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Biomedical subjects

S Roman

Publications and source records attributed to S Roman.

122 records · Page 7Linked to original sources
PubMedDate not supplied

High levels of plasma von Willebrand factor in hyperthyroidism.

Both von Willebrand factor antigen and activity tested as ristocetin cofactor, were found to be increased in the 20 patients with hyperthyroidism, while changes detected on the 10 hypothyroid patients did not significantly differ from the mean values recorded in 19 healthy control subjects. It is considered that the high levels of endothelia-derived plasma von Willebrand factor in hyperthyroidism is the result of a long-standing stimulation of vascular endothelial cells by either a direct effect of thyroid hormones or by an excessive adrenergic activity. The present findings represent an important limitation in interpreting raised levels of plasma von Willebrand factor as a marker of endothelial injury or in terms of a thrombotic tendency.

Adult↗
PubMedDate not supplied

[Diagnostic elements of a right papyraceous ventricle. The value of nuclear magnetic resonance].

We are reporting the case of a young man presenting repeated syncopes linked to episodes of ventricular tachycardia. The rhythm disorders were due to the existence of a papyraceous right ventricle with concomitant involvement of the left ventricle disclosed during the etiological work-up. We are reporting, at this time, the usual diagnostic elements of this disease, but mostly original data provided by the nuclear magnetic resonance, as the clinical examination and the EKG are often less revealing except for late potentials always found in the arrhythmic form. The right, ventricular dysplasia and the papyraceous right ventricle represent two very close entities. Particular characteristics enable to differentiate them and also the differential diagnosis with other diseases are discussed by stressing the advantage of magnetic resonance imaging, a new method, non invasive, which lends itself well to the analysis of cardiac morphology.

Adult↗
PubMedDate not supplied

Increased plasma level of clotting factors VII and X in hyperlipoproteinemia.

When compared to values obtained in healthy normal-weight normolipidemic controls, the combined activities of clotting factors VII and XI, as well as serum cholinesterase were found to be significantly higher in hyperlipidemic and especially in hypertriglyceridemic subjects. The levels of the vitamin K-dependent clotting factors are positively correlated with the concentration of serum cholesterol, the logarithm of serum triacylglycerol level and serum cholinesterase activity. Based on these data as well as on previous observations concerning an increased plasma level of other liver secretion enzymes in endogenous hypertriglyceridemia, a possible interrelationship between accelerated turnover of lipoproteins, enhanced hepatic protein synthesis and thromboatherosclerosis is suggested.

Adult↗
PubMedDate not supplied

[Ketalar pivot anesthesia in cortisone-dependent patients].

On the basis of results obtained in a series of 6 patients with corticoid-dependency in whom 7 surgical interventions have been carried out the authors present the anesthesia technique on Ketalar pivot according to the following protocol: premedication with Diazepam and atropin; induction of anesthesia with Ketalar (2 mg/kg of body weight) and Pavulon 0,1 mg/kg of body weight); maintenance with Ketalar (1 mg/kg of body weight) at 10-15 minutes, and NO2/O2 4/2 at 1 minute. The cardiovascular stability was satisfactory. No fall in the value of blood pressure was noted.

Adrenal Cortex Hormones↗
PubMedDate not supplied

Antithrombin III in patients with prosthetic cardiac valves.

When compared to 40 control subjects and to 13 patients with mitral stenosis (8 of them commissurotomized) antithrombin III (AT III) activity, assessed by a clotting technique, was found to be slightly but significantly depressed in the 18 patients with prosthetic valves in mitral position. Decrease of AT III level occurred mainly in patients with metallic Björk-Shiley prostheses in whom mitral valve replacement had been performed more than 12 months before the investigation. Particularly low AT III activities were noted in the three patients who developed thromboembolic complications with lethal evolution. Impaired AT III activity in a patient with prosthetic cardiac valves might be considered as a marker of ongoing in vivo activation of coagulation. Such a finding should be a warning and an indication for intensifying the antithrombotic therapy.

Adult↗
PubMedDate not supplied

Antithrombin III deficiency in a Romanian family. Pathogenic role of concomitantly increased plasma level of clotting factors VII and X.

Antithrombin III deficiency in a Romanian family is presented. The propositus, a 27 year-old man, had a history of recurrent venous thrombosis and was found to present a plasma antithrombin III level of only 50% of the normal values. His mother and two of his five children had low antithrombin III levels but no episodes of venous thrombosis. In opposition to his family members, the propositus presented overweight, slight hypertriglyceridemia and displayed a high level of clotting factors VII and X. The findings suggest that development of thromboembolic disease in a subject with familial antithrombin III deficiency is enhanced by additional factors, for example by an increased plasma level of vitamin K-dependent clotting factors.

Adult↗
PubMedDate not supplied

[Direct relation between the significantly increased IgG specific antibody titer and the clinico-evolutive form in respiratory infections in infants and children. IgA and IgD levels in the evolution].

