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Biomedical subjects

S Petersen

Publications and source records attributed to S Petersen.

161 records · Page 9Linked to original sources
PubMed1977

The possible relation between postpartum exacerbation of hyperthyroidism and neonatal thyrotoxicosis.

Hyperthyroidism is generally considered to be ameliorated during pregnancy, and there appears to be a high incidence of postpartum exacerbation. These phenomena have to our knowledge not been related to neonatal thyrotoxicosis, a transient hyperthyroidism seen only in newborns of previous or current hyperthyroid mothers. The first of two siblings of a previously thyrotoxic mother had marked symptoms of neonatal thyrotoxicosis and high levels of thyroid hormones. The mother had not received antithyroid treatment during her first pregnancy. During her next pregnancy she was treated with propylthiouracil from the second trimester. This infant had only minimal thyrotoxic signs but almost as high levels of thyroid hormones during the neonatal period as the elder. The mother had no signs of postpartum exacerbation but her thyroid hormones were significantly elevated in the postpartum period analogous to the infants. Neither the mother nor the infants presented any increase in thyroid-stimulation hormone and long-acting thyroid stimulator during the hyperthyroid periods. The possibility is discussed, that postpartum exacerbation of hyperthyroidism and neonatal thyrotoxicosis may be related. They could be the result of a changed balance between a thyroid stimulator and an inhibitor after birth.

Female↗
PubMed1977

Neonatal septic osteo-arthritis due to umbilical artery catheterisation.

Three cases of neonatal septic osteo-arthritis due to umbilical artery catheterisation are described. The clinical features were characteristic. A week after removal of the catheter a septic osteo-arthritis developed. The etiological agent in all three cases was Staphylococcus aureus, resistant to penicillin. The disease is probably caused by haematogenous spread of septic clots from thrombus formation on the catheter. Symptoms and signs were few and vague. It is suggested that septic osteo-arthritis due to umbilical catheterisation is more frequent than hitherto believed, and low-grade forms might remain undiagnosed.

Catheterization↗
PubMed1977

Neonatal thyrotoxicosis.

Neonatal thyrotoxicosis is a transient hyperthyroidism in infants of mothers with current or previous thyrotoxicosis. The pathogenesis have been accepted to be placental transfer of maternal thyroid stimulating immunoglobulins. Of two siblings from a previous thyrotoxic mother the first had marked symptoms of thyrotoxicosis but during the second pregnancy antithyroid treatment was given to the mother and though the child had high levels of thyroid hormones for 6 weeks it had only minimal symptoms of thyrotoxicosis.

Female↗
PubMed1977

Hyperthyroidism during pregnancy treated with propylthiouracil. The significance of maternal and foetal parameters.

Hyperthyroidism during pregnancy may be dangerous to the infant. The major risks are prematurity and neonatal thyrotoxicosis. The latter may be due to placental transfer of thyroid stimulating immunoglobulins from mother to fetus. Of two siblings of a previously thyrotoxic mother the first had marked symptoms of neonatal thyrotoxicosis after a pregnancy where no antithyroid treatment was given. The second child had only minimal thyrotoxic symptoms but almost as high levels of thyroid hormones as the first. During the second pregnancy propylthiouracil was given to the mother from 26 weeks' gestation, because of increased fetal movements and fetal tachycardia. Fetal movements and fetal heart rate were considered to be most valuable indicators of thyroid function in the fetus. Intense control is necessary from the beginning of the second trimester.

Adult↗
PubMed1976

Some effects of light on the viability of rhodopsin-containing halobacteria.

Under starvation conditions, rhodopsin-containing halobacteria show a light-accelerated death under aerobic conditions. This is attributed to photooxidative processes. Under anaerobic conditions, halobacteria die rapidly in the dark, and light prevents death. Since it has been shown by others that lightdriven ATP synthesis can occur under anaerobic conditions, it is postulated that rhodopsin-mediated photophosphorylation is of survival value for this organism in the brines in which it lives, especially because the solubility of oxygen is low in highly saline waters and anaerobic conditions can often develop.

Aerobiosis↗
PubMed1976

The temporal pattern of feeding over the oestrous cycle of the mouse.

The detailed temporal pattern of feeding in female mice was measured by an automated method over the oestrous cycle whilst feeding on either of two foods differing in stimulus characteristics, but of similar calorific value. The total time spent feeding varied systematically over the cycle, being increased for sweet food and decreased for laboratory chow at the time of sexual receptivity. and increased for both foods towards the end of the cycle. The temporal pattern is analysed into a number of variables, which are seen to alter in different ways over the oestrous cycle. The pro-oestrus disturbance is due to alterations in meal size brought about solely by changes in mean bout length, themselves products of variations in the initial bouts of the meal. Inter-meal interval is unrelated to changes in meal size at this time, allowing the latter to affect food intake. The changes towards the end of the cycle are produced by alterations of meal frequency at constant meal size. It is argued that separable 'phasic' and 'tonic' effects of reproductive condition on feeding may therefore be identified, and that they might possibly have different functions.

Animal Feed↗
PubMed1976

Pleural empyema in a newborn infant. An unusual cause of respiratory distress.

In a 2-day-old baby with symptoms of respiratory distress a right-sided pleural empyema caused by haemolytic streptococci was found. Possible sources of infection are discussed. The mother had purulent discharge from a tooth a few weeks before delivery, and this may have been the focus. The baby was treated with pleural drainage and ampicillin with good result.

Empyema↗
PubMedDate not supplied

Beyond hospice care: a survey of community outreach programs.

In an editorial by David Lescohier (The American Journal of Hospice & Palliative Care), the tough dilemma faced by many hospices today is our acceptance into the mainstream of the medical delivery system. Hospitals have found that offering specialized adjunct programs has helped them maintain an edge in a competitive environment. Part I of this article contains the results of a national survey which explored the differences in the hospices that are pursuing outreach programs and the direction of those programs. Part II provides results and discussion of the benefits, obstacles and problems in several types of outreach: counseling, schools, pre-hospice and day care.

Community Health Services↗
PubMedDate not supplied

An experimental study on carbon flow in Escherichia coli as a function of kinetic properties and expression levels of the enzyme phosphoglucomutase.

Mutants of Escherichia coli deficient in phosphoglucomutase accumulate amylose when the cells are grown on maltose or galactose as carbon source. In the presence of physiological levels of phosphoglucomutase, most of the sugar is catabolized, leading to strongly reduced levels of amylose accumulation. By varying the expression level of heterologous phosphoglucomutase, we show that the minimum level needed to block amylose accumulation corresponds to a phosphoglucomutase activity of 150-600 nmole substrate transformed per min per mg of total soluble protein. Mutant phosphoglucomutases with strongly reduced Vmax values and increased Km values for the substrate glucose-1-phosphate or the co-substrate glucose-1,6-diphosphate, could also reduce amylose accumulation, but much higher enzyme expression levels were required.

Carbon↗