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Biomedical subjects

S Rizzo

Publications and source records attributed to S Rizzo.

144 records · Page 8Linked to original sources
PubMedDate not supplied

[Cardiovascular and respiratory reflex responses due to stimulation of muscle nerve receptors and experimental physical exercise].

The cardiovascular and respiratory reflex effects brought on by the infection into the femoral artery of bradyquinine and of hypertonic sodium chloride solutions and by rhythmic muscular work and muscular work of tetanic type induced by low and high frequency electrostimulation in the muscles have been investigated in the rear extremity anaesthetized rabbits. Intra-arterial injection of bradyquinine and rhythmic muscular contractions trigger off cardiovascular reflux effects of inhibitory type represented by a reduction in arterial pressure, heart frequency and vascular resistances of the rear extremity controlateral to the one stimulated. Intra-arterial injection of hypertonic NaCl and tetanic contractions cause opposite effects, namely of decidedly excitatory type. Such responses are not substantially altered by complete removal of the skin layer of the stimulated extremity. The neuromuscular block obtained with curare-like substances does not affect chemical stimulation responses, whereas it eliminates similar effects caused by experimental muscular work. The experiments carried out show that injection into the muscular arteries of chemical agents of various type produces varying cardiovascular reflex effects as a result of activation of chemosensitive nervous receptors located in the muscular tissue, and also that during physical exercise similar reflex modifications are produced, very probably caused by stimulation of receptors present in the contracting muscles.

Animals↗
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Hyperthermia in the treatment of brain metastases from lung cancer. Experience on 17 cases.

Medium or long-term survival in metastatic "non oat cell" lung tumors is seldom possible only if surgery can eradicate the lesion. Out of 17 patients treated with hyperthermia plus nitrosoureas 16 (94%) responded, with clinical improvement, radiological regression or disease stabilization. The survival time of the improved patients was 12.7 months. Hyperthermia in combination with nitrosoureas seems to allow clinically and radiologically satisfactory responses in lung tumors metastatic to the brain.

Adult↗
PubMedDate not supplied

[Evoked otoacoustic emissions in noise-induced hearing loss].

The Authors evaluated patterns of click-evoked otoacoustic emissions (EOE) in a group of 184 patients exposed to noise in their working environment. The aim of the study was to detect changes in EOE patterns in this group compared to the EOE of healthy subjects. The clinical history of each subject was recorded and otoscopy, pure tone audiogram and impedance tests (tympanometry, stapedial reflex threshold) were carried out in all patients. Noise-induced hearing loss found in 97 patients, unilateral sensorineural hearing loss in 17, other hearing disorders in 24 and normal auditory threshold in 46. EOE recording was carried out in the group of patients with noise-induced hearing loss (97), in the group with normal threshold (46) and in a control group of 15 healthy subjects. EOE recording was obtained using the ILO 88 Otodynamic Analyzer. We introduce a probe into the external ear canal using a non-linear click stimulus (intensity at approximately 85 dB spl) at a 20/sec. rate with a 20 msec. window. Normal EOE were found in the control group. Abnormal EOE were found in 79 cases (81%) of the noise-induced hearing loss group, and in 22 (48%) of the normal threshold group. These data show that noise-exposed subjects have alterations of EOE such as threshold shift missing frequency bands, even in absence of an auditory threshold shift. When EOE were present, the frequency spectrum often showed lack of emissions at high frequencies. This study confirms that cochlear exposure to noise may produce significant alterations of EOE and that this test may be considered highly sensitive in detecting early cochlear damage in chronic acoustic trauma. Therefore, EOE may be used in screening and follow-up of high risk populations such as noise-exposed subjects.

Acoustic Impedance Tests↗
PubMedDate not supplied

[Pharyngeal cysts of branchial origin, a review of the literature and a clinical case report].

Nasal pharyngeal swellings are very often treated without a previous complete clinical examination of the patient and of the disease site. For this reason the recurrence rate of this pathology is quite high. The causes for this phenomenon are likely due to the benign aspect of the tumor and the easy approach to the pharynx. Leaving aside the therapeutical aspect, there are also multiple theories concerning the etiology of pharyngeal cyst based on epidemiological and histopathological observations. Branchiogenic origin very likely seems to be the cause of cystic swelling arising at the lateral side of the pharynx, between the Eustachian tube and the posterior tonsillar pillar. Examination of the case review collected from literature, revealed that diagnostic and therapeutical procedures performed by various authors seem to be very haphazard, ranging from simple physical examination and puncture draining to CT and/or MRI scanning and external trans-mandibular approach to the cyst. The authors describe one case of a subject with a pharyngeal branchial cyst, who had been previously undergone puncture drainage. The correct diagnosis was achieved through MRI and cytologic examination of the fluid aspirated from the cyst. With MRI it was possible to make a correct topo-diagnosis, which localized the position of the cyst in the left pharyngo-tonsillar recesses, medial to the pharyngeal constrictor muscles. MRI also confirmed the absence of fistulous ducts connected to the cyst. These clinical and laboratory data induced us to use an intra-oral approach to the cyst, which was removed by blunt dissection. Physical examination and MRI were repeated six months later and showed the complete removal of the cyst and the presence of a synechia between the upper part of the left posterior pillar and the pharyngeal wall. No further treatment was given because of the absence of symptoms. The authors stress the importance of less invasive surgery in the case of pharyngeal cyst possible after detailed monitoring of the disease site with modern computed tomography CT, MRI.

