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Biomedical subjects

S R Gambino

Publications and source records attributed to S R Gambino.

At least 19 recordsLinked to original sources

The autopsy. The ultimate audit.

Four hundred twenty-eight autopsy cases were reviewed at a departmental conference over a 4 1/2-year period. All diagnostic test data were discussed before the results of the autopsies were known, and the participants tried to extract the maximum diagnostic information from the clinical findings and the test data. Fifty-two percent of the autopsy cases failed to provide any additional major insight; premortem clinical and laboratory findings were sufficient for diagnosis. In the remaining 48%, however, the autopsies contributed to the improvement of medical care.

Autopsy↗

Direct current cardioversion. Effect on creatine kinase, lactic dehydrogenase and myocardial isoenzymes.

Creatine kinase (CK), lactic dehydrogenase (LDH), and more recently their isoenzyme determinations (CK-MB and LDH1) have been useful adjuncts in verification of myocardial injury. To determine whether DC cardioversion affects these serum enzyme levels, we recorded total CK, total LDH, CK-MB, and LDH1 levels serially during 24 hours following elective DC cardioversion in 18 patients without cardiac ischemia. New postcardioversion elevations in total CK and total LDH levels were small and occasional: CK (one of 18 patients), LDH (four of 18 patients). Elevations of CK-MB or LDH1 following cardioversion did not develop in any of the patients. Therefore, new CK-MB or LDH1 elevations associated with arrhythmias must result from myocardial damage to DC cardioversion.

Acute Disease↗