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Biomedical subjects

S Popnikolov

Publications and source records attributed to S Popnikolov.

9 recordsLinked to original sources
PubMed1979

[Treatment of cardiac insufficiency in the acute stage of cardiac infarct].

The studies on Strophantin effect upon the hemodynamics in the acute stage of cardiac infarction has revealed that it elevates the pressure in pulmonary artery and reduces the cardiac output, in certain cases deteriorating the patient's state. Furanthril and Droperidol reduce the cardiac output but at the same time diminish the pressure in the pulmonary artery and reduce the pulmonary resistance, thus having a favourable effect on the patient's state. Proceeding from the results obtained, a treatment scheme, including Furanthril, Droperidol and Strophantin, is recommended for the cardiac insufficiency treatment in the acute stage of cardiac infarction depending on the disease onset and the degree of cardiac insufficiency manifested.

Acute Disease↗
PubMed1978

[Comparison of precordial electrocartography with pathologicoanatomic data on 20 patients with recent myocardial infarct].

In 20 patients with recent myocardial infarction, that died till the 40th day after the onset of the disease, a comparison is made of the data from the pathologoanatomical findings with the indices from the precordial electromapping. The changes in the ST segment of the precordial electromapping correlate, to a significant extent, to the weight of the infarction zone in patients with interior site of the myocardial infarction (sigmaST r = 0.89, p less than or equal to 0.01; nST r = 0.62, p less than or equal to 0.01). The indices from the precordial electromapping characterizing the changes in depolarization, are with a considerable less degree of correlation dependence to the weight of the enfarcted zone in the same patients (nQS r = 0.62, p less than or equal to 0.62, p less than or equal to 0.05; sigmaAR r/0.45, p less than or equal to 0.05). In patients with posterior and/or inferior site of the infarction the correlation dependence to the indices from the precordial electromapping is less manifested.

Adult↗
PubMed1978

[Precordial electrocartography (mapping) in cardiac infarct].

After a detailed literature survey the authors share the results from the precordial electromapping with the registration of 30 points upon the chest in 34 patients with ischemic heart disease (30 with transmural infarction and 4 with intermediary syndrome). The following indices were followed up: sigmaST (the sum of the elevation of ST segment measured at 60 msec of the S deflection recording) and the index nST (the sum of the points with an elevation greater than 0.1 mV/1 mm). Both indices well correlate to the level of blood creatine phosphokinase, determined 24 hours after the examination. Due to the close degree of correlation dependence, the two indices are interchangable for the practice. The precordial electromapping reflects the degree of extent of the "myocardial hypoxia" as well as the degree of the disturbed biological activity of the tissues, affected by the myocardial infarction.

Acute Disease↗
PubMed1976

[Several "risk factors" in patients with ischemic heart disease and hypertension].

The observation covers 123 patients (30 males and 43 females). Serum cholesterin and triglycerides of the patients were investigates. All the patients have been put stereotype questions about the preferred kind of main food, body weight changes and nutritional rhythm especially at an early age. The smokers and alcohol consumers were registered. The patients were subdivided into four groups according to their answers: I-without manifested preference to a special type of main food; II - with preference to protein food; III - to carbohydrate and IV - to fats. The formed groups were also characterized by the indices: changes in body weight, nutritional rhythm, body weight above the norm, smoking and alcohol consumption. The results obtained, confirmed the fact that the patients without preference to certain food, are in the habit of rational feeding, comparatively lower lipid indices in serum and the incidence of coronary symptomatics is the lowest in the same group. The scheme according to which the observation was carried out is proposed as a model of epidemiological investigations.

Adult↗
PubMed1976

[Effect of furanthril on several hemodynamic indices during the acute stage of myocardial infarction].

Pulmonary arterial pressure, heart rate and peripheral arterial pressure were followed up by the 15th, 45th and 105th minute post intravenous introduction of 40 mg furanthril in patients with myocardial infarction in acute stage (in 42 cases of 12 patients with left cardiac insufficiency and in 14 cases--of 8 patients without cardiac insufficiency). Furanthril induced clearly manifested pressure decrease in the pulmonary artery in patients with left cardiac insufficiency, developing between the 15th and 45th minute and continuing till the end of the second hour and a negligible elevation of peripheral arterial pressure by the 15th minute, followed by a slight decrease of the latter under the initial value by the 45th and 105th minute. Similar tendency, but less manifested, exists and in patients without cardiac insufficiency. Heart rate is kept unchanged. Furanthril does not induce undesirable hypotonic states when applied in those doses in patients who, as a rule, arenot hyptonics.

Acute Disease↗
PubMed1975

[Rhythmic and conductive disorders in the acute stage of cardiac infarct].

Rhythm and conductive disturbances were established in 170 (63,8%) out of 266 patients with fresh cardiac infarction, in the greatest part with prophylactically applied lidocain i.m. With age advancing a growth in their incidence is established but no statistical difference between the age groups 20-59 and 60-90 was found. Rhythm disturbances are found more frequently in women (81,6%) as compared with the men 58,7%) while the incidence in patients with posterior (62, 5%) and anterior (65, 7%) infarction is the same. Th-disturbances due to electrical instability and failure are more frequent in anterior infarction. Statistical difference (P less than 0,001) was established concerning the rhythm disturbances in patients with heart failure and without it, with a prevalence of sinus tachycardia, auricular fibrillation, ventricular extrasystoles, ventricular tachycardia and bundle branch block. The timely diagnosis and the treatment with medicaments led to the restoration of sinus rhythml in 79 out of 94 disturbances and with electrical shock in 12 out of 16. Parallelly with the classica netirhythm medicines (chinidine and procainamid), newer ones are used as tachmalin, lidocaine, abta-blockers, sympaticomimetics and temporary intracardial electric stimulation.

Acute Disease↗
PubMed1975

[Our experience in using temporary and permanent electric stimulation in conduction disorders].

The results from the observation of 49 patients with complete and incomplete AV block are reported, 33 of them with attacks of MAC syndrome; asystolia 25, ventricular tachycardia and ventricular fibrillation--8. Temporary electric stimulation is carried out in 31 patients (21 with chronic complete AV block and 10 with incomplete and complete with recent cardiac infarction). In all patients with chronic AV block but one, implantation of a permanent artificial rhythm nuide was necessary. The prognosis of the patients with implanted permanent stimulator is determined by the myocardial state, out of six patients with cardiac insufficiency -- three died in a period of 1 to 12 months. Recommendations are presented for active finding out and dispensary control of patients with conduction disturbances and wider application of temporary electric stimulation in the intensive care and treatment units.

Adams-Stokes Syndrome↗
PubMed1975

[Experience with the electrophoretic separation of lipoproteins on Celogel].

Hydroxycellulose gel foils (cellogel) were used for the serum lipoproteid separation in conditions of routine practice, Ninety four serum tests of patients with hypertension were investigated as well as with coronary disease, essential hyperlipoproteidemia, diabetes and infarction-acute stage. Total cholesterol and triglycerides in serum were determined to the same patients. The ratio between the numerical values of the latter is confronted to the ratio between the percentage part of beta-lipoproteids and the sum of the same parts of chylomicrons and pre-beta-lipoproteids. The results are presented graphically. The phenotypes were attempted to be determined to a separate group of patients with manifested hyperlipoproteidemia.

Acute Disease↗