Biomedical subjects
S Resnick
Publications and source records attributed to S Resnick.
Letter: Familial canine diabetes mellitus.
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Effects of feeding a high-protein diet and an all-meat diet on the hemogram of the dog.
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Results of feeding high-carbohydrate and all-meat diets to pups at various ages.
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Effect of an all-meat diet and a high-carbohydrate diet on hip formation in dogs.
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Surgical removal of needle and thread from the throat of a dog.
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Hypocalcemia and tetany in the dog.
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Subcortical metabolic alterations in partial epilepsy.
The function of subcortical nuclei in partial epilepsy was investigated using positron emission tomography (PET) to measure metabolism in the basal ganglia and thalamus. Sixteen patients undergoing surgical evaluation were studied with 18F-fluorodeoxyglucose (FDG) interictally and had intensive extracranial and intracranial electrophysiologic evaluations. Eight patients had left temporal lobe seizure foci, six had right temporal lobe foci, and two had right posterotemporal or parietal foci. The PET data were analyzed visually and quantitatively, using a multivariate analysis of variance on the quantitative data. Hypometabolism of subcortical nuclei was present ipsilateral to the cortical seizure focus. Cortical hypometabolism was noted focally in the temporal lobe in patients with left temporal lobe seizure foci, whereas patients with right temporal lobe seizure foci had diffuse hemispheric hypometabolism. We postulate that the subcortical hypometabolism is secondary to decreased efferent activity from temporal lobe structures, in particular amygdala and hippocampus, to subcortical nuclei. Diminished subcortical activity may then lead to defective regulation of cortical excitability in the temporal lobe, increasing the likelihood of seizure development and spread.
Application of the thiocarbohydrazide-osmium coating technique to scanning electron microscopy of the inner ear.
The application of the thiocarbohydrazide-osmium coating technique to scanning electron microscopy of the inner ear is described. In this procedure specimens which have been prepared for electron microscopy (fixation in buffered glutaraldehyde or in Karnovsky's fixative followed by post fixation in osmium tetroxide) are twice exposed to solutions of thiocarbohydrazide and osmium tetroxide with water rinses in between each treatment. This method binds osmium to the specimen and so eliminates the need to coat the surface of the material with a layer of heavy metal. Initial observations indicate that this is a convenient and reliable method which is capable of yielding good results.