Second revision of mortality prevention potential of conservative neonatal care.
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Biomedical subjects
Publications and source records attributed to S R Daga.
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We performed a randomized controlled study of the mortality and morbidity of 49 babies born with thick meconium staining of amniotic fluid. These unasphyxiated babies were consecutively born and were admitted to the intensive care unit for observation as routine. The groups were comparable in regard to sex, birth weight, gestational age, maternal factors like anaemia, toxaemia, antepartum haemorrhage, prolonged rupture of membranes, presentation, and interventions including caesarian section. The control group, comprising 26 babies received only oropharyngeal suction, while the intervention group, comprising 23 babies, underwent oropharyngeal suction followed by tracheal suction. There was no significant difference in the mortality or morbidity in form of evidence of air leak or hypoxic ischaemic encephalopathy.
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This study was carried out in a tribal block in Maharashtra in 1987. Socio-economic and obstetric factors commonly known to be associated with unfavourable perinatal outcome were assessed by studying odds ratio, attributable risk, and stepwise multiple regression. Preference for traditional health care, long distance from health post, teenage pregnancy, inadequate schooling, hard physical work, first or fifth and subsequent pregnancy, certain antenatal, intranatal, and postnatal factors emerged as important causes associated with perinatal loss.
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The Rural Neonatal Care Project, started by the Government of Maharashtra in the Ganjad Primary Health Centre, Dahanu block in Maharashtra, had the TBA as the sheet anchor for delivery of neonatal care. Maintenance of "warm chain" and resuscitation of an asphyxiated baby were recognized as the most important interventions besides detection of a very low birth weight/preterm baby and safe transportation of such a baby. Foot length measurement from foot print was used as a surrogate to birth weight as an indicator for referral. Neonatal and perinatal mortality rates dropped appreciably over 3 years and the antenatal registration went up by 30%. The cost of this programme is affordable and the programme itself was acceptable to the community and the TBAs because of its simplicity.
Determinants of death in newborns admitted to the Intensive Care Unit were studied taking into consideration antenatal history, intrapartum events, and clinical findings. Over 3 years (1984, 1985 and 1986) 1747 admissions were the subjects of this study. Of these, 424 deaths formed the study group and 1323 survivors form the control group. Odds ratio, attributable risk, univariate analysis, multiple stepwise regression, and analysis of variance were obtained. Clinical features associated with respiratory distress, birth asphyxia, admission to nursery after 6 hours of birth, and hypothermia on admission were found to be important factors related to death among nursery admissions.
Quantity as well as quality of survivals determine the performance of a neonatal centre. Our centre has succeeded in improving survival with low cost technology without compromising the quality. Neurodevelopmental handicap was low on a 1-year follow-up. No baby had retinopathy of prematurity or hearing deficit. Dropout rate has been high although comprising of mainly full-term or near-term babies with mild perinatal asphyxia or mild respiratory distress or requiring instrumentation during delivery. Longer follow-up is desirable.
In this retrospective analysis, 56 babies with Apgar score 3 and less were studied. In 33, successful bag-mask ventilation was carried out. Seventeen babies received endotracheal IPPV. In 9 out of them bag-mask ventilation was never tried whereas in 8 bag-mask ventilation had failed. In 6 babies physical stimulation and blast of oxygen on the face was adequate. Following this experience, in the subsequent years, endotracheal intubation was required mainly in extremely low birth weight babies or babies with Apgar score 0 at birth. During the study period, drugs were used in about 50% babies. In subsequent years this figure has come down to 10%, that too in special situations. This study helped us to evolve a policy in resuscitations severely asphyxiated babies. Bag-mask ventilation is the first choice. Failure to achieve progressively improving Apgar score by 1 minute, usually 4-5, is an indication for endotracheal intubation. Drugs are required in special situations only.
In developing countries the need for a risk approach in neonatology is obvious because of a high birth rate, high neonatal mortality rate, and limited availability of resources. Quantification of risk, with selected antepartum, intrapartum factors, clinical, and post-mortem findings was done by calculating odds ratio, attributable risk, and 95 per cent confidence limits in 1811 babies, 541 of which were asphyxiated. Primigravidity, history of perinatal death, pregnancy induced hypertension, and antepartum haemorrhage carried higher risk. Abnormal fetal heart rate and meconium passage in amniotic fluid correctly predicted high risk of birth asphyxia. Decreasing risk in premature/low birth weight babies without increase in abdominal deliveries suggested that caesarean sections were unnecessary in preterm deliveries. Clinical monitoring of asphyxiated newborns was adequate enough.
A baseline health survey was carried out in tribal area of Dahanu taluka in Maharashtra as a part of Rural Neonatal Care Project of the Government of Maharashtra. A population of 9684 was surveyed following the technique of cluster-sampling. High perinatal, neonatal, and maternal mortality rates were noted. Unfavourable maternal characteristics, obstetric factors, and infrastructural facilities contributed to high mortality rates.
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