Search PubMed⌕ Search

Biomedical subjects

S Panda

Publications and source records attributed to S Panda.

4 recordsLinked to original sources
PubMed1992

[Inner nuclear layer of the retina in eyes with secondary angle-block glaucoma].

Glaucomatous changes have been known to occur in the inner retinal layer all over the fundus and in the deep retinal layer and retinal pigment epithelium close at the optic disc border. This study was conducted to address the question as to whether the middle retinal layers are altered by the glaucomatous process. The study included histological slides of 23 eyes enucleated due to painful secondary traumatic angle-closure glaucoma and 14 nonglaucomatous eyes removed because of a malignant choroidal melanoma. We evaluated the cell count and thickness of the inner nuclear layer via histomorphometry. The inner nuclear layer contained significantly fewer cells and was thinner (P < 0.05) in the glaucoma group compared to the control group. Since this study contains eyes with possible secondary changes due to the initial trauma, further investigations on eyes with primary open-angle glaucoma are necessary to confirm the results. This could be important for psychophysical testing in glaucoma.

Adult↗
PubMed1992

Decreased photoreceptor count in human eyes with secondary angle-closure glaucoma.

Glaucoma has been known to be associated with a loss of retinal ganglion cells and their axons throughout the fundus and a decreased count of photoreceptors and retinal pigment epithelial (RPE) cells in the parapapillary region. This study investigated whether glaucomatous changes of the deep retinal layer occur outside the parapapillary region. The nuclei of the retinal photoreceptors and RPE cells were counted in histologic slides of 23 eyes with painful secondary angle-closure glaucoma resulting from perforating corneal injuries. Fourteen eyes with malignant choroidal melanoma not involving the ciliary body or trabecular meshwork served as the control group. No surgical procedure, including laser treatment, had been performed posterior to the ora serrata. There were no hints of retinal vessel occlusion and localized traumatic retinopathy, historically, ophthalmoscopically, or histologically. Photoreceptor count was significantly lower (P less than 0.05) in the glaucoma eyes than in the control group. Count of RPE cells did not differ between the two groups. This may indicate that glaucoma can be associated with a loss of photoreceptors. This could be important for psychophysical testing and may point to a more widespread involvement of ocular tissues in glaucoma than believed.

Adult↗
PubMed1990

Effect of magnesium and calcium ions on photoinduced lipid peroxidation and thylakoid breakdown of cell-free chloroplasts.

Aging of cell-free chloroplasts at pH 7.0 and 9.0 causes a decline in the level of photosynthetic pigments, quenching of chlorophyll a fluorescence and enhancement in fluorescence polarization. These changes are correlated with photoinduced enhancement of thylakoid lipid peroxidation. The alkaline earth metal cations, namely magnesium and calcium, show opposite actions on lipid peroxidation and modulate thylakoid disorganisation differently. Magnesium ion may stabilise thylakoid membrane by retarding lipid peroxidation. It lowers aging-induced quenching of fluorescence intensity and enhancement of fluorescence polarization. Calcium ion, on the other hand, stimulates disorganisation of thylakoid membranes. It enhances membrane lipid peroxidation, quenching of chlorophyll a fluorescence intensity and fluorescence polarization.

Calcium↗