Biomedical subjects
Publications and source records attributed to S R Moore.
The United States undertakes the development of health objectives for 10-year cycles, covering the full range of federal health care delivery and policy. The goals for the cycle ending in the year 2000 have recently been announced.
A case of severe external root resorption in several teeth caused by unerupted permanent teeth is presented along with the initial surgical treatment.
Explore the source record for details and available documents.
One researcher has noted that forced inactivity leads to changes that are similar to those associated with the aging process, possibly indicating that some of the effects of aging may be due to inactivity rather than an intrinsic biologic process. The benefits of regular physical activity include improved cardiopulmonary function, lowered blood pressure, increased bone mineral content, increased muscle strength and joint flexibility, and improved psychological well-being. Walking is an excellent activity for seniors because it is a low impact sport, making the potential for injury low. A multi-faceted walking program managed by nurses can provide health promotion activities such as screenings, educational programs, weight-reduction classes, and health consultation. The sponsoring hospital, mall, and most importantly the walkers benefit from participation in such a program.
Explore the source record for details and available documents.
By law, the commissioner of the Food and Drug Administration (FDA) is responsible for determining whether a new drug is safe and efficacious before it is approved for marketing in the U.S. and for monitoring its use after approval. This paper provides a brief overview of the approval process, in terms of responsibilities of the sponsor in submitting an application for review to the FDA and FDA's responsibilities and organizational procedures for reviewing and approving those applications. A brief history on the legislation regarding the FDA's responsibility in the drug approval area is discussed along with recent regulations, legislation, and FDA initiatives aimed at improving the drug approval process. Specific information that can be released to the public upon request is also discussed. This paper is limited to the regulation of drugs; somewhat different regulations govern the review and regulation of biological products and abbreviated new drug applications.
Explore the source record for details and available documents.
Peripheral blood polymorphonuclear leucocytes (PMNs) were isolated from six normal individuals and from 27 patients with rheumatoid arthritis (RA) by the Ficoll-Hypaque rapid single step centrifugation technique, fixed in suspension, and examined by scanning electron microscopy (SEM). In addition, four of the preparations from normal individuals and eight from patients with RA were examined by transmission electron microscopy (TEM). Most PMNs in preparations from normal subjects were spherical, unpolarised, and had their surface membrane elaborated into irregular ridges and small ruffles; they contained few phagocytic vacuoles and large numbers of electron dense primary and secondary granules. A minority of the cells were non-spherical, polarised, and had portions of their surface membrane elaborated into ruffled pseudopodia. In contrast, preparations of RA PMNs frequently contained fewer unpolarised PMNs and a higher number of polarised PMNs than did preparations of normal PMNs. Some preparations of RA PMNs also contained substantial numbers of spherical cells whose surface was covered mainly by bulges and blebs. Concurrent examination by TEM showed that RA PMNs frequently contained more phagocytic vacuoles and fewer electron dense primary and secondary granules than normal PMNs. The morphological and ultrastructural changes seen in RA PMNs resembled those which normal PMNs are known to undergo on exposure to C5a in vitro, during adherence to endothelial cells in vivo, or during phagocytosis in vivo or in vitro. Our observations, therefore, provide a useful morphological correlation to those in vitro studies in which differences in the functional activity of RA and normal PMNs have been shown. The possibility that the difference seen between RA and normal PMNs is artefactual and does not represent the genuine in vivo states of these cells is discussed.
Explore the source record for details and available documents.
IgG aggregates produced by heating gamma globulin solutions were freeze-dried, kept at 4 degrees C and reconstituted up to 4 months later. By comparison with frozen (-20 degrees C) preparations, only minimal changes in biological reactivity and in physical integrity occurred during this period. These results demonstrate that freeze-dried preparations of heat-aggregated IgG are potentially useful as a reference reagent for the comparative evaluation and standardisation of immune complex assays.
A modification of the glutaraldehyde-osmium tetroxide-tannic acid-uranyl acetate (GOTU) fixation procedure is described which allows human leucocytes to be examined subsequently by either transmission electron microscopy (TEM) or scanning electron microscopy (SEM).
Attempts to use the rapid single-step Ficoll-Hypaque centrifugation procedure for the purification of mononuclear and polymorphonuclear leucocytes from the blood of normal individuals and rheumatoid arthritis patients have sometimes been unsuccessful, largely because the erythrocytes would not sediment through the centrifugation medium. Re-evaluation of the factors (e.g. Ficoll concentration, temperature, and ratio of the diatrizoate salts) which affect these separations showed that under our conditions it was advantageous to use a medium with a lower viscosity (Ficoll concentration) and/or a higher osmotic strength (increased sodium diatrizoate: meglumine diatrizoate) than had been recommended previously (Ferrante and Thong, 1978; 1980; Ferrante et al., 1982). Higher osmotic strength media must be used for separating the components of blood from rheumatoid arthritis patients than from normal individuals because rheumatoid arthritis erythrocytes have a lower buoyant density than normal erythrocytes.
Explore the source record for details and available documents.
The elderly population continues to be a major consumer of drugs. In working with this population, special consideration should be given to the specific problems that make drug use in the elderly more complex. One area that is often not considered is cognitive aspects of information receipt, storage, retrieval, and utilization. By considering these factors in working with the elderly, more appropriate and useful outcomes may be achieved.
Analysis of responses of 267 elderly subjects to a telephone survey dealing with communications between patients and health professionals about prescribed medications indicated several age-related differences. Results showed that elderly patients received less general information and less drug-specific information than younger patients did. This occurred in both pharmacist and physician encounters.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.