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Biomedical subjects

S Raz

Publications and source records attributed to S Raz.

203 records · Page 12Linked to original sources
PubMedDate not supplied

Direct positive inotropic effect of mannitol on the intact canine heart.

Infusion of 25% mannitol into either the circumflex or left anterior descending coronary artery caused a significant increase in myocardial force development, measured by means of strain gauge in 10 anesthetized dogs. The changes were confined to the area perfused. The increase in developed force was dose-dependent, 20% at an infusion rate of 0.55 ml/min, 28% at 1.4 ml/min, 32% at 2.8 ml/min and 57% at 5.5 ml/min. There was a similar increase in dF/dt. The increase in developed force in the first minute was also dose-dependent, being 9% at 0.55 ml/min and 40% at 5.5 ml/min. No change in developed force occurred in the control (non-perfused) area or during saline infusion of the same artery at similar rates. A decrease in developed force of 10.5% was observed after the initial rise when mannitol was infused at 5.5 ml/min. This effect did not completely abolish the initial increase. No change in blood pressure, heart rate, LV systolic and diastolic pressure of LV dp/dt occurred during the experiment. It is concluded that doses of mannitol which are in clinical use have a direct positive inotropic effect on the intact canine heart.

Animals↗
PubMedDate not supplied

T-2 toxin effect on isolated perfused rat hearts.

T-2 toxin is the major lethal component of several Fusarium fungi implicated in the disease of man and animals. We used isolated rats hearts to test the T-2 toxin cardiotoxicity. Electrodynamics and ultrastructural parameters were studied. The main changes consisted of decreased contractility and electrocardiographic abnormalities without much effect on heart rate or QRS and QT intervals. Ultrastructurally, swelling of myofibers and their mitochondria occurred and damage to the plasma membrane was seen. It is possible that the T-2 effect is mediated through soluble thiol to cause cytoplasmic calcium decrease and loss of plasma membrane integrity.

Animals↗
PubMedDate not supplied

Impression materials for removal of aural foreign bodies.

A new method for removal of aural foreign bodies is introduced, employing the injection of a semifluid impression material into the external auditory canal, and its removal after curing with the engulfed foreign matter. This technique obviated the need for a general anesthetic in some pediatric cases, while in others it was just a more pleasant experience.

Acrylic Resins↗