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Biomedical subjects

S Pitlik

Publications and source records attributed to S Pitlik.

108 records · Page 6Linked to original sources
PubMed1977

Mural endocarditis associated with recurrent false aneurysm of the left ventricle.

Acute bacterial endocarditis developed in a 65-year-old man two years after surgical resection of a false aneurysm of the left ventricle. The patient had cerebral embolic manifestations, and coagulase-positive Staphylococcus aureus was cultured from each of six blood samples. A pericardial friction rub and a changing pansystolic murmur appeared during the third week of hospitalization. The presence of a false aneurysm was once again demonstrated on ventriculographic studies. This was successfully repaired, employing cardiopulmonary bypass. The sequence of events in this patient suggests that bacterial endocarditis at the site of a previous cardiomyotomy might have led to the development of the second pseudo-aneurysm.

Aged↗
PubMed1977

Portal hypertension and esophageal varices in hemangiomatosis of the spleen.

Bleeding esophageal varices and severe portal hypertension developed in a patient with capillary hemangiomatosis of the spleen. No signs of cirrhosis were found at postmortem examination, and preoperative celiac angiography suggested an intrasplenic shunt as the cause of the high portal pressure. Although a very rare condition, this possibility should be considered in the differential diagnosis of esophageal varices.

Arteriovenous Fistula↗
PubMed1975

Fatal undiagnosed tuberculosis in hospitalized patients.

Thirty-seven cases of active tuberculosis were misdiagnosed in Chaim Sheba Medical Center in the years 1964-1974. The diagnosis was made only after death. Twenty-one patients were over 60 years of age. Eleven had hematological disorders, and 12 received steroids (sometimes with immunosuppressive or cytotoxic drugs). Misdiagnosis of miliary tuberculosis is a growing problem and demands special attention. The postmortem examination must be systematic and must include bacteriological and histological studies for establishment of the correct diagnosis.

Adolescent↗
PubMedDate not supplied

Epidemiology of candidemia--a nationwide survey in Israel.

Bloodstream infections with Candida are often lethal and have been reported to be increasing in frequency. The current retrospective study describes the magnitude and epidemiological characteristics of candidemia in all western-type hospital facilities in Israel in 1994. Comprehensiveness of the data from the reporting hospitals was checked by cross-study of the data from the infectious diseases records and from the hospitalization records. Vital status of all reported cases was evaluated 1 year after the diagnosis. Data on 298 newly diagnosed cases of candidemia were received from 14 of the 18 general hospitals in Israel. The proportion of candidemia in the Israeli hospitals ranged from 0.1 to 0.01% of all admissions, with a mean of 0.05%. The incidence of candidemia differed significantly between the wards from 4-5/10,000 in general surgery and internal medicine wards to about 60/10,000 and 80/10,000 in intensive care and preterm units, respectively. Of all detected cases 53.6% were Candida albicans. Another nine specific species of Candida (mainly Candida parapsilosis, Candida tropicalis and Candida glabrata) were detected, with major differences between the various hospitals. The species of Candida differed significantly by sex and age. Of the cases of candidemia 21.5% died within 30 days of the isolation of the pathogen. The one-year mortality rate was 31.9%. Species-specific 30-day mortality rate was highest for C. glabrata. Throughout the analysis, C. glabrata emerged as a unique cause of candidemia, producing higher mortality, appearing at a younger age and predominating among females.

Adolescent↗
PubMedDate not supplied

Nonenteric infections acquired through contact with water.

In recent years water has been recognized as an important vehicle for extraintestinal infection. A variety of pathogens are acquired through occupational, recreational, and even therapeutic contact with water. The nature of nonenteric waterborne disease is often determined by the ecology of aquatic pathogens. Such infections are of basically two types: superficial, involving damaged or previously intact mucosae and skin; and systemic, often serious infections that may occur in the setting of depressed immunity. A broad spectrum of aquatic organisms, including viruses, bacteria, fungi, algae, and parasites, may invade the host through such extraintestinal routes as the conjunctivae, respiratory mucosae, skin, and genitalia.

Bacterial Infections↗
PubMedDate not supplied

Urinary soluble VCAM-1 in systemic lupus erythematosus: a clinical marker for monitoring disease activity and damage.

OBJECTIVE: To determine the urinary levels of soluble vascular cell adhesion molecule-1 (VCAM-1) and intercellular adhesion molecule-1 (ICAM-1) in patients with systemic lupus erythematosus (SLE) and to assess their relationship with clinical and laboratory features and the degree of activity and damage associated with the disease. METHODS: The study sample included 24 consecutive patients with SLE. 24-hour urine samples were collected for the determination of soluble VCAM-1 and ICAM-1 levels by ELISA. Disease activity was defined by the SLE Disease Active Index (SLEDAI) and disease outcome by the Systemic Lupus International Collaborating Clinics/American College of Rheumatology (SLICC/ ACR) damage index. RESULTS: The urinary soluble VCAM-1 level was significantly higher in patients with SLE compared to normal controls (32.35+/-34.27 vs. 4.66+/-3.8 ng/mg creatinine, p = 0.0005) and statistically significantly correlated with disease activity (SLEDAI), a low serum C3 level, decreased creatinine clearance and albuminuria, as well as with disease damage (SLICC/ACR damage index). In contrast, the urinary soluble ICAM-1 level was not significantly higher in the patients' group compared with the controls (4.5+/-5.19 vs. 2.72+/-2.31 ng/mg creatinine, p=0.2), but was statistically significantly correlated with hematuria and albuminuria. CONCLUSION: Our data suggest that the urinary level of soluble VCAM-1 significantly correlates with overall disease activity and damage scores, but not with nephritis in SLE.

Adult↗