Biomedical subjects

S Picard

Publications and source records attributed to S Picard.

95 records · Page 6Linked to original sources

PubMedDate not supplied

Can personality traits predict psychotherapy outcome?

Ninety-six new admissions to a psychiatric outpatient clinic who attended a median of 14 therapy sessions completed a self-report Personality Profile Index prior to their first session. This index provides scores on eight dimensions of personality, a conflict measure, and a measure of social desirability. Scores were correlated with number of sessions and outcome as measured by a Symptom Checklist and by a Global Assessment Scale (GAS). Improvement was significantly related to number of sessions attended. Patients scoring high on being rejecting of others (rejection) were significantly less likely to show improvement after therapy. Rejection, aggression, passivity, and conflict were significantly related to the extent of symptoms and problems with which patients presented at the clinic.

Adaptation, Psychological↗

PubMedDate not supplied

Relationships between psychological mindedness and personality traits and ego functioning: validity studies.

Two studies further investigated the psychometric properties of the self-report Psychological Mindedness Scale (PMS), which has been shown to have good internal consistency and evidence of predictive and divergent validity. Its construct validity was investigated by assessing (1) whether total scores on the PMS of a group of medical students attending a personnel clinic in a psychiatric outpatient setting would be related in theoretically expected ways to their scores on a personality test; and (2) whether total scores on the PMS of a group of regular clinic patients would have the expected theoretical relationships to scores on a measure of ego functions. The findings of both studies provided support for the construct validity of the PMS.

Adaptation, Psychological↗

PubMedDate not supplied

Gender differences in recalled parental childrearing behaviors and adult self-esteem.

A retrospective questionnaire study investigated gender differences in the relations between the self-reported self-esteem of 155 psychiatric adult outpatients and their recalled experience of their parents' behavior toward them as children. There were no significant sex differences in degree of self-esteem. However, it had a higher correlation to parenting variables for the men than for the women, with maternal predictor variables accounting for 36% and paternal predictors accounting for 32% of the variance in the men's self-esteem. Neither combined maternal nor combined paternal variables were significant predictors for women. For men, parental acceptance/ autonomy was significantly and positively related and inconsistency negatively related to self-esteem. Paternal rejection but not maternal rejection was significantly associated with low self-esteem only for the women. The greater amount of variance explained by childrearing variables in the men's self-esteem scores was attributed to the earlier ego development and consequent increased individuation in women.

Adolescent↗

PubMedDate not supplied

Electrophysiological effects of dofetilide in an in vitro model of "border zone" between normal and ischemic/reperfused myocardium.

BACKGROUND: To evaluate both class III activity and antiarrhythmic action of dofetilide at the level of the "border zone," we investigated its electrophysiological effects on guinea pig ventricular strips submitted partly to normoxia (normal zone, NZ) and partly to simulated severe ischemia, then reperfusion (altered zone, AZ). METHODS AND RESULTS: Because of the differential class III effects of dofetilide in normal and ischemic regions, the dispersion of the action potential duration at 90% repolarization (APD(90)) between NZ and AZ was reduced by 5 nmol/L of drug during early ischemia (at 10 minutes, APD(90) NZ/APD(90) AZ was 1.68+/-0.22 versus 2.82+/-0.17 in control, P<0.05), whereas 50 nmol/L dofetilide worsened it during late ischemia (at 30 minutes, APD(90) NZ/APD(90) AZ was 4.62+/-0.76 versus 2.57+/-0.21 in control, P<0.05). Concomitantly, dofetilide at 5, 10, and 50 nmol/L abolished the early extrastimulus (ES)-induced arrhythmias, and at 10 and 50 nmol/L, it significantly enhanced the incidence of late spontaneous repetitive responses (in 86% and 75% of preparations treated with 10 and 50 nmol/L, respectively, versus 25% in control, P<0.05). During reperfusion, dofetilide at 5, 10, and 50 nmol/L exhibited concentration-dependent class III effects, as it did in the NZ, and did not modify the incidence of spontaneous arrhythmias. CONCLUSIONS: Dofetilide 5 nmol/L decreased APD(90) dispersion between NZ and AZ and reduced the early ES-induced arrhythmias. However, dofetilide 50 nmol/L increased APD(90) dispersion, and at 10 and 50 nmol/L, it increased the late spontaneous arrhythmias.

Action Potentials↗

PubMedDate not supplied

In vivo regulation of enzymes controlling aldosterone synthesis in pregnant rats.

There are two main regulatory sites of aldosterone biosynthesis, the early rate-limiting step by the P450scc and the final steps by the P450aldo. We have already demonstrated that, during gestation, activity and mRNA levels of P450aldo are increased. It has been shown that changes in sodium and potassium in the diet modulate the expression of P450aldo in adrenal zona glomerulosa (ZG). In the present study, we compared the effects of low-sodium (Na+) and high-potassium (K+) diet on the expression of enzymes controlling aldosterone synthesis during gestation. Pregnant and nonpregnant rats were randomly assigned to control group or to group receiving low Na+ or high K+ diet during the last week of pregnancy. By the end of the treatment, the two diets induced increases of plasma aldosterone and P450aldo mRNA levels in nonpregnant and pregnant rats. However, plasma renin activity and P450scc mRNA levels were only in the pregnant group fed the low Na+ diet. High K+ diet had no effect on these parameters. We, thus, suggest that the renin-angiotensin system and the enzymes implicated in aldosterone synthesis are differently regulated during gestation.

Aldosterone↗