Biomedical subjects
S Perveen
Publications and source records attributed to S Perveen.
Prevalence of parasitic infections in a rural area of Karachi, Pakistan.
OBJECTIVE: To find the prevalence of human intestinal pathogenic parasites. SETTING: The study was conducted in Konkor, Gadap, District East, Karachi. METHODS: After taking the verbal consent, all the villagers, selected by area sampling technique were interviewed by a structured questionnaire and then each person in the house was provided with a clean, plastic container to collect the stool samples. Samples were examined using normal saline, iodine preparation and zinc floatation technique where appropriate. RESULTS: Out of 263 residents 185 tested for intestinal parasites and 88 (47.5%) had pathogenic parasites. The distributions of parasites were Giardia lamblia 50% and Entamoeba histolytica 48.86%. Statistically none of the socio-demographic variables were associated except education and age group. CONCLUSION: In the light of the study result it is concluded that there is a high prevalence of parasitic infection in the community and an intervention strategy including health education program should be designed and implemented to control parasitic infections.
Steroidal saponins from Asparagus dumosus.
A new steroidal saponin, dumoside, characterized as (20S)-3 beta, 16 beta-dihydroxy pregn-5-ene-22-carboxylic acid (22, 16)-lactone-3-O-beta-chacotrioside, was isolated from the whole plant of Asparagus dumosus Baker and the structure was deduced from spectral data. In addition to dumoside three more steroidal saponins characterized as 3 beta-dihydroxy pregn-5,16-dien-20-one 3-O-beta-chacotrioside, 3 beta, 22 alpha, 26-trihydroxyfurost-5-ene-3-O-beta-chacotrioside-26-O- beta-D-glucopyranoside and its corresponding 22 alpha-O methoxy analogue were also isolated for the first time from this source. The structures have been identified with the help of FAB-MS, 1H NMR, 13C NMR and extensive 2D NMR spectroscopy, as well as comparison with reported spectroscopic data.
Chemical constituents of sapindus mukorossi gaertn. (Sapindaceae).
Six new fatty esters of tetracyclic triterpenoid (1-6) together with a known acyclic sesquiterpenoidal glycoside (7) have been isolated from the fruits of Sapindus mukorossi belonging to the family Sapindaceae. Their structures were elucidated with the help of extensive spectroscopic techniques and by chemical means.
Two triterpenoidal saponins from sapindus, mukorossi gaertn.
The two triterpenoidal saponins 2 and 3 containing hederagenin aglycone moiety (1) have been isolated from the butanol soluble fraction of the fruits (without shells) of Sapindus mukorossi Gaertn. Their structures were elucidated with the aid of chemical and spectroscopic means.
Cell cycle and drug sensitivity studies of leukemic cells that appear relevant in determining response to chemotherapy in acute nonlymphocytic leukemia.
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Studies on serum mucoproteins in patients with urinary calculi.
A significant increase in serum mucoproteins in stone patients has been observed previously. The present study describes the variation of the constituents of mucoproteins obtained on hydrolysis. The serum mucoproteins of 31 patients with urinary calculi (13 with kidney stone, 7 with bladder stone and 11 with stones in other sites) were analysed and compared with that of 15 healthy control subjects, who had no personal or family history of calculi. The mucoproteins, glycosylated serum proteins, hexosamine and sialic acid were increased in all patients irrespective of the site of stone, while uronic acid decreased as compared with the control subjects. Serum fucose increased in all patients except in kidney stone formers. Uronic acid decreased in all stone formers irrespective of the site of the stone. It is suggested that a different type of mucoprotein is present in such patients.