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Biomedical subjects

S Roche

Publications and source records attributed to S Roche.

66 records · Page 4Linked to original sources
PubMed1990

Diphtheritic polyneuritis in an elderly woman: clinical and neurophysiological follow-up.

A 71-year-old English lady initially presented with a bulbar paralysis and, six weeks later, developed a generalised sensori-motor neuropathy. Corynebacterium diphtheriae mitis was cultured from her throat swab. Despite a good clinical recovery at one month, nerve conduction velocity was at its lowest. As far as the authors are aware, this is one of the few cases of neurophysiological and clinical follow-up in a British subject with diphtheritic peripheral neuropathy. This case emphasises the importance of giving antitoxin early.

Adrenocorticotropic Hormone↗
PubMed1989

Gastrin and CCK-8 induce inositol 1,4,5-trisphosphate formation in rabbit gastric parietal cells.

The role of phosphoinositide turnover in the mediation of acid secretion was examined in an enriched preparation of isolated rabbit parietal cells (75%). Both gastrin and CCK-8 (octapeptide of cholecystokinin) stimulated [14C]aminopyrine (AP) uptake by cells (EC50 0.07 +/- 0.03 nM (gastrin) and 0.093 +/- 0.065 nM (CCK-8] and increased [3H]inositol phosphates cellular contents (EC50 0.142 +/- 0.016 nM (gastrin) and 0.116 +/- 0.027 nM (CCK-8] in a parallel fashion. In addition, the EC50 values for both phenomenon were quite similar to the Kd values obtained from binding experiments. HPLC analysis of the different [3H]inositol phosphates produced under gastrin or CCK-8 stimulation showed a 2-fold increase in [3H]Ins(1,4,5)P3 levels within 5 s with a concomitant increase in [3H]Ins(1,4)P2 content within 15 s. A low but significant rise in [3H]Ins(1,3,4,5)P4 and [3H]Ins(1,3,4)P3 cellular contents was also observed. No difference between gastrin- and CCK-8-induced inositol phosphates production could be shown. We can conclude that gastrin and CCK-8 display an identical profile of action, suggesting that they stimulate the acid secretory function of parietal cells through the same receptor site coupled to the Ins(1,4,5)P3 production.

Aminopyrine↗
PubMed1989

Relative efficacy of intravenous methylprednisolone and ACTH in the treatment of acute relapse in MS.

To compare the efficacy of high-dose intravenous methylprednisolone with intramuscular ACTH in the treatment of acute relapse in multiple sclerosis, we undertook a double-blind, randomized, controlled study involving 61 patients. There was a marked improvement in both groups in the course of the study, but no difference between them in either the rate of recovery or the final outcome. High-dose IV methylprednisolone is a safe alternative to ACTH in the management of acute relapse in MS.

Acute Disease↗
PubMed1988

Haemangiopericytic meningioma of the sacral canal: a case report.

A case of haemangiopericytic meningioma of the sacral canal in a 25 year old man, an uncommon tumour at a rare site, is described. The tumour was malignant and largely undifferentiated although there was light and electron microscopic evidence of dual differentiation in areas towards haemangiopericytoma and meningioma. The patient, with cauda equina syndrome, was treated by partial resection and post-operative radiotherapy and remains well 12 months after treatment.

Adult↗
PubMed1983

[Study of the course of development in 84 non-insulin-dependent diabetics over a 5-to-10-year period. Their therapeutic outcome].

The clinical, biological and therapeutic course of non-insulin-dependent (type II) diabetes mellitus was studied in 84 patients followed up for five to ten years. Three-quarters of these patients, who had had diabetes mellitus for approximately ten years in most cases, were well controlled although they remained overweight, presumably as a result of poor compliance with nutritional prescriptions. Disturbances in lipids were only incompletely corrected in 60% of patients. Arterial hypertension persisted in 15%. Oral therapy remained effective in 70% of patients. Among the 30% of patients given insulin, 13% were so treated because of renal failure. Notwithstanding the satisfactory control of diabetes mellitus, probably as a result of the persistence of other risk factors, micro and macroangiopathic complications occurred or worsened during the follow up period.

Adult↗
PubMed1982

Sweating sensitivity and capacity of women in relation to age.

Ten postmenopausal and ten younger women rested for 2 h in a 40 degrees C, 22.2-Torr vapor pressure environment. Sweating response was monitored by resistance hygrometry for onset, a platform balance for whole-body sweat rate, and five individual capsules for regional sweat rate. Other variables measured included forearm blood flow, heart rate (HR), mean skin (Tsk) and rectal (Tre) temperatures, sweat electrolytes (Na+ and K+), oxygen uptake, and plasma volume changes. Preliminary tests included maximal aerobic power (VO2max) and percent body fat. Heat stress did not elicit any significant differences in sweating response between age groups. Indices of heat strain, Tre and HR, were also similar for both groups. The only significant difference between younger and older women was a higher Na+ concentration in the forearm sweat of postmenopausal women. No thermoregulatory responses were related to age, but both sweat rate (r = 0.48) and peak Tsk (r = -0.43) were related to VO2max. For healthy, active, older women aging did not diminish the functional capacity of the sweating mechanism to cope with heat stress while resting in this specific thermal environment.

Adult↗