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Biomedical subjects

S Peters

Publications and source records attributed to S Peters.

317 records · Page 18Linked to original sources
PubMedDate not supplied

[Electrocardiography changes in scoliosis and kyphosis deformities of the thorax].

Preoperative electrocardiograms and lung function tests in patients with severe scoliosis were compared. The electrocardiograms were analysed by recognizing signs of right ventricular hypertrophy and signs of right ventricular strain. The results are as follows: Dates of electrocardiography and lung function testing show a very good correlation. Scoliotic and kyphotic deformities show a clear dependency on grade of scoliosis and age. Electrocardiographic changes do not depend on additive kyphotic deformity.

Adolescent↗
PubMedDate not supplied

[Bone density in children and adolescents with rheumatic diseases. Preliminary results of selective measurement of trabecular and cortical bone using peripheral computerized tomography].

UNLABELLED: Selective measurements of bone mineral density (BMD) of trabecular and cortical bone at the ultradistal radius were made in 27 children with rheumatic diseases and in age- and sex-matched healthy controls using peripheral quantitative computed tomography (pQCT). RESULTS: Mineral density of trabecular bone (-34,5%) and total bone mineral density (-18,9%) differed significantly between patients and controls (p < 0.01). BMD of the cortical bone (-13,6%) did not differ significantly between the groups. There was no difference in BMD in patients with systemic or non-systemic diseases. BMD did not correlate with duration of disease or steroid medication. CONCLUSIONS: Total bone mineral density and trabecular bone density are decreased in children and adolescents with sytemic and non-systemic rheumatic diseases. Age of onset of disease and steroid medication did not correlate with bone mineral density. PQCT has the advantages of low local and no total body radiation, high sensitivity, high reproducibility and selective measurement of different bone compartements. Because selective measurement can be made in metabolically active trabecular bone changes of BMD can be detected at an early stage before the whole bone is affected. With this method therapy for chronic diseases affecting bone density can be initiated and the course of the disease can be followed.

Adolescent↗
PubMedDate not supplied

Subretinal injection of rod outer segments leads to an increase in the number of early-stage melanosomes in retinal pigment epithelial cells.

Our study was performed to test the hypothesis that subretinally injected protein can induce melanogenesis in the retinal pigment epithelium (RPE). Rod outer segments (ROS) were isolated from cattle eyes and injected into the subretinal space of Long Evans rats. Five days after surgery, the injected eyes were investigated by electron microscopy. The number of early-stage melanosomes and small melanin granules was compared in injected and noninjected eyes. It was found that the injected ROS were phagocytized by the RPE cells, and the number of early-stage melanosomes in the RPE was significantly increased in injected eyes compared to eyes without injection. The ROS-containing endosomes fused with melanolysosomes in which melanogenesis took place. The increased number of early-stage melanosomes indicates new formation of melanin.

Animals↗
PubMedDate not supplied

Biomechanical characteristics of the human trachea.

Previous experiments using mercury-in-Silastic strain gauges in dogs revealed the trachea to be a dynamic organ. The cartilaginous rings and intercartilaginous membranes are unique in adapting to the physiologic demands of respiration, deglutition, and gravity. Alterations in tracheal biomechanics following segmental tracheal resection were also documented. In the present study, a new device was used to measure the stress-strain characteristics of the human trachea. The machine can be used to measure tension across trachea rings or the entire trachea. The results of these experiments indicate that the human trachea is a complex biomechanical organ and that it responds distinctively to stress.

Biomechanical Phenomena↗
PubMedDate not supplied

Evaluation of an innovative cost-effective programme for brain injury patients: response to a need for flexible treatment planning.

There is clinical support for the hypothesis that brain-injured patients benefit from the high degree of structure provided by an inpatient rehabilitation programme. However, they often experience mild to moderate regression in behavioural and functional skills when they are discharged to home. This paper presents an evaluation of an innovative phase within an acute brain injury programme designed to facilitate the patient's approach towards independence. 'Step-Up' programme patients, who spent the last weeks of their inpatient length of stay residing in a transitional living setting, were compared with inpatients who participated in the regular therapy programme. Eighteen months of descriptive data regarding cognitive (Rancho) and functional (Barthel) levels for 31 patients are compared. Based on survey data, the Step-Up patients reported more independence in activities of daily living than did inpatients. The Step-Up programme also proved to be more cost effective than the inpatient alternative. Challenges to innovative programming presented by payors, families, and clinicians are discussed.

Activities of Daily Living↗
PubMedDate not supplied

Microwave thawing of frozen minibag admixtures.

An efficient system is described for the preparation of high volume minibag admixtures e.g. cefazolin. The system includes use of bulk reconstitution, freezing and microwave thawing techniques; special admixture dosage forms; and, the use of technical staff. The system can be utilized in any centralized, intravenous, admixture service where the workload is demanding for existing staff.

Cefazolin↗
PubMedDate not supplied

Carcinomas unresponsive to either cisplatinum or anti-EGFR therapy can be growth inhibited by combination therapy of both agents.

BACKGROUND: Previously we demonstrated that the antitumor efficacy of monoclonal antibodies against the EGFR (epidermal growth factor receptor) of human tumor xenografts mainly depends on the EGFR content of tumors rather than on the tumors' entity. In this study we wanted to elucidate whether the described cumulative effect of cisplatin and Anti-EGFR therapy also depends on the EGFR expression. MATERIALS AND METHODS: Xenotransplanted carcinomas with different EGFR levels were treated with monoclonal antibodies against the EGFR (EMD 72000 and EMD 55900), cisplatinum and a combination of both. RESULTS: Each monoclonal antibody alone led to an EGFR-dependent significant tumor growth reduction. Cisplatinum alone had no growth inhibitory effects on tumors with high content in contrast to those with low EGFR content. The combination of antibodies with cisplatinum resulted in an EGFR-independent tumor growth inhibition which was stronger than observed in the case of monotherapy. DISCUSSION: The obtained results may address upcoming phase I/II trials to use Anti-EGFR/Cisplatinum therapy regardless of the EGFR content of tumors.

Adenocarcinoma↗
PubMedDate not supplied

High-dose cytarabine neurotoxicity: MR findings during the acute phase.

The authors report an acute cerebral and cerebellar syndrome in a patient treated with high-dose cytarabine. Diffuse high-intensity lesions in the central white matter on T2-weighted MR completely reversed with resolution of the clinical syndrome. Although the autopsy revealed cerebellar injury, the cerebral cortex was grossly and microscopically normal, consistent with a reversible process.

Acute Disease↗