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Biomedical subjects

S Qureshi

Publications and source records attributed to S Qureshi.

106 records · Page 6Linked to original sources
PubMed1977

Depression following myocardial infarction: the effects of distance running.

A proportion of postcoronary patients seen 16 to 18 months after infarction are seriously depressed (high D score on Minnesota Multiphasic Personality Inventory). A follow-up of 44 such depressed patients showed a significant (p less than 0.001) decrease of standardized D scores, from 80 to 72 units over 4 years of exercise-based rehabilitation. There were associated decreases in scores for hysteria, hypochondriasis, and psychasthenia. A decrease of D score was associated with exercise compliance. An increase of D score was associated with a significant (p less than 0.05) worsening of ST segmental sagging, suggesting that progression of the disease process had contributed to the increase of depression. All of the patients had high (feminine) scores on the masculinity/femininity scale of the MMPI test. This finding was unrelated to the daily running distance or medication; it could represent a "feminine" personality, or be a typical response in a well-educated white collar group. Evidence of successful group interaction may be indicated by reduction in scores for social introversion and schizophrenic traits.

Adult↗
PubMed1977

A study of swine dysentery by immunofluorescence and histology.

Twenty-six specific-pathogen-free pigs were fed pure cultures of Treponema hyodysenteriae. Five untreated pigs were controls. Distribution of this large spirochete in pigs with swine dysentery was shown by the indirect fluorescent antibody technique. Findings by this method were compared with those from dark-field examination of colonic mucosal scrapings and from tissue sections. The cultures caused mucohemorrhagic colitis which by 10 days after inoculation was indistinguishable from the colitis of swine dysentery. Control pigs remained normal. Pigs killed when spirochetes were first seen in the feces had normal colonic mucosa with only a few spirochetes. At the first sign of diarrhea, however, the colonic mucosa was thicker than normal and had many spirochetes. T. hyodysenteriae was confined to regions of hypertrophy and exudation of the large intestine mucosa throughout the course of disease.

Animals↗
PubMedDate not supplied

Six month inhalation studies of pirbuterol acetate aerosol in the beagle dog and squirrel monkey.

Groups of Beagle dogs and Squirrel monkeys were exposed to aerosols of pirbuterol acetate, a new bronchodilator at doses of 0, 200, 400 and 800 micrograms of pirbuterol/kg body weight daily for 6 months. Each group consisted of 4 dogs or 6 monkeys per sex. Dogs were exposed by face mask and monkeys were exposed by head only in a manifold. Plasma drug concentrations indicated that expected levels of drug exposure were achieved in both species. No significant alterations were revealed in physical appearance and body weights, hematological and blood biochemical analyses, urinalyses, ophthalmoscopy, assessment of cardiovascular status, pulmonary function or gross and histopathology. Examination of the respiratory tract showed no morphological changes that could be attributed to pirbuterol acetate inhalation.

Aerosols↗
PubMedDate not supplied

Kinetics of the transplanted heart. Implications for the choice of field-test exercise protocol.

