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Biomedical subjects

S Pezzotta

Publications and source records attributed to S Pezzotta.

At least 55 records · Page 3Linked to original sources
PubMed1977

Chemotherapy of human nervous system tumors: influence on cerebrospinal fluid sterols.

The cerebrospinal fluid levels of cholesterol, desmosterol, and the ratio 100 D:C taken from a study of 59 patients are reported. The patients, who had tumors of the nervous system, underwent neurosurgery, radiotherapy, and chemotherapy with 1,3-bis(2-chloroethyl)-1-nitrosourea or 1-(2-chlororethyl)-3-cyclohexyl-1-nitrosourea. The relationships among the levels of these three parameters and the clinical and neuroradiologic evolution are discussed.

Adult↗
PubMed1977

[Neurosurgical emergencies: cranio-cerebral injuries and their diagnosis and therapy (author's transl)].

The neurotraumatological case material of the Neurosurgical Clinic of the University of Pavia, from the August 1st 1972 to July 31st 1975, includes N. 122 patients, submitted to neurological surgery. All data are examined and discussed in relation to age, to the coma level, to the type of endocranial lesion and the results obtained are compared with the data of literature. The incidence of associated lesions, both endocranial and in other regions, is made standing out more clearly. The importance of an early diagnosis, by neuroradiological tests, is made cospicuous in order to get a correct surgical therapy. The survival is discussed in relation to the type of surgical act and of pathology.

Accidents, Occupational↗
PubMed1976

Chemotherapeutic effects of some alkylating derivatives of nitrosourea on the development of tumors transplacentally induced in rats by ENU.

The application of BCNU, CCNU and MeCCNU has been shown to greatly reduce the number of tumors induced in rats by transplacentally administered ENU and to inhibit the full development of tumor proliferation. Moreover, no neurinomas appeared after treatment with CCNU. The application of GCNU proved to be much less effective. Our statistics in the form of tables showing these findings are included and discussed.

Alkylating Agents↗
PubMedDate not supplied

Epidermoid and dermoid tumors.

The authors report their experience in the surgical treatment of intracranial dermoid and epidermoid tumors. These lesions are rare but may, in most of the occasions, be completely resected allowing a complete cure of the patient. The usefulness of the most recent diagnostic tools is discussed and the surgical indications, complications and results are reviewed in comparison to the most significant literature reports.

Adult↗
PubMedDate not supplied

Surgical treatment of craniosynostosis.

The authors report their experience with the cranial recontouring techniques in the treatment of craniosynostoses. The results obtained treating sixteen children suggest that these techniques can be tolerated well by patients, with very limited postoperative complications. It is underlined that the precocity of the surgical treatment is an indispensable prerequisite in order to obtain satisfactory clinical and cosmetic results.

Craniosynostoses↗
PubMedDate not supplied

Outcome following acute supratentorial subdural hematoma in pediatric age.

The authors report their experience in surgical treatment of 39 cases of acute subdural hematoma, followed by intensive therapy and physiokinesitherapy. The causes of head injuries, types of fractures, localization of the hematomas, concomitant lesions, diagnostic and therapeutic clinical features are discussed. The most common neurological evaluation scales for rating the state of comas are used for comparing the cases of head injury in adults (Glasgow Coma Scale) and in children (Children's Coma Scale). The Authors also report clinical follow-up, morbidity, and general mortality rate. Moreover, they emphasize the frequency and clinical importance of cases with unapparent symptomatology and demonstrate that extrinsic eye movement is a very important factor for prognostic evaluation.

Acute Disease↗
PubMedDate not supplied

Growing skull fractures of childhood. Case report and review of 132 cases.

Authors report a case of growing skull fracture, unusual complication of linear skull fracture in infancy and childhood. A review of 132 cases reported in literature is done with an analysis of general characteristics of this lesion. The most common localization is parietal (50%); clinical presentation is represented by development of seizures (54 cases), focal neurological deficit (57 cases) or loss of consciousness (50 cases). In 50% of cases interval time between head injury and first symptom varies between 1 day and 1 year. After the first year of age the 34.4% of patients develop seizures and 59% present loss of consciousness. Among patients from 1 day to 6 months of age, 46% develop seizures, 38% focal neurological deficit and 21% loss of consciousness. Asymptomatic presentation is more common in fronto-parietal or fronto-parieto-occipital localizations. In parieto-occipital and occipital localization (30 cases), 13 patients (43.3%) have seizures, 36.7% a focal neurological deficit and 60% loss of consciousness. In parieto-temporal localization there is a higher probability of seizures (62.5%) and loss of consciousness (62.5%). The long-term follow-up and the functional recovery in patients which undergo surgery is linked to the clinical presentation and early diagnosis.

Arachnoid↗
PubMedDate not supplied

Diagnosis and treatment of post-traumatic hydrocephalus.

From August 1972 to December 1980, 36 patients were operated on at the Neurosurgical Clinic of the University of Pavia for post-traumatic hydrocephalus. The materials and methods for making a correct diagnosis of post-traumatic hydrocephalus and for follow-up assessment are discussed. Of our patients who were surgically treated 45% improved, 22% remained unchanged, 22% died and we have no follow-up data on the remaining 11%. Comparisons are made with data from the literature regarding the immediate and long-term results.

Adolescent↗