Adult↗
PubMedDate not supplied

Pulmonary sclerosing hemangioma in a woman with multiple uterine fibromas, cysts to thyroid and kidney.

Pulmonary sclerosing hemangioma (PSH) is a relatively rare, homogeneous solitary tumor. Its complex histology may suggest a number of malignancies. We report one case diagnosed in a 62-years-old woman with a tendency to benign tumors (uterine fibromas) and cystes (thyroide, kidney). Bronchoscopy was normal. Pulmonary scintiscan was not done. Chest X-ray showed a 2 x 2 cm solitary, dense, homogeneous, delimited nodule of the LLL. The intraoperatory diagnosis of adenocarcinoma led to lobectomy. The final diagnosis of PSH was done on fixed and stained samples. She is in good condition after 13 months of follow-up.

Adenocarcinoma↗
PubMedDate not supplied

Higher survival of refractory metastatizing breast cancer after thermotherapy and autologous specific antitumoral immunotherapy.

46 women (average 54.3 yrs) with refractory metastatizing breast cancer were treated with thermotherapy and autologous specific immunotherapy (rhIL-2 ex vivo activated cells). Metastases involved one organ in 69%; in particular, bone, lung, liver. The PS after treatment was satisfactory in 41%; the outcome was better in those cases with metastases to one site. The women remaining alive were 31/46; 67% of thermoimmunotherapy treated patients were alive after a maximum survival time of 85 months (median 24 months). The 36 months of control showed a 5-fold higher survival rate in our series when challenged with that of compared women undergoing only chemotherapy (p < .001).

Adult↗
PubMedDate not supplied

Pulmonary angiodysplasia: a case report.

A case of lung angiodysplasia is reported here in. The diagnosis of this disease before surgery is difficult. The intraoperatory diagnosis of vascular disease was possible since the pulsating mass disappeared after the inflow and outflow blood vessels were selectively clamped. The abnormal placement of a venous vessel made the resection problematical. A careful anatomic and clinical study of the lesion, and the correct instrumental diagnostic approach may lead to a suitable therapeutic stategy, which respects both functional integrity and surgical radicality. The usefulness of a systematical selective clamping of the inflow and outflow blood vessels for an exact delimitation of the lesion emphasised.

Angiodysplasia↗
PubMedDate not supplied

Survival of chemo-radiotherapy-treated and thermotherapy-treated patients with unresectable lung cancer.

Prognosis and survival of unresectable lung cancer patients is poor. The 5-year survival varies from 3 to 15% without relevant differences between treated and non-treated patients. The 2-year survival of comparable patients treated with chemo-radiotherapy (CH-RT) (n=63) and thermotherapy (RFT) (n=40) was studied. The 2-year follow-up survival curves did not differ for the groups in general but the survival time was longer for stage IV and non-small cell lung cancer in the RFT-group (13.2 mo and 13.4 mo, respectively) compared with CH-RT-group (8.4 mo and 9.6 mo, respectively). The difference was highly statistically significant (p<0.005).

Aged↗
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Long-term primary human tumor cell cultures and mixed autologous tumor-lymphocyte cultures for adoptive specific antitumoral immunotherapy.

Anticancer immunotherapy may improve the body's cancer defences, quality of life and survival. Encouraging treatment models have been proposed, namely the non-specific LAK and ALT cell therapies; the relatively specific TIL/CTL cell therapy as well as allogenic cancer vaccines; autologous cancer vaccines. A procedure to prepare an autologous antitumor serum for cancer therapy using ex vivo activated autologous cells is here reported. Peripheral blood lymphocytes obtained by leukaphoresis were cultured with autologous tumor cells in RPM1 1640 and rh-IL-2 for 48 hours at 37 degrees C in a humidified, CO2 enriched atmosphere. The cytokine rich supernatant, as well as the activated cells in medium were frozen, lysed and aliquotted, frozen, and stored at -20 degrees C. The material was used for specific anticancer immunotherapy. Fibroblast-free tumor cells are being maintained in long term culture for future ex vivo sensitization of autologous cells.

Cancer Vaccines↗
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Growth curves: a method of monitoring established long-term primary human tumor cell cultures for autologous immunotherapy.

Cytomorphologic methods evidentiate tumor cells (TC) and differentiate them from fibroblasts, but are not indicated f for long term cultures. Growth rate and curve shape of TC and autologous fibroblasts cultures were recorded and compared over 4 weeks. Both were morphologically documented ex vivo and after MGG stain. No fibroblast overgrowth was noted in the TC cultures. The cultures showed rather peculiar curves with little variability among TC cultures. The 1st-week rate was higher in the TC cultures (p < .01). Growth curve evaluation with ex vivo observation of the morphology is- an alternative method in monitoring TC cultures for autologous immunotherapy.

Ascites↗