PURPOSE: The transplanted heart shows a slow increase (on transient) of both heart rate (HR) and oxygen consumption (VO2) at the beginning of exercise. The hypothesis used in this study was that this would lead to unacceptably large systematic errors when field predictions of maximal oxygen intake (VO2max) were derived from cycle ergometer tests with a steep ramp function. METHODS: The subjects (27 patients who had received orthotopic heart transplants 6 months previously, and 45 age-matched control subjects) each performed a rapid progressive cycle ergometer test (increments of 16.7 Watts [W] per minute to subjective exhaustion) and a "steady-state" test (two 6-minute stages at one third and two thirds of peak power output). Time constants for HR and VO2 were determined by fitting single exponent equations to the "steady-state" data and noting the time for the difference from the plateau value to reach 36.8% of its initial value. Heart rate and VO2 also were compared between rapid progressive and "steady-state" tests at one third and two thirds of peak power output. RESULTS: At one third of peak power output (46 W in patients, 73 W in control subjects), the respective time constants (mean +/- SE [standard error]) were 60.4 +/- 6.4 and 40.5 +/- 3.0 seconds for VO2 (P < .01), and 130.0 +/- 14.3 and 67.9 +/- 10.0 seconds for HR (P < .001). At two thirds of peak power, the corresponding values were 49.2 +/- 5.5 and 34.7 +/- 2.7 seconds for VO2 (P < .05), and 147.9 +/- 13.0 and 122.2 +/- 4.8 seconds for HR (P < .10). Comparing rapid progressive and "steady-state" readings, the control subjects showed identical values for HR and VO2 at one third of peak power, but at two thirds, the rapid progressive test HR lagged behind the "steady-state" value by 8 +/- 3 beats per minute. The cardiac transplant patients showed a larger HR lag in the rapid progressive tests (109 +/- 12 vs 117 +/- 10 beats per minute, P < .05; 125 +/- 14 vs 141 +/- 14 beats per minute, P < .005). Oxygen consumption also tended to lag slightly at two thirds of peak power (118 +/- 76 mL/min, not significant). CONCLUSIONS: The rapid progressive test protocol yields acceptable field estimates of aerobic power in normal individuals, but the slow acceleration of HR after cardiac transplantation leads to unacceptably large errors if the HR from a rapid progressive test protocol is used to predict maximal oxygen intake (VO2max) in such patients.

Adult↗
PubMedDate not supplied

Screening of different keratin baits for isolation of keratinophilic fungi.

Twenty different keratin-rich substrates were screened as keratin baits for isolation of keratinophilic fungi from different soil sample of Chhindwara District, India. Fungi easily formed colonies on different baits. However, hair, feathers and horns were found to be more suitable than nails, fish fins and fish scales.

Animals↗
PubMedDate not supplied

Anticarcinogenic effect of Commiphora molmol on solid tumors induced by Ehrlich carcinoma cells in mice.

The anticarcinogenic potential of Commiphora molmol (oleoresin) was studied in Ehrlich-solid-tumor-bearing mice. The antitumor activity of C. molmol was evaluated from the total count and viability of Ehrlich solid tumor cells and their nucleic acid, protein, malondialdehyde and glutathione levels at the end of 25 and 50 days of treatment. Furthermore, observations of animal survival rate and measurements of the tumor and body weight were made. The Ehrlich solid tumors were also evaluated for histopathological changes. Treatment with C. molmol (250 and 500 mg/kg/day) was found to be cytotoxic in Ehrlich solid tumors cells. The antitumor potential of C. molmol was comparable to the standard cytotoxic drug cyclophosphamide. This effect of C. molmol was less pronounced after 50 days of treatment. The present study confirmed the cytotoxic and anticarcinogenic potential of C. molmol. Further studies are warranted to explore its mode of action and safety for medicinal use in cancer therapy.

Animals↗
PubMedDate not supplied

In vitro evaluation of inhibitory nature of extracts of 18-plant species of Chhindwara against 3-keratinophilic fungi.

Effect of extract of 18 plant species, viz., Acorus calamus, Adhatoda vasica, Amomum subulatum, Andrographis paniculata, Boerhaavia diffusa, Cassia occidentalis, Centella asiatica, Cymbopogon citratus, Hemidesmus indicus, Hyptis suaveolens, Malvestrum sp., Passiflora edulis, Pergularia daemia, Peristrophe bicalyculata, Shuteria hirsuta, Solanum nigrum, Tecoma stans, and Verbascum chinense on the growth of Microsporum gypseum, Chrysosporium tropicum and Trichophyton terrestre was evaluated and discussed. The sensitivity of the keratinophilic fungi was evaluated by dry-weight method. The maximum inhibition of mycelial growth was shown by M. gypseum (86.62%) followed by T. terrestre (81.86%) and C. tropicum (74.06%) when treated with S. hirsuta whereas the minimum inhibition was exhibited by M. gypseum (0.29%), C. tropicum (0.16%) and T. terrestre (1.76%) when tested with the extract of P. edulis, A. vasica and B. diffusa respectively.

Antifungal Agents↗