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Biomedical subjects

S Robertson

Publications and source records attributed to S Robertson.

191 records · Page 11Linked to original sources
PubMedDate not supplied

Sodium pump activity, amino acid transport and long-term memory.

Long-term protein synthesis-dependent memory formation is shown to be inhibited by the non-metabolizable amino acid alpha-amino-isobutyrate (AIB) possibly through a process related to competition for uptake with amino acids necessary for protein synthesis specific to long-term memory. Unlike cycloheximide (CXM) which inhibits long-term memory by inhibiting ribosomal protein synthesis, AIB is non-effective when administered 10 min or more after learning, and its effect is overcome by the sodium pump stimulator diphenylhydantoin if the latter is administered 10 min or more after learning. Within the model of memory formation adopted in this paper it is postulated that the amino acids necessary for long-term memory protein synthesis are taken up by sodium pump activity in the first 10 min following learning, when formation of the preceding labile memory phase is occurring.

Amino Acids↗
PubMedDate not supplied

Statistical and methodological issues in the evaluation of case management studies.

For the past 3 years, the nursing case management team at North Shore University Hospital in Manhasset, NY, has been involved in a project to implement more than 50 clinical pathways, which provide a written "time line" for clinical events that should occur during a patient's hospital stay. A major objective of this project was to evaluate the efficacy of these pathways with respect to a number of important outcomes, such as length of stay, hospital costs, quality of patient care, and nursing and patient satisfaction. This article discusses several statistics-related issues in the design and evaluation of such case management studies. In particular, the role of a research approach in implementing and evaluating hospital programs, the choice of a comparison (control) group, the exclusion of selected patients from analysis, and the problems of equating pathways with diagnosis-related groups are addressed.

Case Management↗
PubMedDate not supplied

Diagnosis of renal malacoplakia by fine needle aspiration cytology. A case report.

BACKGROUND: Malacoplakia is a rare chronic inflammatory disease first described by von Hansemann in 1901. L. Michaelis and M. Gutmann published the first report in 1902, describing the characteristic round intracellular and extracellular inclusions, or Michaelis-Gutmann bodies. Renal malacoplakia is a form of chronic tubulointerstitial nephritis the clinical and radiologic findings of which are often suggestive of a neoplasm. Renal malacoplakia may be related to megalocytic interstitial nephritis and xanthogranulomatous pyelonephritis. CASE: A 67-year-old male presented with acute left loin pain suggestive of uretery colic. The past medical history was unremarkable and physical examination within normal limits. Renal ultrasound and computed tomography showed a 3.5-cm, cystic mass with a thickened, irregular wall located centrally within the left renal sinus. The size of the left kidney was 11.5 cm. A renal arteriogram provided no evidence of a vascular mass of any type. Fine needle aspiration (FNA) revealed many large, foamy, granular macrophages with large, eccentric nuclei and prominent nucleoli containing round inclusions that exhibited a laminated appearance, consistent with the structure of Michaelis-Gutmann bodies. Many were also present extracellularly. CONCLUSION: To our knowledge this is the first case of renal malacoplakia diagnosed by fine needle aspiration. This case demonstrates the value of FNA in determining the nature of a radiologically nonspecific lesion. It highlights the value of FNA as a substitute for or preliminary method before more invasive procedures in the diagnosis of a treatable disease entity.

Aged↗
PubMedDate not supplied

Men's health promotion in the UK: a hidden problem.

Health promotion services for men are often medically oriented or sporadic in nature. To meet men's health needs, issues of changing socioeconomic patterns and patriarchal dominance need to be addressed. An understanding of the basis for destructive male lifestyles, combined with innovative health promotion initiatives, must be implemented if men's health is to improve.

Health Promotion↗
PubMedDate not supplied

Glomerular disease made easier: 3.

In the concluding article in this series we describe those multisystem disorders that are characterised by significant renal involvement. As before, each will be considered under five headings: clinical presentation, aetiology, histology, treatment and prognosis.

Antibodies, Antineutrophil Cytoplasmic↗