Search PubMed⌕ Search

Biomedical subjects

S R Freidberg

Publications and source records attributed to S R Freidberg.

At least 37 records · Page 2Linked to original sources
PubMed1985

Ataxic Creutzfeldt-Jakob disease: diagnostic techniques and neuropathologic observations in early disease.

We studied two cases of ataxic Creutzfeldt-Jakob disease. EEG, CT, evoked responses, and CSF were normal in one purely ataxic patient. Diagnosis was established by cerebellar biopsy. Autopsy demonstrated devastating spongiform changes in the cerebellum, basal ganglia, and thalamus with rare focal changes in cerebral cortex. In the second patient, late generalized changes developed with dementia. Diagnostic studies included abnormal visual evoked responses, CSF with abnormal oligoclonal bands and IgG, and subacute spongiform encephalopathy in frontal lobe biopsy. Early diagnosis is best established by biopsy of brain areas most likely to be involved on the basis of clinical neurologic findings.

Ataxia↗
PubMed1984

Primary intrasellar germinoma in a woman presenting with secondary amenorrhea and hyperprolactinemia.

A 32-year-old woman with secondary amenorrhea was found to have an elevated level of serum prolactin, partial diabetes insipidus, and a subtle visual field defect. A primary intrasellar tumor was noted on the computed tomographic scan. Although the tumor had some characteristics of a prolactinoma, transsphenoidal exploration revealed a primary germinoma. The tissue diagnosis led to appropriate treatment with radiotherapy. The tumor regressed, and the patient had a spontaneous pregnancy. Had dopamine agonists been used initially, amelioration of the hyperprolactinemia and delay in the proper diagnosis and treatment would have occurred.

Adult↗
PubMed1982

Primary cerebellopontine progressive multifocal leukoencephalopathy diagnosed premortem by cerebellar biopsy.

A subacute progressive cerebellar brainstem syndrome developed in a patient with systemic lupus erythematosus in remission. Cerebellar biopsy documented the diagnosis of progressive multifocal leukoencephalopathy (PML). Data from this patient and 10 others in the literature emphasize the need to consider this diagnosis when ataxia develops in any patient with underlying malignancy, chronic infection, or other disease that involves immunological incompetence. Although the ataxic form of PML is not of nosological relevance, early diagnosis may eventually have therapeutic importance.

Biopsy↗
PubMed1982

Concurrent production of adrenocorticotropin and prolactin from two distinct cell lines in a single pituitary adenoma: a detailed immunohistochemical analysis.

A pituitary tumor from a patient with severe Cushing's disease and marked hyperprolactinemia was extensively studied by immunohistochemical techniques. Tissues from two separate areas of the adenoma were found to contain similar cell proportions of PRL as well as ACTH and related peptides (beta-lipotropin, beta-endorphin, and alpha MSH). The tumor was composed of approximately 70% immunoreactive PRL cells and 5% ACTH-containing cells. Double immunostaining revealed that PRL or ACTH and related peptides were found in two distinct populations of tumor cells. These results document for the first time inappropriate synthesis and secretion of an unusual combination of pituitary hormones from a mixed pituitary adenoma.

Adenoma↗
PubMed1980

Combined otolarygologic and neurosurgical approaches to tumors of the temporal bone and skull base.

Craniofacial resections are extensive procedures with serious potential complications and may not lead to cure but appear to offer an appreciable palliative benefit. This is acceptable for situations normally considered inevitably fatal. Most neoplasms of the head and neck are relatively slow growing and metastasize to distant sites late in their course. This can lead to months or years of suffering. Eliminating a bulky, unsightly, painful neoplasm can make remaining life more tolerable. Further, if cure is to be at all possible, an attempt must be made at total excision. In the recent experience of the Lahey Clinic with five patients utilizing a combined approach, results have been gratifying for both patients and surgeons.

Ear Neoplasms↗
PubMed1979

Treatment of intracranial hemorrhage.

The acute cerebellar hematoma and the subdural hematoma resent urgent surgical problems and treatment early in the clinical course should result in an excellent outcome. The subdural hematoma may be especially difficult to diagnose early, but may be suspected in patients on anticoagulant therapy or with shunze, and surgery, especially in the acute stage, should be avoided if possible. The CT scan supplemented when necessary by angiography is the diagnostic procedure of choice and will clearly demonstrate the lesions.

Anticoagulants↗
PubMed1979

Intranasal approach to the sella turcica.

A transseptal approach to the sella turcica is described which is entirely intranasal and avoids the sublabial incision. The first incision is unilateral along the caudal edge of the septum, and the second incision is made across the base of the nasal columella. This allows the speculum to open the width of both nasal chambers, giving adequate exposure. The septal cartilage is either preserved or resected except for a caudal strut. The difficult dissection of mucosa from the nasal floor and maxillary crest is avoided. This technique is rapid and straightforward and results in a cosmetically acceptable scar.

Humans↗
PubMed1976

Amyloidoma of the gasserian ganglion.

A case report, the third in the literature, is presented of a patient whose progressive numbness in the second and third divisions of the trigeminal nerve led to the discovery of an isolated amyloidoma of the gasserian ganglion. The clinical impression of tumor was confirmed by surgical and pathologic findings.

Amyloidosis↗
PubMed1975

Neurosurgical treatment of pain caused by cancer.

While pain can be a most useful symptom, it becomes a problem requiring attention when it causes or increases the patient's anxiety, prevents sleep, or starts the patient on a vicious cycle of increasing doses of narcotics with concomitant depression, anorexia, and lethargy. Various surgical modalities and their indications are discussed.

Bone Neoplasms↗