Effect of some therapeutic agents on the rabbit fetus.
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Biomedical subjects
Publications and source records attributed to S Robinson.
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BACKGROUND: The objective of the study was to examine the relationship between serum fasting insulin, insulin sensitivity S(i), cardiovascular risk factors, and asymptomatic early atherosclerosis in normotensive Type 2 diabetic subjects. METHODS: Specific insulin was measured using an enzyme-linked immunosorbent assay (ELISA) and insulin sensitivity was assessed with an insulin-modified frequently sampled intravenous glucose tolerance test (FSIVGTT). Early atherosclerotic change was assessed using carotid intima media thickness (IMT) and an arterial ultrasound score (AUS) measured by high-resolution B-mode ultrasound. RESULTS: On bivariate analysis, there was a positive correlation between S(i) and high density lipoprotein (HDL) cholesterol (r(s)=0.27, p<0.05), and a negative correlation between S(i) and body mass index (BMI) (r(s)=-0.42, p<0.001), HbA(1c) (r(s)=-0.29, p<0.05) and serum triglyceride (r(s)=-0.30, p<0.05). There was a positive correlation between carotid IMT and age (r(s)=0.41, p<0.0005), and a positive association with male sex (p<0.0001) as well as with smoking (p<0.0001). However, we found no correlation between carotid IMT and fasting specific insulin (r(s)=-0.04) or S(i) (r(s)=-0.08). On multiple regression analyses, only age and serum triglycerides appeared to be significant independent variables with respect to carotid IMT whereas age, male sex and smoking emerged jointly significant with respect to AUS. There were no independent associations between carotid IMT or AUS with other variables including using either fasting specific insulin or S(i) as markers on insulin resistance separately. CONCLUSION: Carotid IMT and AUS in Type 2 diabetes are closely associated with age, male sex and smoking. The relationships between serum insulin and insulin resistance with ultrasonically measured early arterial disease in Type 2 diabetes remain unclear.
This article presents a case study involving a challenging client on a pediatric rehabilitation unit, describes his impact on an interdisciplinary team that had recently been formed from two units from different hospitals, and discusses the resulting need for a team-building intervention for the new unit. The context of the problem, the client's case study, and a description of a series of seminars are presented and analyzed from a group developmental perspective.
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Little seems to have been written about health promotion in outpatients' departments. This article argues that outpatient nurses have the potential to play a significant part in promoting people's health. Outpatient nurses may be the first hospital nurses that an individual meets. What people observe and how they are treated may make a difference to both their experience of hospital care and their health. Outpatient nurses may have been perceived as the doctors' handmaidens of yesterday, but today they are evolving into an effective force for change. For example, evaluation of nurse-led outpatients' clinics is showing that they have the potential to complement doctor-led clinics and improve the healthcare experience of patients. It is argued that the health-promoting role of the outpatient nurse can be enhanced by a department that is a health-promoting environment.
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