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Biomedical subjects

S P Master

Publications and source records attributed to S P Master.

10 recordsLinked to original sources
PubMed1994

Parental origin of chromosome 9q22.3-q31 lost in basal cell carcinomas from basal cell nevus syndrome patients.

The basal cell nevus syndrome is an autosomal dominant disease, one of the most prominent phenotypic features of which is a large number of cutaneous basal cell carcinomas. The gene whose mutation underlies this disease has been mapped to chromosome 9q22.3-q31, and basal cell carcinomas frequently have allelic losses including this site. We report here that the chromosome 9q22.3-q31 lost in 24 basal cell carcinomas from basal cell nevus syndrome patients was the one predicted by linkage to contain the wild-type gene. Hence these data are compatible with the exception that the product of the basal cell nevus syndrome gene acts as a tumor suppressor.

Alleles↗
PubMed1991

Peripheral vision screening for driving in retinitis pigmentosa patients.

The authors evaluated the test protocols used most frequently to screen the peripheral visual field of driving applicants to determine whether they are suitable for detecting peripheral field loss in patients with retinitis pigmentosa (RP). The peripheral vision tests available on the Keystone View Tester and the Titmus Vision Tester were administered to 23 subjects with RP, 3 subjects with Type 2 Usher's syndrome, and 1 subject who was a partially affected carrier of X-linked recessive RP. The subjects had varying degrees and types of visual field loss. Tests were administered using the standard protocol of the State of Illinois, which is a standard procedure used by state licensing bureaus nationwide. Results demonstrate that the screening protocols use stimulus conditions that are primarily sensitive only to appreciable field losses and examine locations that typically lie within an RP patient's remaining visual field rather than at locations that characteristically are scotomatous. The authors suggest that the current test protocols could determine peripheral field impairment more accurately by assessing additional locations in the visual field, and by introducing a background field and/or by reducing the luminance of the test targets.

Adult↗
PubMed1975

Pancreatic pseudocysts in children: 4 cases from Uganda.

Four cases of pancreatic pseudocyst in African children are described. There is some evidence that they followed pancreatitis of unknown aetiology. None had a history of trauma. Three were treated by cystogastrostomy, and the fourth by excision of the cyst.

Body Weight↗
PubMed1970

Immunological studies in Kaposi's sarcoma in Uganda.

An evaluation of humoral and cellular immune mechanisms was performed on patients with Kaposi's sarcoma in Uganda. Antibody responses and immunoglobulin levels were normal in all patients studied. Nevertheless, a striking impairment in the delayed hypersensitivity response to dinitrochlorobenzene was noted in patients with the "malignant" type of tumour.

Antibodies↗
PubMed1970

Kaposi sarcoma of lymph nodes.

Sixteen out of 48 adult African patients with Kaposi sarcoma were found to have tumour tissue in lymph nodes. The evidence suggests that there are probably two main types of involvement. One occurs predominantly in younger patients and involves many groups of glands, probably develops in situ, and is associated with a poor prognosis. The other form is the result of metastasis to a node from an aggressive tumour in the neighbourhood. This occurs more commonly in the older patient and carries a much better prognosis than in those with generalised lymphadenopathy, though worse than in patients with nodular disease without gland involvement. Follow-up over a period of many years will be required to discover the outcome in these cases. Kaposi sarcoma is unusual in women but when it occurs runs a more aggressive course than in men.

Adolescent↗