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Biomedical subjects

S Payne

Publications and source records attributed to S Payne.

At least 127 records · Page 7Linked to original sources

Indications for pump-assisted enteral feeding.

Of 80 patients fed enterally over nine months, 10 had serious gastrointestinal complications from gravity-controlled continuous enteral feeding. Use of an infusion pump controlled diarrhoea in patients with gastrointestinal disorders, but was less successful in patients with poor gastric emptying or impaired swallowing reflexes. Thus a pump is not indicated for routine use but, in carefully selected patients, it can obviate the necessity for parenteral nutrition.

Enteral Nutrition↗

The intracellular localisation of immunoglobulin in human lymphoid cells and haematopoietic cell lines by immunoperoxidase electron microscopy.

A technique is described for the ultrastructural localisation of intracellular immunoglobulin (Ig) in human lymphoid cell suspensions by the immunoperoxidase method. The technique involves restricted saponin digestion of glutaraldehyde prefixed cells to enhance conjugate penetration. With this method of staining Ig was located in the rough endoplasmic reticulum, perinuclear space and Golgi apparatus in human lymphoid cells from a variety of sources, which is consistent with previously published observations using other ultrastructural techniques. In contrast, diffuse intracytoplasmic staining was predominant in cells prefixed with glutaraldehyde but not treated with saponin. These differences in patterns are discussed in terms of membrane permeability. Although saponin treatment was necessary for consistent localisation of intracellular Ig it resulted in unavoidable loss of Ig from the surface of the cells.

Bone Marrow↗

A functional assessment of total knee replacement in the arthritic patient.

The aims of knee replacement are to provide freedom from pain and a return to a resonable level of function. A survey was undertaken to determine the functional advantages of knee replacement and problems that may still be encountered by the patient. The results of the survey highlighted certain advantages and problem areas. It also pointed out the seemingly greater functional value of the knee replacement in those patients who had no problems in other joints.

Adult↗

Differences in perception of quality of life issues between health professionals and patients with pancreatic cancer.

During the initial stages of development of a pancreatic cancer quality of life (QoL) module to supplement the EORTC core QoL module, the QLQ-C30, a qualitative study was undertaken to explore observed differences in the health professionals' and patients' perception of the illness, treatment and care of pancreatic cancer. Semi-structured one-to-one interviews were conducted with a range of six health professionals and 21 pancreatic cancer patients from two acute general hospitals and one teaching hospital within the Wessex Region. Grounded theory guided data collection and analysis. There was good agreement between the content of issues generated by professionals and patients with 42 relevant and specific issues identified. However, subtle differences in perception were observed when the context of why such issues were important was examined between the two groups. Health professionals took a mechanistic view and saw the impact of each symptom or problem as directly affecting quality of life perception. Patients' perception of quality of life was mediated by the process of coping. This was grounded by two linked factors. First, the perceived threat of each symptom or problem to the patient and second, the success or otherwise of coping strategies employed to maintain control. Five main coping strategies were identified. This study highlighted that there are important and specific quality of life issues which warrant a need for a pancreatic cancer QoL module. This study emphasises the fact that patients are the best source to describe their quality of life. Health professionals should acknowledge the effect of coping strategies when assessing the impact of symptoms and their treatment on patients with pancreatic cancer.

Adenocarcinoma↗

Ductal carcinoma in situ (DCIS) of the breast: the need for psychosocial research.

Since the introduction of the National Health Service Breast Screening Programme (NHSBSP), the number of ductal carcinoma in situ (DCIS) cases has increased considerably. Despite its increased incidence, some NHS leaflets and reports do not mention it, and the general public seems largely unaware of its existence. There are numerous biological studies dealing with this condition, but its psychosocial aspects seem to have been neglected. We have only been able to locate two British studies (Farmer, A. 1996. Unpublished PhD thesis, University of Southampton; Webb, C. and Koch, T. 1997. J. Adv. Nurs., 25, 154-525) that address some of the psychosocial issues associated with DCIS. This paper starts by defining DCIS and explaining its usual presentation, natural history and epidemiology. The treatment options for DCIS are described, together with the great deal of confusion and lack of agreement that accompanies them. The psychological issues that women with screen-detected DCIS have to deal with are different from those affecting women diagnosed with symptomatic breast cancer, and a summary of these issues is given. Finally, some suggestions for future psychosocial research are provided. Because the UK as a whole was not covered by the NHSBSP until 1990 (Baum, M. 1995. Lancet, 346, 436; Gage and Fouquet, 1997), the main focus will be on papers published from that year onwards, although some key papers published before then will also be included. The papers reviewed here were found in MEDLINE, EMBASE and BIDS (ISI).

Breast Neoplasms↗

Searching for safety signals: the experience of medical surveillance amongst men with testicular teratomas.

The aim of this study is to compare the experience of a group of men with Stage 1 testicular teratomas who were being managed through a surveillance programme (n=25) with a group of patients who had received chemotherapy for more advanced disease (n=22). The study employed a two-phase sequential design that combined quantitative and qualitative methods of data analysis. In the first phase, the hospital anxiety and depression scales (HADS) were used to screen for psychological morbidity. Twelve (48%) of the men assigned to the surveillance programme scored in the 'borderline' or 'clinical case' range on the anxiety subscale of the HADS, compared with six (27%) in the chemotherapy group. There was a significant negative correlation in the surveillance group between 'time since diagnosis' and an elevated anxiety subscale score on the HADS. Interviews were then conducted with 25 participants; a grounded theory approach was used to analyse the transcripts. The hypothesis that human beings are seekers of safety signals provided an explanatory model to account for the higher incidence of self-reported anxiety amongst the men in the surveillance programme.

Adaptation, Psychological↗

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