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Biomedical subjects

S R Wray

Publications and source records attributed to S R Wray.

At least 37 records · Page 2Linked to original sources
PubMed1980

Bronchomotor tone in protein-energy malnutrition.

The study examined the reactivity of the tracheobronchial tree of rats maintained on low protein and tryptophan-deficient diets. It was found that: (1) Rats maintained on 5% protein or tryptophan-deficient diets showed little or no weight gain. A 15% protein diet was adequate for normal growth of female rats, but not of male rats. (2) Airways of malnourished rats showed significant bronchoconstriction when treated to an acetylcholine (AcCh) concentration of 10(-11) M. The threshold concentration of AcCh for normal rats was 10(-5) M. Airways of malnourished rats were also more sensitive to cold. (3) Rehabilitation of the malnourished rats attenuated the response to AcCh. Recovery, however, was not complete. (4) Prior application of phentolamine and atropine markedly reduced the sensitivity of the airways of malnourished rats to AcCh. The results seem to indicate that alpha-adrenoceptors and the vagus nerve may be involved in the observed increased reactivity of airways of malnourished rats.

Acetylcholine↗
PubMed1977

Differential attenuation by atropine and d-amphetamine on hyperactivity: possible clinical implications.

Intraperitoneal administration of physostigmine (0.025 to 0.18 mg/kg) to rats resulted in significant increases in motor activity as measured with jiggle platforms. Doses of physostigmine 0.2 mg/kg or more decreased motor activity. The physostigmine-induced hyperactivity was attenuated by atropine (5 mg/kg) given before or after physostigmine (0.05 mg/kg). On the contrary, d-amphetamine (2 mg/kg), given before or after, significantly potentiated the physostigmine-induced increase in motor activity. The relevance of the cholinergic system in mediating hyperactive behaviour in children is discussed.

Animals↗