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Biomedical subjects

S Peters

Publications and source records attributed to S Peters.

At least 253 records · Page 14Linked to original sources
PubMed1984

A slow EPSP in mammalian inferior mesenteric ganglion persists after in vivo capsaicin.

The non-cholinergic slow excitatory postsynaptic potential (EPSP) in the guinea pig inferior mesenteric ganglion (IMG) is believed to be mediated by substance P (SP). Yet, in ganglia of guinea pigs treated with capsaicin (50, 100, or 350 mg/kg, s.c.), a compound that depletes SP from sensory neurons, slow EPSPs were only 50% smaller in amplitude than those in vehicle-treated controls; this was true at all dosages. When ganglia from capsaicin-treated animals were desensitized to SP, slow EPSP amplitude was decreased by 50% from predesensitization values. These data indicate that capsaicin does not eliminate the slow EPSP in the IMG and suggest that both SP and another transmitter are involved in co-mediating this response.

Animals↗
PubMed1984

Immunoperoxidase examination of cutaneous infiltrates of mycosis fungoides and large-plaque atrophic parapsoriasis with OKT10.

A monoclonal antibody (OKT10), which was developed recently, reacts with pro-thymocytes, T cell acute lymphoblastic leukemia (ALL) cells, cells in normal bone marrow (including plasma cells), and activated T cells. Tissues from patients with cutaneous T cell lymphoma were studied for the presence of OKT10-reactive cells with the use of an indirect immunoperoxidase technic. OKT10-reactive cells were identified in three of eight cases of mycosis fungoides, one of two cases of Sézary syndrome, with an equivocal reaction in one of ten cases of large-plaque parapsoriasis and in one of seven positive patch tests (allergic contact dermatitis). The biologic and possible clinical implications are discussed.

Antibodies, Monoclonal↗
PubMed1984

[Progression and regression of coronary sclerosis in the angiographic image].

The natural history of coronary artery disease has to be studied by comparing coronary angiograms of the same patient taken at different times. However, conclusions from repeated angiographic studies are fraught with substantial errors mainly because of: 1. patients selection, 2. variable time interval and 3. technical pitfalls. Despite this bias published interval studies demonstrate that coronary atherosclerosis predominantly is a progressive disease: after 2-3 years 50% to 60%, after 3-4 years 60% to 70% and after 5 years more than 80% of patients demonstrate progressive coronary artery disease at angiography. In addition, quantitative evaluation of coronary angiograms reveals that progression of coronary artery disease: 1. has a variable pattern and pace in each coronary artery and 2. predominantly involves initially normal coronary artery segments. From all clinical and angiographic parameters under scrutiny progressive coronary artery disease is significantly correlated to: abnormal lipid levels at the time of the first angiogram, a period of unstable angina pectoris, interval myocardial infarction and initial severity of coronary artery obstruction. It has to be emphasized, however, that in the individual patient the speed of progression is highly variably supporting the concept of different underlying pathophysiological mechanisms (primary/secondary progression). Regression or coronary stenosis is a rare phenomenon which may occur spontaneously and is anecdotally reported in patients after vigorous treatment of severe hyperlipoproteinemia.

Angina Pectoris↗
PubMed1983

OKT 9 reactivity in mycosis fungoides and large plaque (atrophic) parapsoriasis.

A monoclonal antibody OKT 9 which detects a determinant expressed by a variety of proliferating cell types has been recently developed. This antibody was used in conjunction with the immunoperoxidase technique to study the cutaneous lymphoid infiltrates of nine patients with mycosis fungoides, one patient with lymphomatoid papulosis, two patients with Sézary syndrome, and ten patients with large plaque atrophic parapsoriasis (a condition which may terminate in overt mycosis fungoides.) OKT 9 reactive cells were identified in all cases of mycosis fungoides examined, in one case of lymphomatoid papulosis, one of two cases of Sézary syndrome, and one of ten cases of large plaque atrophic parapsoriasis. These results suggest that further studies using OKT 9 should be performed to assess whether OKT 9 reactivity may be used as a prognostic marker in cutaneous lymphomas and prelymphomas.

Antibodies, Monoclonal↗
PubMed1983

Demonstration of cells bearing the OKT6 determinant in human tonsil and lymph node.

An immunoperoxidase study was carried out on human tonsil (15 specimens) and human lymph node (5 specimens) using OKT6, a monoclonal antibody which was raised against a determinant on immature thymocytes. OKT6-positive cells were identified in the crypt epithelium of all tonsils examined and in occasional clusters in the interfollicular areas of two lymph nodes. OKT6 has recently been shown to react with epidermal dendritic cells (Langerhans' cells). This study confirms that OKT6-reactive cells may be found outside the thymus. The pattern of staining obtained suggests that OKT6 reactivity belongs to a dendritic subpopulation. The significance of the finding in relation to physiology and pathology is discussed. These physiological findings may also be relevant to the immunotherapy of T-cell lymphomas.

Antibodies, Monoclonal↗
PubMed1983

Minor physical anomalies and behavior in children: a review.

The recent literature concerning minor physical anomalies (MPA) and their relation to behavior is reviewed. Research seems to indicate that for males there is considerable consistency in the results but the finding with females is tenuous at best. It appears that a high number of MPA are evident in several pathological groups of boys, as compared with normal controls. In addition, there is a suggestion that MPA are correlated with severity of hyperactivity, IQ, and school achievement. Furthermore, there is also a relationship between a high number of MPA and obstetrical complications. The etiology of MPA and their utility in predicting pathological behavior is discussed.

Attention Deficit Disorder with Hyperactivity↗
PubMed1983

Differing effects of pectin, cellulose and lignin on stool pH, transit time and weight.

Randomized cross-over studies were undertaken to determine the effects of daily dietary supplements of pectin (12 g/d), cellulose (15 g/d) and lignin (12 g/d) on stool characteristics of healthy volunteers. Detailed dietary records were kept throughout the study. Stool collections over 48 h were used to determine mean stool pH and weight. The single stool transit time was measured using radio-opaque markers. Pectin did not significantly alter the mean stool pH, transit time or 24 h wet weight. Cellulose lowered the mean stool pH from 6.38 to 6.12, decreased mean stool transit time by 27% and increased mean wet stool weight by 57%. Lignin lowered the mean pH from 6.34 to 6.25, decreased the stool transit time by 20% and increased stool weight by 27% but these changes were not statistically significant. These findings have shown that individual fibre components have different colonic metabolic effects and support the view that associations between dietary fibre intakes and diseases such as colorectal cancer should be evaluated with regard to the type of fibre components consumed.

Adult↗
PubMed1983

Recurrent abdominal pain: a psychogenic disorder?

A controlled study of 30 children with recurrent abdominal pain and 30 pain free children failed to show any statistically significant differences between the groups on a variety of psychological variables thought to be associated with psychogenicity. A psychogenic basis has often been assumed as the cause in diagnosis of recurrent abdominal pain when clinical examination and laboratory tests show no organic or medical reason. We emphasise that establishing a psychogenic cause is only indicated where there is positive evidence for psychological factors such as family or school stress, extreme personality characteristics, or modelling of family pain behaviour.

Abdomen↗