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Biomedical subjects

S Rasmussen

Publications and source records attributed to S Rasmussen.

At least 181 records · Page 10Linked to original sources
PubMed1984

Contrasting effects of the renin-angiotensin system on renal function disclosed during converting enzyme inhibition in patients with renal hypertension.

In three unilaterally nephrectomized patients with a poorly functioning remaining kidney, a reversible decrease of glomerular filtration rate (GFR) was observed during treatment with captopril. Only modest decreases in blood pressure occurred. In four patients with various forms of malignant hypertension and impairment of renal function, GFR remained unchanged or even increased when the blood pressure was reduced by captopril. All patients had increased plasma concentrations of renin and angiotensin II prior to captopril. We hypothesize that an activation of the renin-angiotensin system in hypertensive patients with reduced GFR may either reflect a compensatory mechanism aiming at maintaining renal function, or imply an excessive angiotensin-mediated vasoconstriction causing a decrease in renal function. The use of angiotensin converting enzyme inhibitors may be damaging for renal function in the first situation and beneficial in the second.

Adult↗
PubMed1984

Clinical echocardiography in acquired heart disease.

Echocardiography directly reflects cardiac anatomy and pathology. A normal two-dimensional and M-mode study rules out a multitude of cardiac pathologies. Echocardiography serves the clinician well in differentiating cardiac from noncardiac symptoms and in providing bedside quantitative assessment of regional and global left ventricular function. It is also invaluable in evaluating valvular disease, pericardial effusion, and intracardiac masses.

Aortic Valve Stenosis↗
PubMed1983

Haemodynamic and clinical effects of isosorbide-dinitrate in patients with severe effort angina on beta-blocking treatment.

The effect of isosorbide-dinitrate (ISDN) 20 mg 4 times daily against placebo has been tested in 12 patients with stable effort induced angina pectoris receiving prophylactic treatment with metoprolol. ISDN did not decrease the attack rate or nitroglycerine consumption, nor was exercise tolerance increased after it. Left ventricular function, assessed by radionuclide ventriculography, increased in 6 out of 8 patients (p less than 0.1). It is concluded that ISDN has no place in the treatment of haemodynamically intact patients with severe angina pectoris in spite of beta-blocking treatment, but that it may be of value in the treatment of patients with left ventricular failure, including those whose left ventricular failure has been brought about by beta-blocking treatment necessitated by angina pectoris.

Adult↗
PubMed1983

Purification and amino acid composition of type E botulinum neurotoxin.

The procedure we have adopted to purify type E botulinum neurotoxin (mol. wt. approximately 147,000) from bacterial cultures consistently yields a pure protein (a single band in polyacrylamide gel electrophoresis in the presence of sodium dodecylsulfate). Our procedure is a modification of one of the five published procedures. Other procedures have failed to yield pure neurotoxin. To develop reliable data on the amino acid composition, three batches of the neurotoxin were analyzed, each batch isolated from a separate neurotoxin producing culture. The best estimate of the number of amino acid residues per neurotoxin molecule was: Asp240 Thr75 Ser98 Glu118 Pro45 Gly58 Ala40 Val62 CyS7 Met17 Ile123 Leu107 Tyr70 Phe62 Lys97 His15 Arg34 Trp16.

Amino Acids↗
PubMed1983

Amino acid composition of Clostridium botulinum type F neurotoxin.

To develop reliable data on the amino acid composition of type F botulinum neurotoxin, three batches of the neurotoxin were analyzed. Each batch was isolated from a separate neurotoxin producing bacterial culture. Two batches had inoculum from one source and the other batch one from a different source. Two batches of the neurotoxin were purified by the same method and one was purified by a different method. The neurotoxin preparations were found comparable in purity and similar in amino acid composition. The best estimate of number of amino acid residues per neurotoxin molecule (mol. wt. 155,000) was: Asp218 Thr80 Ser105 Glu128 Pro47 Gly69 Ala47 Val72 CyS9 Met14 Ile128 Leu104 Tyr86 Phe60 Lys90 His13 Arg51 Trp23.

Amino Acids↗
PubMed1983

Effects of amiloride on plasma and total body potassium, blood pressure, and the renin-angiotensin-aldosterone system in thiazide-treated hypertensive patients.

Total body potassium content, plasma potassium concentration, blood pressure, and plasma concentrations of renin, angiotensin II, and aldosterone were measured in patients with essential hypertension after a run-in period of 8 wk on a regimen of hydrochlorothiazide (median dosage 75 mg/day). Patients were then randomly assigned to continued hydrochlorothiazide therapy (group I) or to receive adjunctive treatment with amiloride (group II, median dosage 15 mg/day or 5 mg per 25 mg hydrochlorothiazide) for the following 3 mo. There were no changes in group I patients during 3 mo on hydrochlorothiazide in plasma potassium, total body potassium content, or the renin-angiotensin-aldosterone system. Blood pressure was also unchanged. In group II patients addition of amiloride to hydrochlorothiazide induced a rise in plasma and total body potassium of approximately 15% and 4%. The potassium-retaining effect was maintained throughout the 12-wk period, although the maximal changes were observed after 8 wk of treatment. Supine blood pressure did not change, but there was a significant decrease in standing systolic blood pressure. There was a marked rise in plasma concentrations of renin, angiotensin II, and aldosterone.

Adult↗
PubMed1983

Generation and elimination of angiotensins I and II in the kidney, liver and lung.

Inflow and outflow concentrations of angiotensins I (AI) and II (AII) from both kidneys, the liver and the lung were measured in 30 hypertensive patients, the majority having lateralization of the renin secretion. In the renin secreting kidney the data indicated a high generation rate of AI. In the contralateral kidney and splanchnic region both AI and AII were 'eliminated', and in the lungs the results confirmed previous evidence of converting enzyme activity.

Adolescent↗
PubMed1983

Dexamethasone suppression test and TRH test in endogenous depression.

Dexamethasone suppression test (DST) and thyrotropin releasing hormone (TRH) stimulation test were performed in 34 patients with endogenous depression. Compared with 33 psychiatric controls (limit of discrimination for serum cortisol of 275 nmol/l = 10 micrograms/100 ml) the specificity of the DST was 91% and the sensitivity was 65%. Compared with 24 healthy subjects the sensitivity of the TRH test was 24%, and the combined sensitivity for the DST and the TRH test was 76%. In contrast to the TRH test the DST showed a significant relationship (r = 0.54, P less than 0.01) to the Hamilton Rating Score. Repeating the tests after clinical recovery parallel changes of the two tests were found in 14 of 19 patients with abnormal DST in the depressed phase. In the remaining five patients the DST normalized, while the TRH test remained unchanged. It is suggested that both the apparent higher diagnostic sensitivity and the higher rate of normalization after clinical recovery of the DST is due to the dependency of the severity of depression.

Adolescent↗
PubMed1983

Postpartum renal failure and malignant hypertension treated with captopril.

A case of postpartum renal failure and malignant hypertension in a 24-year-old woman is reported. The condition occurred three weeks after caesarian section following a normotensive pregnancy. Treatment with a converting enzyme inhibitor, captopril, for one year normalized the blood pressure, with concurrent reduction of plasma angiotension II concentration and markedly improved glomerular filtration rate. It is suggested that activation of the renin-angiotensin system may cause the hypertension and impairment of renal function in postpartum renal failure, and that use of drugs blocking the renin system may be of particular clinical value in this situation.

Acute Kidney Injury↗