Of 69 children suffering from acute respiratory infections, with increased IgG titers 34 presented normal or high IgAs titers in the laryngotracheal exudate. All these patients had a favourable evolution. The other children with low IgAs levels or absent IgAs in the laryngotracheal exudate had a prolonged relapsing evolution, regardless of serum IgG levels. The presence of IgA 7S in the laryngotracheal exudate did not influence the course of the disease. As a conspicuous parallelism was observed between laryngotracheal exudate IgAs and serum IgA it was assumed that IgAs participates in the formation of serum IgA "mixtures". Increased IgD values were found in 34 of these patients, ten of whom presented respiratory allergy and recurrent infections.

Adolescent↗
PubMedDate not supplied

The role of spleen in the pathogeny of aplastic anemia related to increased number of CD3+ CD8+ FcR+ cells.

The role of spleen in the pathogeny of aplastic anemia (A.A.) related to excessive suppression, and the value of splenectomy in the treatment of this disorder is still debated and unclear. In an attempt to find out why some patients respond to surgery and others do not, an immunologic study was carried out in 16 patients with aplastic anemia. Lymphocytes surface markers CD3, CD4, CD8, HLA-DR, Fc receptors (FcR) and CD4/CD8 ratio were determined before and after splenectomy in the patients' peripheral blood, and in the spleen. In addition, the number of granulo-monocytic colony forming cells (GM-CFC) before and after splenectomy was estimated. Nine of the cases showed increased CD3+ CD8+ FcR+ cells, reversed CD4/CD8 ratios (both, in peripheral blood and in spleen), and a low number of GM-CFC. In all these cases, splenectomy induced an improvement of the clinical, hematological, and immunological parameters, thus suggesting that spleen represents an important "reservoir" for CD3+ CD8+ FcR+ cells, which seem to exert a suppressor effect on the hematopoietic progenitors. In splenectomized patients who did not respond to surgery, the pathogenic mechanism was probably related to defective help (3 cases with low values of CD4+ cells), to defective suppression (2 cases with decreased number of CD8+ cells), to a stem cell defect or a deficiency in the stem cell microenvironment (2 cases with normal helper/suppressor ratio). These observations support the conclusion that splenectomy is indicated and may be successful only when the phenotypic markers show an increased number of CD3+ CD8+ FcR+ cells.

Anemia, Aplastic↗
PubMedDate not supplied

Plasminogen activator inhibitor (PAI) in obese men and obese women.

When compared to plasma PAI activity noted in selected control normal-weight normolipidemic women (9.36 AU/ml +/- 1.2) and men (13.6 AU/ml +/- 1.96), this inhibitor of fibrinolysis was found to be significantly (p < 0.001) higher in gender-matched obese patients. Obese men younger than 45 years, however, displayed a plasma PAI activity (32.5 AU/ml +/- 5.45) significantly higher (p < 0.01) than that recorded in age-matched obese women (17.8 AU/ml +/- 2.25). No significant difference concerning PAI activity was noted between women older than 45 years (26.4 AU/ml +/- 3.66) and age-matched men (23.8 AU/ml +/- 3.29). High plasma PAI activity was accompanied by an increased resistance of plasma clots to exogenous t-PA induced fibrinolysis. Since PAI depleted plasma clots however displayed a weak resistance to t-PA induced fibrinolysis, it was concluded that plasma PAI may be the main, but not the only factor, responsible for the prolonged plasma clot lysis time in obese subjects.

Adult↗
PubMedDate not supplied

Lymphocyte subset reference ranges in Romanian adult Caucasians.

The paper reports the distribution of lymphocyte subpopulations in the Caucasian population of Romania. Investigations were carried out in cells bearing the following antigens: CD3 (T cells), CD19 (B cells), CD4 (T helper/inducer cells), CD8 (T suppressor/cytotoxic and some NK cells), and CD16 CD56 (NK cells). Reference values for the lymphocyte subpopulation were obtained from over 100 healthy Caucasian adult volunteers. Blood from these donors was analyzed using FACScan flow cytometer, Leuco-GATE, Simultest and FACS Lysing Solution, and SimulSET software. As an internal quality control, it was verified that %T+%B+%NK approximates 100% in all samples. The results presented here, obtained on healthy donors (51 males and 49 females), showed that there are no statistically significant variations of CD4/CD8 ratio related to sex or age, the mean value of this ratio (2.0 +/- 0.02) being similar to that reported by the West-European countries. Additional similarities were found when the relative percentage, mean +/- standard deviation (CD3 = 74.2 +/- 2.8; CD19 = 10.8 +/- 1.6; CD4 = 42.0 +/- 2.5; CD8 = 28.9 +/- 5.7; CD56 = 15.2 +/- 0.4) and the absolute cell number of the major peripheral blood mononuclear subsets established in our study were compared with other published results. This study was entirely supported by Becton Dickinson--Europe (Division Heidelberg, Germany).

Adolescent↗