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Biomedical subjects

S Peker

Publications and source records attributed to S Peker.

7 recordsLinked to original sources
PubMed1994

Ossified somatotropinoma.

Calcification of pituitary adenomas as a histopathologic finding is reported in up to 25% of all degenerated adenomas. On the other hand, ossification of these adenomas is an extremely rare finding, with only one reported case, a prolactinoma. Here, we report a case of somatotropinoma in a 42-year-old acromegalic female. The adenoma, about 2 cm in diameter, was removed by the transsphenoidal route. Pathologic examination revealed ossification areas in the adenoma and the patient showed dramatic progress with relief of acromegaly signs and normalization of serum growth hormone levels. This case seems to be a unique report of osteoid metaplasia of a somatotropinoma.

Adenoma↗
PubMed1993

Lipid peroxide level increase in experimental hydrocephalus.

The aetiology of incomplete adrenergic denervation and reduction in the number and caliber of the cerebral vessels in hydrocephalus is still obscure. Stretching of the blood vessels alone is far from explaining these major vascular changes. Previous studies have shown that increased lipid peroxidation produces toxic effects on vessels. This experimental study was designed to investigate the possible aetiology of vascular changes in hydrocephalic rats with special reference to lipid peroxidation. Hydrocephalus was induced by injecting 50 mg/Kg sterilized kaolin suspension into the cisterna magna in 10 rats (Group A). A sham operation was performed for Group B. After three weeks the rats were anaesthetized and perfused transcardially. The brains were dissected, and cut to visualize the degree of hydrocephalus. The arteries of the circle of Willis were removed for light microscopic examination and the brains were kept for the measurement of lipid peroxidation levels. Light microscopic studies of cerebral arteries in hydrocephalic rats revealed spastic vessels with folding and corrugation of the lamina elastica. The level of lipid peroxidation in group A (260 +/- 9.129 nmol TBAR/gr wet tissue) was significantly higher than that of group B (106 +/- 3.59 nmol TBAR/gr wet tissue). It is suggested that vascular changes observed in hydrocephalic rats may be due to the high level of lipid peroxidation, which in turn may be the consequence of ischaemia caused by the hydrocephalus related stretching of cerebral vessels.

Animals↗
PubMed1993

Persistent primitive proatlantal intersegmental artery (proatlantal artery I) results in 'top of the basilar' syndrome.

BACKGROUND: Persistent primitive proatlantal intersegmental artery (proatlantal artery I) is an anastomotic channel between the carotid and vertebrobasilar arterial systems. Persistence of this embryonic anastomosis is very rare. The "top of the basilar" syndrome is usually due to occlusion of thalamoperforating arteries by emboli that rise from the vertebrobasilar arterial system. In this case, however, the emboli stemmed from atherosclerotic plaques in the carotid system. CASE DESCRIPTION: A 55-year-old woman was hospitalized with top of the basilar syndrome. A brain scan showed hypodense lesions extending from the mesencephalon to both thalami. Digital subtraction angiography of the cerebral circulation was performed, which revealed a proatlantal artery I on the left side. In addition, atheromatous plaques were seen along the internal and common carotid arteries on the same side. CONCLUSIONS: The occurrence of proatlantal artery I is extremely rare. Top of the basilar syndrome is also rarely encountered. To our knowledge, this is the first report of a patient with both conditions.

Arteries↗
PubMed1991

Effects of hydrocephalus on the sympathetic nerves of cerebral arteries, investigated with WGA-HRP anterograde tracing in the rat.

The effects of hydrocephalus on the plexus of sympathetic nerves of the intracranial vessels were investigated using wheat germ agglutinin combined with horseradish peroxidase (WGA-HRP). Hydrocephalus was induced by injection of kaolin into the cisterna magna of rats. Three weeks later the superior cervical ganglion (SCG) of one side received WGA-HRP. Three days later the circle of Willis and the contralateral superior cervical ganglion were dissected out. The intensity of labelling and density on the cerebral vessels and the number of labelled neurons on the contralateral superior cervical ganglion were calculated. The intensity of labelled nerves and thick bundles were significantly decreased, although tracing the nerve fibers throughout the length of the vessels was possible. The number of labelled neurons in the contralateral superior cervical ganglion indicated that the injection technique of WGA-HRP into the ganglion was correct in all rats. These results are in favour of the assumption, that the hydrocephalus related incomplete adrenergic denervation of the sympathetic perivascular nerve plexus was mainly due to neuropraxia of the nerve fibers rather than anatomical interruption of the axons.

Animals↗
PubMed1990

Multiple thoracic disc herniations.

Multiple thoracic disc herniation is a rare disease. There are only 12 cases reported in the literature. They were treated surgically. Two cases of multiple thoracic disc herniations subjected to laminectomy without discectomy are presented in this report.

Adult↗
PubMed1990

Wrestling causing paraplegia.

This report deals with 4 patients who had a spinal cord injury resulting from wrestling. The cause and the results are discussed.

Adolescent↗