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Biomedical subjects

S Rogers

Publications and source records attributed to S Rogers.

At least 325 records · Page 18Linked to original sources
PubMed1979

Comparison of photochemotherapy and dithranol in the treatment of chronic plaque psoriasis.

A two-centre trial has been carried out on 224 patients with chronic plaque psoriasis randomly allocated to treatment with a standard dithranol regimen of 8-methoxypsoralen and long-wave ultraviolet light (P.U.V.A.). Lesions in 91% of the 113 in the P.U.V.A. group cleared satisfactorily compared with 82% of 111 in the dithranol group, but clearing took longer (34.4 +/- 1.8 S.E. days) with P.U.V.A. than with dithranol (20.4 +/- 0.9 S.E. days). P.U.V.A. treatment took less patient-time and nurse-time and was more convenient and acceptable to the patients. Patients in whom lesions had failed to clear with dithranol, and some who had needed methotrexate for control, responded satisfactorily to P.U.V.A. A few patients who had failed on P.U.V.A. were treated with dithranol and responded to it. There is a case for the use of P.U.V.A. for patients who would otherwise require methotrexate and those who cannot be managed successfully with dithranol. There is also no reason to withhold P.U.V.A. in patients of 60 years or above with chronic plaque psoriasis. However, despite its superiority in terms of cost and patient acceptability, P.U.V.A. cannot be recommended as the first line of treatment for patients with uncomplicated, dithranol-responsive plaque psoriasis until there is more information on relapse-rate and toxicity.

Administration, Oral↗
PubMed1979

A psychometric and behavioral comparison of delinquents who were abused as children with their non-abused peers.

Investigated responses of abused and non-abused juvenile delinquents to Bell's Adjustment Inventory and Gough's California Psychological Inventory, and information with regard to several related behavioral measures. The Ss were 52 institutionalized adolescent males and females. Results indicated that the abused Ss scored significantly higher than the non-abused group on the Home Adjustment Scale (indicative of poorer adjustment) and significantly lower than the non-abused group on the Flexibility, Tolerance, and Socialization Scales. Subsequent analysis showed a significant interaction effect on the behavioral measure with regard to the number of runaway attempts; abused males made significantly more attempts than abused females and non-abused males and females.

Adolescent↗
PubMed1979

Galactose metabolism in isolated perfused suckling-rat liver.

The metabolic conversion of 1, 2, or 4 mM galactose to glucose was studied in isolated livers of suckling rats. Whereas galactose uptake during perfusion with 1 and 2 mM galactose was linear throughout the 90-min experiment, uptake was delayed for 35 min when 4 mM galactose was perfused. Studies with radioactive galactose revealed a parallel disappearance of galactose and the appearance of [14C]glucose; about 80% of the galactose taken up was converted to glucose. Galactose perfusion appeared to reduce the basal amount of glucose derived from substrates other than galactose. The specific activities in the galactose-perfused livers of the three major galactose metabolizing enzymes, galactokinase, galactose-1-phosphate uridylyltransferase, and uridine diphosphogalactose-4-epimerase, revealed that the transferase was significantly lower, whereas that of galactokinase and epimerase were significantly higher than in livers perfused without galactose. No meaningful changes were observed in the levels of either phosphorylated or uridylated hexoses in these studies.

Animal Population Groups↗
PubMed1978

A parasitological study on the chacma baboon (Papio ursinus) from the Northern Transvaal.

Baboons imported into Rhodesia from the Northern Transvaal proved to be heavily infected with intestinal protozoa and helminths. In fact, six protozoan species, one cestode and eight nematode species were recorded. A new concept in "identification graphs" is included in the paper which allows one to read off directly the species of strongyle eggs being passed by baboons in Southern Africa based upon length and breadth measurements of the eggs. Treatment of Balantidium coli and nematode infections of baboons is discussed as is the implication of some of these intestinal parasite infections in terms of potential human infection under natural conditions.

Animals↗
PubMed1978

Trans-delta-9-tetrahydrocannabinol: effects on macromolecular content of mouse liver tissue.

Mice were starved for 72 hours then injected with a total of 50 mg/kg THC over 48 hours during which time the animals were fed ad libitum. At the end of the 48 hours, the mice were sacrificed and the livers were analyzed quantitatively for DNA, RNA, protein, and glycogen. It was determined that the THC had no effect on the DNA or glycogen levels. The amount of RNA increased significantly when compared to controls while protein levels decreased by 50%.

Animals↗
PubMed1977

Observations on the diagnosis and treatment of schistosomiasis in an endemic area.

This article attempts to evaluate the criteria used in the diagnosis of schistosomiasis in an endemic bilharzial area. The discussion deals with the possible value of criteria such as egg recovery, rectal biopsy specimens, eosinophilia, hepatomegaly, and serological and skin tests. A rational approach to the treatment of patients with schistosomiasis is proposed and features such as probability of re-infection are taken into account.

Calcinosis↗
PubMed1977

Gastrointestinal side effects of clindamycin and ampicillin therapy.

Hospitalized patients who received clindamycin or ampicillin were evaluated for gastrointestinal side effects for a period of up to six weeks after therapy was discontinued. Of 104 patients receiving clindamycin therapy, 31 (29.8%) developed diarrhea, and two (1.9%) developed pseudomembranous colitis (PMC). Of 138 patients receiving ampicillin, 24 (17.3%) developed diarrhea, and one (0.7%) developed PMC. Diarrhea persisting for three days or more was noted in 13 (12.5%) of the patients receiving clindamycin and in seven (5.1%) of those receiving ampicillin. The tendency to develop diarrhea was positively correlated with serious illness, abdominal or pelvic sepsis, and total dosage of clindamycin. Examination of stools from a patient with PMC that was associated with clindamycin therapy showed a decrease in the number of anaerobic bacteria from the numbers found in stool cultures of normal controls. Those patients who did not develop diarrhea also had fewer anaerobic bacteria and coliform organisms. Lymphocytes from the patient with PMC were hyporeactive to phytohemagglutinin and hyperreactive to clindamycin.

Adult↗
PubMed1977

Giant multinucleated hepatocytes in an adult with chronic active hepatitis.

A case of an adult with chronic active hepatitis associated with giant multinucleated liver cells is presented. The giant liver cells in this case are widespread and the picture resembles neonatal hepatitis. The morphology, pathogenesis, and epidemiology of giant hepatocytes found in human neonates and adults and in experimental animals is discussed. Because the proliferative phase of giant hepatic cells is transient, this reaction may be more common than generally believed.

Adult↗