Search PubMed⌕ Search

Biomedical subjects

S R Deans

Publications and source records attributed to S R Deans.

3 recordsLinked to original sources

On the statistical nature of mammograms.

We show that digitized mammograms can be considered as evolving from a simple process. A given image results from passing a random input field through a linear filtering operation, where the filter transfer function has a self-similar characteristic. By estimating the functional form of the filter and solving the corresponding filtering equation, the analysis shows that the input field gray value distribution and spectral content can be approximated with parametric methods. The work gives a simple explanation for the variegated image appearance and multimodal character of the gray value distribution common to mammograms. Using the image analysis as a guide, a simulated mammogram is generated that has many statistical characteristics of real mammograms. Additional benefits may follow from understanding the functional form of the filter in conjunction with the input field characteristics that include the approximate parametric description of mammograms, showing the distinction between homogeneously dense and nondense images, and the development of mass analysis methods.

Breast Neoplasms↗

Multiresolution statistical analysis of high-resolution digital mammograms.

A multiresolution statistical method for identifying clinically normal tissue in digitized mammograms is used to construct an algorithm for separating normal regions from potentially abnormal regions; that is, small regions that may contain isolated calcifications. This is the initial phase of the development of a general method for the automatic recognition of normal mammograms. The first step is to decompose the image with a wavelet expansion that yields a sum of independent images, each containing different levels of image detail. When calcifications are present, there is strong empirical evidence that only some of the image components are necessary for the purpose of detecting a deviation from normal. The underlying statistic for each of the selected expansion components can be modeled with a simple parametric probability distribution function. This function serves as an instrument for the development of a statistical test that allows for the recognition of normal tissue regions. The distribution function depends on only one parameter, and this parameter itself has an underlying statistical distribution. The values of this parameter define a summary statistic that can be used to set detection error rates. Once the summary statistic is determined, spatial filters that are matched to resolution are applied independently to each selected expansion image. Regions of the image that correlate with the normal statistical model are discarded and regions in disagreement (suspicious areas) are flagged. These results are combined to produce a detection output image consisting only of suspicious areas. This type of detection output is amenable to further processing that may ultimately lead to a fully automated algorithm for the identification of normal mammograms.

Algorithms↗