[A benign adrenal schwannoma].
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Adrenal Gland Neoplasms↗
Biomedical subjects
S Palacios Llopis
Publications and source records attributed to S Palacios Llopis.
Histogenesis of malignant melanoma of the skin: the role of lymphocytes in the transformation of tissue developmental units.
It is proposed that the completion of both growth and differentiation, in highly specialized progressively evolving multicellular organisms, is achieved throughout two separated but sexually interacting populations of cells (bi-clonal model): 1) the germ line, seated in an obligatory axial position, required for the generation of cytoplasmic replicons, is the source of travelling vectors (spermatozoa, lymphocytes ...) endowed with these potentially transforming nucleoproteins. 2) The centrifugally growing somatic tissues subjected to mitotic senescence. The progressive loss of replicons probably triggers meiotic-like recombinations and differentiation in distal tissues. The shedding of axial replicons to distal meiotic targets seems to be instrumental in transformation, initiating both, embryogenesis and cancer. This theoretical approach is applied to the histogenetic model of malignant melanoma of the skin. In this setting, the axial population is identified as lymphocytes involved in a process of extrathymic maturation (lichenoid lesions), in the same field where melanoma would arise. Pagetoid nests of melanocytes are considered to be the expression of TDUs evolving in a distal population of senescent neurocristic cells. This situation establishes the likelihood of mixing between potentially transforming lymphocytes and the meiotic melanocytes resulting in a transformed hybrid, the earliest cellular expression of malignant melanoma.
Cell Differentiation↗
Is a bi-clonal interaction, analogous to that underlying embryogenesis the origin of the earliest malignant phenotype?
We propose a theoretical model of carcinogenesis which parallels embryonic induction. It is based on the interaction between two clones of cells. One of them is of germ cell ancestry and is the source of transforming effector cells. The second clone is the potential target of such travelling "lymphocytoid" cells and emerges in tissues exhibiting the precancerous picture of dysplasia. In atypical fields each endopolyploid cell, arrested in G2 and involved in genomic changes, is the stem of a clonal growth. This emerging new phenotype is subjected to policing control by wandering effector cells. This situation establishes the probability of a random collision between two cells pertaining to different lineages, with two possible antithetical results, cytolysis or cell fusion comparable to fertilization. The latter event is suggested to determine malignancy.
Animals↗
[Based on the incidence of Creutzfeldt-Jakob disease in the Lanzarote healthcare area. Description of two definitive cases].
We present two cases who have been diagnosed of definitive Creutzfeldt-Jakob disease in the health area of Lanzarote in the period January 2002 to January 2004. The two cases are presented with clinical description, complementary tests -- including electroencephalogram, 14-3-3 protein determination -- study of the prionic protein gene, and histopathologic findings. In this article, we try to show the importance of trying to reach a definitive diagnosis with the histopathologic study once there is clinical suspicion (a diagnosis that is probable or possible). In addition our cases show that communication between the clinical and the epidemiological coordinator of the regional community and the National Center of Epidemiology is very important. We refer to the clear growth in the incidence of the disease in the population of Lanzarote in the period above mentioned. Finally, we discuss whether this growth is or is not an isolated event.
Aged↗