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Biomedical subjects

S R Gould

Publications and source records attributed to S R Gould.

36 records · Page 2Linked to original sources
PubMed1985

Coexistent ulcerative colitis and Crohn's disease.

This case report describes a patient with chronic ulcerative colitis and epithelial dysplasia of 17 y duration ultimately complicated by colonic carcinoma. At laparotomy, clinically unsuspected but typical Crohn's disease of the terminal ileum was also found. The macroscopic and histological features of the resected terminal ileum were characteristic of Crohn's disease.

Adenocarcinoma, Mucinous↗
PubMed1982

Castor oil or senna preparation before colonoscopy for inactive chronic ulcerative colitis.

Few clinically apparent clinical relapses of colitis occurred in 340 patients with previously extensive ulcerative colitis in an inactive phase submitted to total colonoscopy for dysplasia screening after bowel preparation with castor oil or senna. A prospective trial in 46 such patients showed both preparations to be equally safe and effective. Minor untreated disturbances of bowel habit occurred in 14 patients (30%), and three patients (7%) required a short period of oral corticosteroids. No patient with inactive colitis in either the retrospective series or the trial group had a serious exacerbation of colitis as a result of the bowel preparation, which was considered necessary and clinically justified for the purposes of cancer screening.

Adult↗
PubMed1981

Studies of prostaglandins and sulphasalazine in ulcerative colitis.

Specific evidence is presented of the release of prostaglandins from the colon in active ulcerative colitis. An increase in the levels of bioassayed prostaglandin-like activity in the stools and colo-rectal venous plasma from patients with active ulcerative colitis is described. Radioimmunoassay confirms the presence of prostaglandin E and prostaglandin F in the stools in colitis. Increased urinary levels of prostaglandin F metabolite occur in patients with active colitis and return to normal as the disease becomes quiescent. Sulphasalazine and its faecal metabolite, 5-aminosalicylic acid, were shown by an indirect method (reduction of the tone of the isolated rat fundus strip) to inhibit prostaglandin biosynthesis in vitro. In contrast, sulphasalazine was without effect on the urinary excretion of prostaglandin F metabolite in 7 healthy subjects. In 2 patients with colitis withdrawal of sulphasalazine was associated with increasing levels of stool prostaglandin-like activity and urinary prostaglandin F metabolite excretion. Indomethacin, given to 3 patients with chronically active ulcerative colitis, unresponsive to standard medical treatment, was associated with a decreased urinary excretion of prostaglandin F metabolite but was without clinical benefit. The possible mode of action of sulphasalazine as a prostaglandin inhibitor in colitis is discussed along with the potential use of other prostaglandin inhibitors.

Adolescent↗
PubMed1978

Controlled trial of disodium cromoglycate in chronic persistent ulcerative colitis.

Oral disodium cromoglycate (200 mg qds) has been tested in 26 patients with ulcerative colitis that was resistant to medical treatment. In a double-blind crossover trial disodium cromoglycate and placebo were added to conventional treatment in random order, each for four weeks. There was no significant difference in therapeutic effect between disodium cromoglycate and placebo.

Adolescent↗
PubMed1977

Barium meal appearance simulating superficial ulceration.

Five cases of diffuse gastric spiculation seen on single contrast barium meal examination are reported. This appearance may spuriously suggest superficial mucosal ulceration in cases in which no evidence of this is found endoscopically or histologically. This radiological appearance may be due to filling of the grooves between the areae gastricae and may thus represent a normal anatomical variant.

Adult↗
PubMed1976

Assay of prostaglandin-like substances in faeces and their measurement in ulcerative colitis.

A method is described for extracting and measuring prostaglandin-like substances from faeces. Bioassay has shown virtual absence of activity in stools from normal people (8 subjects) but raised levels in stools from patients with active ulcerative colitis (16 observations on 6 patients). The relevance of these observations to the mode of action of sulphasalazine is discussed and suggestions for possible applications of this method to other problems made.

Acute Disease↗
PubMed1976

Incidence of deep vein thrombosis and leg oedema in patients with strokes.

In a series of 26 patients with strokes 13 had deep vein thrombosis (DVT) in the leg, demonstrated by fibrinogen scanning. In 10 patients the thrombosis was in the paralysed leg but the degree of paralysis was unrelated to the tendency to develop DVT, which usually occurred about the third day. Leg oedema in 10 patients was unrelated to the DVT.

Cerebrovascular Disorders↗