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Biomedical subjects

S R Gambert

Publications and source records attributed to S R Gambert.

86 records · Page 5Linked to original sources
PubMed1981

Interaction of age and thyroid hormone status on Na+-K+ ATPase in rat renal cortex and liver.

Na+-K+ ATPase was measured in euthyroid, hypothyroid, and hyperthyroid rats aged 6 weeks, 6 months, and 20-24 months. There was a small but significant decline in basal enzyme activity with increasing age in renal cortical tissue. Enzyme activity decreased with hypothyroidism and increased with hyperthyroidism. With increasing age, both the magnitude of the increase resulting from thyrotoxicosis and the absolute enzyme level were significantly less with each increase in the age of the experimental animals. Hypothyroid animals displayed no age-related decline in renal cortical Na+-K+ ATPase. The decline in Na+-K+ ATPase in renal cortical tissue is thyroid hormone dependent. In addition, age modifies the response of Na+-K+ ATPase to thyroid hormone.

Aging↗
PubMed1981

Running elevates plasma beta-endorphin immunoreactivity and ACTH in untrained human subjects.

Twenty minutes of submaximal treadmill running was associated with an elevation in plasma levels of beta-endorphin immunoreactivity (P less than 0.02). This increase was greater in men (14.9 +/- 3.4 fmole/ml) than women (2.6 +/- 1.2 fmole/ml)(P less than 0.05). Plasma levels of ACTH and growth hormone also increased after running. ACTH increased more in men (7.8 +/- 1.1 fmole/ml) than in women (1.1 +/-0.44 fmole/ml)(P less than 0.02). There was a similar growth hormone response in both sexes. No correlation can at this time be made with levels in the central nervous system. Changes in plasma levels of beta-endorphin immunoreactivity may be responsible for some of the euphoria and analgesia anecdotally associated with running.

Adrenocorticotropic Hormone↗
PubMed1980

Fasting associated with decrease in hypothalamic beta-endorphin.

In rats that were fasted for 2 to 3 days there was a decline in hypothalamic, but not pituitary, beta-endorphin. There was no change in pituitary or hypothalamic adrenocorticotropin content as a result of fasting. Endogenous opiates may be involved in physiological adaptation to fasting.

Adrenocorticotropic Hormone↗
PubMed1980

Protein-calorie malnutrition in the elderly.

Protein-calorie malnutrition, common among the elderly, often escapes recognition. This article reviews some of the etiologic factors and the clinical manifestations. Ways to assess and prevent protein-calorie malnutrition are also discussed.

Aged↗
PubMed1980

Thyroid status and the depressed elderly.

Although many studies have been devoted to linking thyroid status and depression, the results have been conflicting. This review concerns types of depression and suggests a paradigm that could encompass the role of the thyroid in aging and depression. Also discussed are thyroid function and its modification in the treatment of depression. Special precautions should be taken with the use of tricyclic antidepressants and with the enhanced cardiotoxic effects when combined with certain thyroid factors in the treatment of depression alone in the elderly.

Aged↗
PubMed1980

Age-related changes in central nervous system beta-endorphin and ACTH.

Aging is associated with alterations in mood, thermoregulation, pain threshold, and stress response. Because these functions may be modulated by endogenous opiates, we measured immunoreactive ACTH with beta-endorphin in discrete brain areas and pituitary glands from rats aged 6 weeks (young), 6 months (mature), and 20-24 months (senscent). Beta-Endorphin and ACTH declined significantly with aging in the hypothalamus and corpus striatum. Beta-Endorphin and ACTH increased in the frontal lobe during early life; however, no change was noted after maturity. A discordant response with age was noted in the pituitary in that (ACTH did not change, while beta-endorphin increased early in life without change after maturity. Cerebellar tissue exhibited no immunoreactive ACTH or beta-endorphin. Age-related changes in brain and pituitary beta-endorphin and ACTH must be considered in the evaluation of the physiological aging process and when comparing studies of these neuropeptides.

Adrenocorticotropic Hormone↗
PubMedDate not supplied

Aging--an overview.

Explore the source record for details and available documents.

Aged↗
PubMedDate not supplied

Assessing thyroid function in the elderly.

Problems in thyroid function are commonly encountered in caring for the elderly patient. Due to difficulties in clinically assessing thyroid status, thyroid function tests become increasingly important. Many problems exist in terms of interpretation of these tests due to physiological alterations accompanying aging and interactions with medications often taken by the elderly. This article discusses aspects of thyroid hormone economy, clinical presentation of disorders of the thyroid gland and offers advice to avoid pitfalls in diagnosing thyroid problems in the elderly.

Aged↗