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Biomedical subjects

S Paul

Publications and source records attributed to S Paul.

At least 325 records · Page 18Linked to original sources
PubMed1976

Ord River arboviruses--isolations from mosquitoes.

One hundred and thirty presumptive viruses have been isolated from 485 pools made from 23,872 mosquitoes collected in the Ord River area of North-West Australia. One hundred and eleven of the virus isolates isolates came from pools of Culex annulirostis, the dominant mosquito species caught in the vicinity of Kununurra. Forty-five of the viruses pathogenic for newborn mice have been further characterized-19 as Flaviviruses, 1 Alphavirus, 9 Koongol, 1 Mapputta and 15 non-haemagglutinating viruses of which 6 are Corripata. Thirty-seven isolates were from Culex annulirostis, 7 from Aedomyia catasticta and 1 from aedes tremulus. All Corriparta isolates were from Aedomyia catasticta. The Flaviviruses comprised 13 Kunjin and 6 MVE isolates.

Animals↗
PubMed1976

Ord River arboviruses--serological epidemiology.

This paper presents the results of haemagglutination-inhibition tests carried out on sera from 441 persons, 1,080 cattle and 335 birds in the Kimberley area. Two Alphaviruses (group A) (Ross River and Sindbis) and one Flavivirus (Murray Valley Encephalitis) were used for the preparation of haemagglutinins in the haemagglutination-inhibition tests. The tests showed a high percentage of antibody of Murray Valley Encephalitis in humans, birds and cattle, with an obvious focus of infection in the study site when cattle sera from different geographic areas were compared. These results are discussed in relation to the evolution and ecology of arboviruses in the Ord River area.

Adult↗
PubMed1976

Suppressor thymus-derived lymphocytes in fungal infection.

Thymus-derived lymphocyte (T-cell) function, as determined in vivo by cutaneous reactivity to several antigens and in vitro by responsiveness to mitogens and antigens, was assessed in 14 patients infected with a variety of fungal organisms. While all patients manifested a normal frequency of peripheral blood T cells, only seven patients reacted to at least one of the antigens used for cutaneous testing and demonstrated normal in vitro T proliferative responses. Three patients exhibited cutaneous anergy but normal in vitro T-cell reactivity while four patients demonstrated persistent anergy and marked in vitro T-cell hyporeactivity which was independent of activity of infection, concurrent medication, or any associated disorders. The marked diminution of in vitro T-cell reactivity noted for these later four patients was not due to a deletion of antigen- or mitogen-reactive cells. Thus, patients' cells which had been initially cultured for 7 days without any mitogenic or antigenic stimulus and which were subsequently washed and recultured with phytohemagglutinin, concanavalin A, or histoplasmin demonstrated a marked increase in their responsiveness. Moreover, this reactivity noted for recultured cells could be suppressed by a nonphagocytic, nonadherent, nonimmunoglobulin-bearing, sheep red blood cell rosette-forming population of cells isolated from the fresh peripheral blood mononuclear cells of the same patient. While these "regulator" T cells were capable of suppressing T-proliferative responses to antigens and mitogens, they did not diminish pokeweed mitogen-induced immunoglobulin synthesis by normal bone marrow-derived lymphocytes. Patients in whom suppressor "T" cells were found were at risk for relapsing, disseminated fungal infection.

Antigen-Antibody Reactions↗
PubMed1971

Retention.

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Dentistry↗