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Biomedical subjects

S Richman

Publications and source records attributed to S Richman.

34 records · Page 2Linked to original sources
PubMed1978

Combination chemoimmunotherapy for extensive non-oat cell lung cancer.

In a prospective randomized trial, sc Corynebacterium parvum (C. parvum) immunotherapy did not significantly affect the responses and survival of 49 non-oat cell lung cancer patients receiving isophosphamide and adriamycin chemotherapy. Remissions (tumor regression greater than 50%) were seen in five of 23 patients receiving an intensive C. parvum schedule and in three of 26 patients receiving a nonintensive C. parvum schedule (22% versus 12%). Median survival was 20 weeks for patients given intensive C. parvum and 23 weeks for patients given nonintensive C. parvum. This study did demonstrate the importance of pretherapy immunocompetence, performance status, and weight loss as predictors for survival. Weight loss was the most significant prognostic factor. Performance status was closely associated with weight loss but skin reactivity to dermatophytin predicted independently and was the second most important prognostic characteristic.

Adenocarcinoma↗
PubMed1977

A statistical-heuristic methods for automated selection of drugs for screening.

A statistical-heuristic method for selecting drugs for animal screening is developed with molecular structure features as predictors of biological activity. The method is intended to work on large amounts of data over varied structures. A trial of this method on a small data set allows some comparison with more sophisticated pattern recognition methods. Problems connected with interdependence among structure predictors are critical in this method and schemes to eliminate redundancy are reviewed. Alternate sets of structure predictors are considered. The discussion here outlines directions to be taken in the near future.

Animals↗
PubMedDate not supplied

Medical school, psychosocial attitudes, and gender.

A scale measuring empathy and a scale measuring attitudes toward social issues and human relations in health care were administered to medical students when they were applicants to medical school and again midway through their third year. Students in their third year exhibited less positive and/or more negative attitudes compared to their scores as applicants. The changes were largest in areas relating to social issues, such as government involvement in health care, and least in areas relating to human relations, such as the role of social factors as determinants of a patient's health or illness. There were few differences between women and men on these scales. These data suggest that attitudes toward the interpersonal aspect of patient care may be less severely affected by the medical school experience than previously expected, and that the medical school experience does not affect women's attitudes differently than it does men's.

Attitude↗
PubMedDate not supplied

Initial clinical studies of vindesine.

Vindesine, a newer vinca alkaloid derivative, underwent a phase I clinical evaluation in 68 humans with advanced, refractory malignancies. Patients received single total doses ranging from 2 to 12.5 mg, repeated every 1-2 weeks. Dose-limiting myelosuppressive, gastrointestinal, and neurologic toxic effects were observed at higher doses. They consisted predominantly of neutropenia, constipation leading, on occasion, to paralytic ileus, and peripheral neuropathy. Total doses of 7.5-10 mg (equivalent to 4-5 mg/m2), repeated every 2 weeks, well-tolerated. There were two partial remissions in patients with acute leukemia and prior vincristine therapy, two minor responses in patients with renal cell carcinoma, one minor response in a patient with squamous cell carcinoma of the esophagus, and one minor response in a patient with squamous cell carcinoma of the lung. Vindesine is well-tolerated by man, although it shares some of the toxic manifestations of vinblastine and vincristine. Its efficacy in some patients who were no longer responsive to vincristine therapy suggests a lack of clinical cross-resistance between these compounds.

Adolescent↗