Biomedical subjects
Publications and source records attributed to S R Porter.
The orofacial manifestations of 39 patients with primary IgA deficiency are reported. Aphthous-like oral ulceration was observed in 61% while candidosis and recurrent herpes labialis were each present in 25%. Only 4 (9%) patients had no orofacial lesions.
The orofacial manifestations of 15 patients with Common Variable Immunodeficiencies (CVID) are reported. Aphthous-like ulceration, pseudomembranous candidosis and/or enamel hypoplasia were observed in 11 patients. Four patients had no orofacial lesions.
The orofacial manifestations of 10 non-HIV-infected children with primary defects of cell mediated immunity are reported. Oral candidiasis was observed in 80% of patients, with oral ulceration present in 50%. Other oral manifestations included enamel hypoplasia, angular stomatitis, oral purpura and recurrent herpetic infection.
The orofacial manifestations of 17 children with primary defects of polymorphonuclear leukocyte function are reported. Oral disease was commonly found and included recurrent oral ulceration (35% of patient group), oral candidiasis (29%), recurrent herpes labialis (12%), enamel hypoplasia (18%) and delayed tooth eruption (12%). Only 3 children had no orofacial disease. Cervical lymph node enlargement was present in 41% of the children.
A wide spectrum of viruses can give rise to oral and periodontal manifestations. This article reviews viral infections of clinical importance to the periodontologist and confirms the important role of the periodontologist in the recognition and treatment of common viral infections of the mouth.
Tuberous sclerosis is a rare congenital disorder characterized by cutaneous angiofibromas, mental retardation, seizure disorders, and a variety of other, less common systemic anomalies. The present report details the features and periodontal management of a patient with gingival fibromata secondary to tuberous sclerosis.
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Dental hospital staff and students were observed during clinical work for their compliance with infection control procedures, as recommended by the British Dental Association. A total of 183 contacts between health care worker and patient were scrutinised during December 1990. Nearly all health care workers (96%) wore gloves to carry out dental treatment, but in some cases gloves were neither changed nor hands washed between patients. Only one half wore protective eyewear and about one third (38%) wore no mask. Some dental surgery assistants used heavy duty gloves and some even scrubbed dirty dental instruments without wearing any gloves. Strict audit is clearly needed in every clinical setting in order to ensure compliance with infection control.
This report describes a young male patient who had enamel hypoplasia, persistent oral candidiasis, skin hyperpigmentation, and vitiligo, and was thus suspected of having candidiasis endocrinopathy syndrome. The clinical and laboratory investigations employed to confirm the diagnosis are detailed.
White sponge nevus (WSN) is a benign hereditary lesion of the mucous membranes. DNA extracted from a biopsy specimen of oral WSN was assayed for the presence of DNA sequences homologous to human papillomavirus (HPV) types 1, 2, 4, 6, 11, 13, 16, and 18 by Southern blot hybridization. Only HPV-16 homologous DNA sequences were detected at a copy number of approximately 200 to 250 genome copies per diploid cell. The viral DNA sequences did not appear to be integrated into the host cell chromosome. The finding of HPV-16 in an inherited lesion such as WSN indicates that caution must be exercised in ascribing a causal association in relation to the demonstration of HPV in other mucosal disorders.
A case of desquamative gingivitis caused by adult linear IgA disease is presented. Management initially proved to be difficult, however, the introduction of sulfapyridine caused rapid resolution of the gingival problem. This is one of the first reports of desquamative gingivitis caused by linear IgA disease successfully treated with sulfapyridine.
Serum levels of immunoglobulin G (IgG) subclasses were examined in 71 adult patients with minor recurrent aphthous stomatitis (MiRAS). Seven patients (10%) had altered IgG subclasses: six had marginally raised IgG1 levels and one had a low level of IgG3. It is concluded that abnormalities of IgG subclass levels do not underlie MiRAS.
After a decade of study of the acquired immunodeficiency syndrome (AIDS) there is evidence to address the concerns of dental staff about possible transmission of human immunodeficiency virus (HIV). This paper reviews that evidence which demonstrates an extremely low risk of transmission of HIV to staff and patients. Only a few isolated cases have implicated transmission during dental practice, however, there are no proven cases where seroconversion has been demonstrated in relation to an exposure during dental treatment.
The recent identification of one of the causes of non-A, non-B hepatitis (NANBH) has led to an improved understanding of the epidemiology and possible clinical manifestations of this infectious disorder. NANBH is of some concern to dental personnel since the causative agents may be transmitted to health care workers and there is no effective immunization against NANBH. Current recommendations for cross infection control in the dental workplace must apply to NANBH.
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Explore the source record for details and available documents.
Explore the source record for details and available documents.