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Biomedical subjects

S Rabinovich

Publications and source records attributed to S Rabinovich.

51 records · Page 3Linked to original sources
PubMed1972

Rimantadine therapy of influenza A infection in mice.

Eighty per cent of mice infected with a mouse-adapted strain of influenza virus died within 3 to 8 days after infection. Rimantadine given at maximum protective doses reduced mortality to 10%. This protection is dose related and can be demonstrated with doses from 4.5 to 24 mg per kg per day. Significant survival rates are shown by delaying treatment as long as 48 hr after infection. Lungs of treated mice have significantly less virus than those of controls at 24, 48, and 72 hr after infection. Antibody production as measured by hemagglutination inhibition is not different in treated and controlled mice. These results indicate that rimantadine is an effective prophylactic and therapeutic agent and that its activity is associated with decreased viral titers.

Animals↗
PubMed1971

Plasma calcitonin in renal osteodystrophy.

Whether calcitonin plays a significant role in the pathogenesis of renal osteodystrophy is not known. Plasma calcitonin-like activity (CLA) was measured by means of an extraction procedure and bioassay in 17 patients with chronic renal failure. Recent bone biopsy data were available for 11 patients. Plasma CLA was found to be in the normal range in the patients studied. There was a positive and strong correlation between plasma calcium and plasma CLA. Chronic dialysis and renal transplantation had no significant effect on plasma CLA. The severity and type of bone lesions did not correlate with plasma CLA. Although plasma calcitonin in chronic renal failure does not appear to be directly related to renal osteodystrophy, normal mobilization of calcitonin may protect the skeleton to some degree from the high levels of parathyroid hormone usually present in such patients.

Adult↗