensitive interactions.

In the present study, we examined the potential roles of cell surface hydrophobicity and mannose-sensitive (MS) interactions in blood clearance of Serratia marcescens in mice. Hydrophobic strain RZ, partially hydrophobic mutant 3162, and nonhydrophobic mutant 3164 were coinoculated into BALB/c male mice, and blood samples were plated out at different time intervals; colonies of the three strains were distinguished by their different morphologies. All three strains were cleared from the blood stream at similar rates, despite their large relative differences in cell surface hydrophobicity. Clearance from blood was subsequently studied by coinoculating two clinical isolates which differ in their abilities to adhere via MS interactions. MS+ strain 1785 was cleared much more rapidly than MS- strain 3255; moreover, in the presence of D-mannose, clearance of strain 1785 was inhibited to a rate similar to that of MS- strain 3255. When D-glucose was substituted for D-mannose, inhibition was not observed. The results suggest that MS, rather than hydrophobic, interactions are primarily responsible for the rapid clearance of S. marcescens from blood observed.

Animals↗
PubMedDate not supplied

Computerized corneal topography of furrow corneal degeneration.

PURPOSE: To analyze the corneal topography features of furrow corneal degeneration. SETTING: Western Galilee-Nahariya Medical Center, Nahariya, Israel. METHODS: Computer-assisted corneal topography analysis of two patients with furrow corneal degeneration was obtained and studied. RESULTS: The typical appearance of circumferential peripheral thinning in the lucid interval between the limbus and corneal arcus indicated a clinical diagnosis of furrow corneal degeneration. The corneal topography maps showed central flattening and excentric localized steepening. A step of 1.50 diopters was seen central to the peripheral furrow. CONCLUSION: Keratometry and noncomputerized keratoscopy are insufficient methods of evaluating the topographic features of furrow corneal degeneration. Computer-assisted corneal topography showed steepening and central flattening that may be attributed to the thinned peripheral circumference.

Aged↗
PubMedDate not supplied

Silicone oil emulsification of the retinal surface.

A 35-year-old patient with cytomegalovirus (CMV) retinitis secondary to acquired immunodeficiency syndrome (AIDS) underwent pars plana vitrectomy and fluid-gas-silicone exchange for retinal detachment. Three weeks following surgery and additional laser photocoagulation, extensive retinal surface emulsification was noted. It masked the retinal surface and demonstrated shifting in subsequent examinations. This case stresses the importance of careful and close follow-up after pars plana vitrectomy and silicone oil injection. Silicone oil emulsification may in some cases require removal of the emulsified fluid or silicone oil exchange, but in others such as our case, shifting of the emulsified silicone oil may allow evaluation of the nonobscured retina.

AIDS-Related Opportunistic Infections↗